PMID- 34688280
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 20
IP  - 1
DP  - 2021 Oct 23
TI  - Association of left ventricular longitudinal myocardial function with subclinical 
      right ventricular dysfunction in type 2 diabetes mellitus.
PG  - 212
LID - 10.1186/s12933-021-01404-5 [doi]
LID - 212
AB  - BACKGROUND: Left ventricular (LV) involvement in diabetic cardiomyopathy has been 
      reported; however, only limited data exist on right ventricular (RV) involvement. 
      Therefore, our purpose was to investigate RV systolic dysfunction and its 
      association with LV longitudinal myocardial dysfunction in patients with type 2 
      diabetes mellitus (T2DM) and preserved LV ejection fraction (LVEF). METHODS: We 
      studied 177 T2DM patients with preserved LVEF and 79 age-, sex-, and LVEF-matched 
      healthy volunteers. LV longitudinal myocardial function was assessed as global 
      longitudinal strain (GLS), and RV systolic function was assessed as RV free-wall 
      strain, and predefined cutoff values for subclinical dysfunction were set at GLS 
      < 18% and RV free-wall strain < 20%, respectively. RESULTS: RV free-wall strain 
      in T2DM patients was significantly lower than that in normal controls 
      (19.3% +/- 4.8% vs. 24.4% +/- 5.1%; P < 0.0001). RV free-wall strain in T2DM patients 
      and LV longitudinal dysfunction was similar compared to that in T2DM patients 
      without (19.0 +/- 4.5% vs. 19.6 +/- 5.0%, P = 0.40). Furthermore, multivariate 
      logistic regression analyses showed that GLS was independently associated with RV 
      systolic dysfunction as well as mitral inflow E and mitral e' annular velocities 
      ratio (odds ratio, 1.16; 95% confidence interval: 1.03-1.31; P < 0.05). 
      Sequential logistic models evaluating the association of RV systolic dysfunction 
      in T2DM patients showed an improvement in clinical variables (chi(2) = 6.2) with 
      the addition of conventional echocardiographic parameters (chi(2) = 13.4, 
      P < 0.001) and a further improvement with the addition of GLS (chi(2) = 20.8, 
      P < 0.001). CONCLUSION: RV subclinical systolic dysfunction was observed in T2DM 
      patients with preserved LVEF and was associated with LV longitudinal myocardial 
      dysfunction. Our findings may provide additional findings for the management of 
      T2DM patients.
CI  - (c) 2021. The Author(s).
FAU - Todo, Saki
AU  - Todo S
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Tanaka, Hidekazu
AU  - Tanaka H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan. tanakah@med.kobe-u.ac.jp.
FAU - Yamauchi, Yuki
AU  - Yamauchi Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Yokota, Shun
AU  - Yokota S
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Mochizuki, Yasuhide
AU  - Mochizuki Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Shiraki, Hiroaki
AU  - Shiraki H
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Yamashita, Kentaro
AU  - Yamashita K
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Shono, Ayu
AU  - Shono A
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Suzuki, Makiko
AU  - Suzuki M
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Sumimoto, Keiko
AU  - Sumimoto K
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Tanaka, Yusuke
AU  - Tanaka Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
FAU - Hirota, Yushi
AU  - Hirota Y
AD  - Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Ogawa, Wataru
AU  - Ogawa W
AD  - Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe, Japan.
FAU - Hirata, Ken-Ichi
AU  - Hirata KI
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 
      650-0017, Japan.
LA  - eng
PT  - Journal Article
DEP - 20211023
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Aged
MH  - Asymptomatic Diseases
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis
MH  - Diabetic Cardiomyopathies/diagnostic imaging/*etiology/physiopathology
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*etiology/physiopathology
MH  - Ventricular Dysfunction, Right/diagnostic imaging/*etiology/physiopathology
MH  - *Ventricular Function, Left
MH  - *Ventricular Function, Right
PMC - PMC8542339
OTO - NOTNLM
OT  - Echocardiography
OT  - Global longitudinal strain
OT  - Right ventricular systolic function
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2021/10/25 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/10/23
CRDT- 2021/10/24 20:21
PHST- 2021/08/17 00:00 [received]
PHST- 2021/10/15 00:00 [accepted]
PHST- 2021/10/24 20:21 [entrez]
PHST- 2021/10/25 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/10/23 00:00 [pmc-release]
AID - 10.1186/s12933-021-01404-5 [pii]
AID - 1404 [pii]
AID - 10.1186/s12933-021-01404-5 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2021 Oct 23;20(1):212. doi: 10.1186/s12933-021-01404-5.