PMID- 34687238 OWN - NLM STAT- MEDLINE DCOM- 20220323 LR - 20220731 IS - 1475-1313 (Electronic) IS - 0275-5408 (Print) IS - 0275-5408 (Linking) VI - 42 IP - 1 DP - 2022 Jan TI - Retinal defocus in myopes wearing dual-focus zonal contact lenses. PG - 8-18 LID - 10.1111/opo.12903 [doi] AB - PURPOSE: To evaluate the refractive impact of dual-focus (DF) myopia control contact lenses (CLs) on accommodating young myopic adults. METHODS: Phase 1: accommodative accuracy was assessed in 40 myopic participants. Phase 2: a subset of four subjects who demonstrated accurate accommodation and six who chronically underaccommodated were fitted with single vision (SV, Proclear 1 day) and centre-distance DF myopia control CLs (MiSight 1 day) with approximately +2.00 D of additional power in two surrounding annular zones. While binocularly viewing high contrast characters at 4.00, 1.00, 0.50, 0.33, 0.25 and 0.20 m, aberrometry data were captured across the central +/-30 degrees of the horizontal retina. Local refractive errors were pooled for each area of the pupil covered by the central distance or first annular defocus zone of the DF CLs. RESULTS: In the "good" accommodator group fitted with SV CLs, accommodative lags were generally absent except at the closest viewing distance (mean errors: -0.09 +/- 0.22 D, -0.12 +/- 0.26 D, -0.05 +/- 0.37 D and +0.38 +/- 0.54 D for -2.00, -3.00, -4.00 and -5.00 D target vergences, respectively) but significantly larger in the "poor" accommodating participants (+0.81 +/- 0.21 D, +0.97 +/- 0.27 D, +1.18 +/- 0.39 D, +1.47 +/- 0.55 D). For most viewing distances, hyperopic defocus observed in the region of the pupil covered by the first annular zone was replaced with myopic defocus when fitted with the DF CLs. Myopic defocus created by the first annular region was present across the central 30 degrees of the retina. CONCLUSIONS: Some young adult myopes chronically experience high levels of hyperopic defocus when viewing near targets, which was replaced by myopic defocus in the annular part of the pupil covered by the treatment zones when fitted with a centre-distance myopia control DF CL. CI - (c) 2021 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists. FAU - Singh, Neeraj K AU - Singh NK AUID- ORCID: 0000-0003-3424-3492 AD - School of Optometry, Indiana University, Bloomington, Indiana, USA. FAU - Meyer, Dawn AU - Meyer D AUID- ORCID: 0000-0002-5157-2557 AD - School of Optometry, Indiana University, Bloomington, Indiana, USA. FAU - Jaskulski, Matt AU - Jaskulski M AUID- ORCID: 0000-0001-5824-7135 AD - School of Optometry, Indiana University, Bloomington, Indiana, USA. FAU - Kollbaum, Pete AU - Kollbaum P AUID- ORCID: 0000-0001-9568-2064 AD - School of Optometry, Indiana University, Bloomington, Indiana, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20211023 PL - England TA - Ophthalmic Physiol Opt JT - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JID - 8208839 SB - IM MH - Accommodation, Ocular MH - *Contact Lenses MH - Humans MH - *Myopia/therapy MH - Refraction, Ocular MH - Retina MH - Young Adult PMC - PMC9298321 OTO - NOTNLM OT - accommodation OT - contact lenses OT - dual-focus OT - myopia OT - optical aberrations OT - peripheral refraction OT - retinal defocus COIS- None. EDAT- 2021/10/24 06:00 MHDA- 2022/03/24 06:00 PMCR- 2022/07/20 CRDT- 2021/10/23 08:36 PHST- 2021/09/13 00:00 [revised] PHST- 2021/08/12 00:00 [received] PHST- 2021/09/14 00:00 [accepted] PHST- 2021/10/24 06:00 [pubmed] PHST- 2022/03/24 06:00 [medline] PHST- 2021/10/23 08:36 [entrez] PHST- 2022/07/20 00:00 [pmc-release] AID - OPO12903 [pii] AID - 10.1111/opo.12903 [doi] PST - ppublish SO - Ophthalmic Physiol Opt. 2022 Jan;42(1):8-18. doi: 10.1111/opo.12903. Epub 2021 Oct 23.