PMID- 34688769
OWN - NLM
STAT- MEDLINE
DCOM- 20220202
LR  - 20220202
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 159
DP  - 2022 Jan
TI  - Thalamocortical Dysconnectivity In Lifelong Premature Ejaculation: A Functional 
      MRI Study.
PG  - 133-138
LID - S0090-4295(21)00983-3 [pii]
LID - 10.1016/j.urology.2021.10.010 [doi]
AB  - OBJECTIVES: To detect seed-based functional connectivity (FC) between various 
      cortical sub-regions and the thalamus in lifelong premature ejaculation (LPE) 
      patients and explore whether specific thalamocortical networks are significantly 
      altered in PE patients compared to healthy controls (HCs) METHODS: Fifty 
      non-medicated LPE patients and 40 age-matched HCs underwent a resting-state 
      functional MRI. FC was adopted to identify specific thalamocortical connectivity 
      between the thalamus and 6 cortical regions of interest (i.e., the motor 
      cortex/supplementary motor, the prefrontal cortex, the temporal lobe, the 
      posterior parietal cortex, the somatosensory cortex and the occipital lobe). In 
      LPE patients, regression analysis was subsequently conducted to assess 
      relationships of thalamocortical connectivity with the Premature Ejaculation 
      Diagnostic Tool (PEDT) score and the Intravaginal Ejaculatory Latency Time 
      (IELT). RESULTS: LPE patients had significantly decreased FC between the motor 
      cortex and bilateral ventral thalamus, between the prefrontal cortex and left 
      dorsomedial thalamus, as well as between the temporal cortex and bilateral 
      ventromedial thalamus. In LPE patients, PEDT score was significantly positively 
      associated with the thalamus-posterior parietal cortex FC, and negatively 
      associated with the thalamus-temporal cortex FC, while IELT was positively 
      associated with the thalamus-temporal cortex and thalamus-motor cortex FC. 
      CONCLUSION: These results enrich the imaging evidence for the understanding of 
      the neurobiological mechanisms and/or consequences of LPE.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Gao, Ming
AU  - Gao M
AD  - Department of Urology, Xi'An DaXing Hospital of Shaanxi University of Chinese 
      Medicine, Xi'an, China; Department of Andrology, XiYuan Hospital, China Academy 
      of Chinese Medical Sciences, Beijing, China.
FAU - Geng, Bowen
AU  - Geng B
AD  - Life Science Research Center, School of Life Science and Technology, Xidian 
      University, Xi'an, Shaanxi, China; Engineering Research Center of Molecular and 
      Neuro Imaging Ministry of Education, School of Life Science and Technology, 
      Xidian University, Xi'an, Shaanxi, China.
FAU - Jannini, Tommaso B
AU  - Jannini TB
AD  - School of Psychiatry, Department of Systems Medicine, University of Rome Tor 
      Vergata, Via Montpellier, Roma, Italy.
FAU - Wu, Jiayu
AU  - Wu J
AD  - Life Science Research Center, School of Life Science and Technology, Xidian 
      University, Xi'an, Shaanxi, China; Engineering Research Center of Molecular and 
      Neuro Imaging Ministry of Education, School of Life Science and Technology, 
      Xidian University, Xi'an, Shaanxi, China.
FAU - Wang, Yanzhu
AU  - Wang Y
AD  - Department of Urology, Xi'An DaXing Hospital of Shaanxi University of Chinese 
      Medicine, Xi'an, China.
FAU - Zhang, Yuntao
AU  - Zhang Y
AD  - Department of Urology, Xi'An DaXing Hospital of Shaanxi University of Chinese 
      Medicine, Xi'an, China.
FAU - Yuan, Jianlin
AU  - Yuan J
AD  - Department of Urology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Jannini, Emmanuele A
AU  - Jannini EA
AD  - Chair of Endocrinology and Medical Sexology, Department of Systems Medicine, 
      University of Rome Tor Vergata, Rome, Italy. Electronic address: 
      eajannini@gmail.com.
FAU - Liu, Peng
AU  - Liu P
AD  - Life Science Research Center, School of Life Science and Technology, Xidian 
      University, Xi'an, Shaanxi, China; Engineering Research Center of Molecular and 
      Neuro Imaging Ministry of Education, School of Life Science and Technology, 
      Xidian University, Xi'an, Shaanxi, China. Electronic address: 
      liupengphd@gmail.com.
FAU - Yin, Chuanmin
AU  - Yin C
AD  - Department of Urology, Xi'An DaXing Hospital of Shaanxi University of Chinese 
      Medicine, Xi'an, China. Electronic address: yiniceapple@163.com.
LA  - eng
PT  - Journal Article
DEP - 20211022
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
SB  - IM
MH  - Adult
MH  - *Cerebral Cortex/diagnostic imaging/physiopathology
MH  - Connectome/*methods
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - *Nerve Net/pathology/physiopathology
MH  - Neurophysiology
MH  - *Premature Ejaculation/diagnosis/physiopathology
MH  - *Thalamus/diagnostic imaging/physiopathology
EDAT- 2021/10/25 06:00
MHDA- 2022/02/03 06:00
CRDT- 2021/10/24 20:34
PHST- 2021/09/02 00:00 [received]
PHST- 2021/10/10 00:00 [revised]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/25 06:00 [pubmed]
PHST- 2022/02/03 06:00 [medline]
PHST- 2021/10/24 20:34 [entrez]
AID - S0090-4295(21)00983-3 [pii]
AID - 10.1016/j.urology.2021.10.010 [doi]
PST - ppublish
SO  - Urology. 2022 Jan;159:133-138. doi: 10.1016/j.urology.2021.10.010. Epub 2021 Oct 
      22.