PMID- 34687351
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20240422
IS  - 1432-0738 (Electronic)
IS  - 0340-5761 (Print)
IS  - 0340-5761 (Linking)
VI  - 96
IP  - 1
DP  - 2022 Jan
TI  - Persistent autism-relevant behavioral phenotype and social neuropeptide 
      alterations in female mice offspring induced by maternal transfer of PBDE 
      congeners in the commercial mixture DE-71.
PG  - 335-365
LID - 10.1007/s00204-021-03163-4 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent organic 
      pollutants (POPs) that are known neuroendocrine disrupting chemicals with adverse 
      neurodevelopmental effects. PBDEs may act as risk factors for autism spectrum 
      disorders (ASD), characterized by abnormal psychosocial functioning, although 
      direct evidence is currently lacking. Using a translational exposure model, we 
      tested the hypothesis that maternal transfer of a commercial mixture of PBDEs, 
      DE-71, produces ASD-relevant behavioral and neurochemical deficits in female 
      offspring. C57Bl6/N mouse dams (F0) were exposed to DE-71 via oral administration 
      of 0 (VEH/CON), 0.1 (L-DE-71) or 0.4 (H-DE-71) mg/kg bw/d from 3 wk prior to 
      gestation through end of lactation. Mass spectrometry analysis indicated in utero 
      and lactational transfer of PBDEs (in ppb) to F1 female offspring brain tissue at 
      postnatal day (PND) 15 which was reduced by PND 110. Neurobehavioral testing of 
      social novelty preference (SNP) and social recognition memory (SRM) revealed that 
      adult L-DE-71 F1 offspring display deficient short- and long-term SRM, in the 
      absence of reduced sociability, and increased repetitive behavior. These effects 
      were concomitant with reduced olfactory discrimination of social odors. 
      Additionally, L-DE-71 exposure also altered short-term novel object recognition 
      memory but not anxiety or depressive-like behavior. Moreover, F1 L-DE-71 
      displayed downregulated mRNA transcripts for oxytocin (Oxt) in the bed nucleus of 
      the stria terminalis (BNST) and supraoptic nucleus, and vasopressin (Avp) in the 
      BNST and upregulated Avp1ar in BNST, and Oxtr in the paraventricular nucleus. Our 
      work demonstrates that developmental PBDE exposure produces ASD-relevant 
      neurochemical, olfactory processing and behavioral phenotypes that may result 
      from early neurodevelopmental reprogramming within central social and memory 
      networks.
CI  - (c) 2021. The Author(s).
FAU - Kozlova, Elena V
AU  - Kozlova EV
AUID- ORCID: 0000-0002-4691-6618
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
AD  - Neuroscience Graduate Program, University of California, Riverside, CA, 92521, 
      USA.
FAU - Valdez, Matthew C
AU  - Valdez MC
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
AD  - Neuroscience Graduate Program, University of California, Riverside, CA, 92521, 
      USA.
AD  - Neurological and Endocrine Toxicology Branch, Public Health and Integrated 
      Toxicology Division, CPHEA/ORD, U.S. Environmental Protection Agency, Research 
      Triangle Park, Durham, NC, 27711, USA.
FAU - Denys, Maximillian E
AU  - Denys ME
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Bishay, Anthony E
AU  - Bishay AE
AUID- ORCID: 0000-0002-6057-3770
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Krum, Julia M
AU  - Krum JM
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Rabbani, Kayhon M
AU  - Rabbani KM
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Carrillo, Valeria
AU  - Carrillo V
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Gonzalez, Gwendolyn M
AU  - Gonzalez GM
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Lampel, Gregory
AU  - Lampel G
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Tran, Jasmin D
AU  - Tran JD
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Vazquez, Brigitte M
AU  - Vazquez BM
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Anchondo, Laura M
AU  - Anchondo LM
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Uddin, Syed A
AU  - Uddin SA
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Huffman, Nicole M
AU  - Huffman NM
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Monarrez, Eduardo
AU  - Monarrez E
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Olomi, Duraan S
AU  - Olomi DS
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Chinthirla, Bhuvaneswari D
AU  - Chinthirla BD
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA.
FAU - Hartman, Richard E
AU  - Hartman RE
AD  - Department of Psychology, Loma Linda University, Loma Linda, CA, 92350, USA.
FAU - Kodavanti, Prasada Rao S
AU  - Kodavanti PRS
AD  - Neurological and Endocrine Toxicology Branch, Public Health and Integrated 
      Toxicology Division, CPHEA/ORD, U.S. Environmental Protection Agency, Research 
      Triangle Park, Durham, NC, 27711, USA.
FAU - Chompre, Gladys
AU  - Chompre G
AD  - Biotechnology Department, Pontifical Catholic University of Puerto Rico, Ponce, 
      Puerto Rico, 00717-9997, USA.
FAU - Phillips, Allison L
AU  - Phillips AL
AD  - Duke University, Nicholas School of the Environment, Durham, NC, 27710, USA.
FAU - Stapleton, Heather M
AU  - Stapleton HM
AD  - Duke University, Nicholas School of the Environment, Durham, NC, 27710, USA.
FAU - Henkelmann, Bernhard
AU  - Henkelmann B
AD  - Helmholtz Zentrum Munchen, Molecular EXposomics (MEX), German National Research 
      Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, Neuherberg, 
      Munich, Germany.
FAU - Schramm, Karl-Werner
AU  - Schramm KW
AUID- ORCID: 0000-0002-8945-4062
AD  - Helmholtz Zentrum Munchen, Molecular EXposomics (MEX), German National Research 
      Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, Neuherberg, 
      Munich, Germany.
AD  - Department Fur Biowissenschaftliche Grundlagen, TUM, Wissenschaftszentrum 
      Weihenstephan fur Ernahrung, Landnutzung Und Umwelt, Weihenstephaner Steig 23, 
      85350, Freising, Germany.
FAU - Curras-Collazo, Margarita C
AU  - Curras-Collazo MC
AUID- ORCID: 0000-0002-0189-4179
AD  - Department of Molecular, Cell and Systems Biology, University of California, 
      Riverside, CA, 92521, USA. mcur@ucr.edu.
LA  - eng
GR  - T34 GM062756/GM/NIGMS NIH HHS/United States
GR  - T34GM062756/NH/NIH HHS/United States
GR  - NIH R01 ES016099/NH/NIH HHS/United States
GR  - G12 MD007579/MD/NIMHD NIH HHS/United States
GR  - G12 RR003050/RR/NCRR NIH HHS/United States
GR  - R01 ES016099/ES/NIEHS NIH HHS/United States
GR  - U54 MD007579/MD/NIMHD NIH HHS/United States
PT  - Journal Article
DEP - 20211023
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Neuropeptides)
RN  - 7REL09ZX35 (pentabromodiphenyl ether)
SB  - IM
MH  - Animals
MH  - *Autistic Disorder
MH  - Female
MH  - *Flame Retardants
MH  - Halogenated Diphenyl Ethers/toxicity
MH  - Humans
MH  - Maternal Exposure/adverse effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Neuropeptides
MH  - Phenotype
PMC - PMC8536480
OTO - NOTNLM
OT  - Developmental exposure
OT  - Endocrine-disrupting chemicals
OT  - Flame retardants
OT  - Oxytocin
OT  - Polybrominated diphenyl ethers
OT  - Vasopressin
COIS- The authors report no conflicts of interests and have no competing interests to 
      declare.
EDAT- 2021/10/24 06:00
MHDA- 2022/04/05 06:00
PMCR- 2021/10/23
CRDT- 2021/10/23 12:07
PHST- 2021/06/11 00:00 [received]
PHST- 2021/09/16 00:00 [accepted]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/10/23 12:07 [entrez]
PHST- 2021/10/23 00:00 [pmc-release]
AID - 10.1007/s00204-021-03163-4 [pii]
AID - 3163 [pii]
AID - 10.1007/s00204-021-03163-4 [doi]
PST - ppublish
SO  - Arch Toxicol. 2022 Jan;96(1):335-365. doi: 10.1007/s00204-021-03163-4. Epub 2021 
      Oct 23.