PMID- 34689534
OWN - NLM
STAT- MEDLINE
DCOM- 20211026
LR  - 20211026
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 101
IP  - 39
DP  - 2021 Oct 26
TI  - [Resting-state functional magnetic resonance imaging analysis of modified 
      electroconvulsive therapy in the treatment of major depressive disorder].
PG  - 3221-3226
LID - 10.3780/cma.j.cn112137-20210402-00807 [doi]
AB  - Objective: To explore the effect of modified electroconvulsive therapy (MECT) on 
      resting-state functional connectivity (RSFC) in patients with major depressive 
      disorder (MDD). Methods: Patients with MDD from Anhui Mental Health Center from 
      October 2017 to May 2019 were included. Using bilateral nucleus accumbens (NAcc) 
      as seed points, changes of RSFC were investigated before and after MECT through 
      resting-state functional magnetic imaging (fMRI). Antidepressant effects were 
      measured by 17 items of Hamilton Depressive Rating Scale (HDRS-17). Correlation 
      analysis was performed between changed HRSD-17 scores and changes of functional 
      connectivity. Results: A total of 40 MDD patients (10 males and 30 females), aged 
      (38+/-11) years, who received MECT were included in the study. After MECT, patients 
      showed increased RSFC in the right NAcc (rNAcc) and superior frontal gyrus 
      (P<0.001), right supramarginal gyrus (P<0.001), right angular gyrus (rAG) (P= 
      0.017), right inferior parietal lobule (P= 0.017), left superior frontal gyrus 
      (LSFG) (P<0.001), left middle temporal gyrus (P=0.017) and left angular gyrus 
      (LAG) (P=0.012), respectively. The RSFC changes of rNAcc-LSFG (r=-0.454, P = 
      0.003), rNAcc-rAG (r=-0.437, P=0.005) and rNAcc-lAG (r=-0.383, P=0.015) were 
      negatively correlated with the changes of HRSD-17 scores. Conclusions: MECT may 
      alleviate major depression by regulating the functional connectivity between the 
      rNAcc and bilateral angular gyrus and left superior frontal gyrus.
FAU - Hou, Q Q
AU  - Hou QQ
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, China.
FAU - Wu, Y
AU  - Wu Y
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, China.
FAU - Lyu, H M
AU  - Lyu HM
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, China.
FAU - Zhang, T
AU  - Zhang T
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, China.
FAU - Xie, W
AU  - Xie W
AD  - Department of Neurosis, Anhui Mental Health Center, Hefei 230022, China.
FAU - Bai, T J
AU  - Bai TJ
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, China.
FAU - Tian, Y H
AU  - Tian YH
AD  - Department of Neurology, the First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, China.
LA  - chi
GR  - 32071054/National Natural Science Foundation of China/
GR  - 1808085J23/Outstanding Youth Fund of Anhui Natural Science Foundation/
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Depressive Disorder, Major/diagnostic imaging/therapy
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prefrontal Cortex
MH  - Temporal Lobe
EDAT- 2021/10/26 06:00
MHDA- 2021/10/27 06:00
CRDT- 2021/10/25 02:23
PHST- 2021/10/25 02:23 [entrez]
PHST- 2021/10/26 06:00 [pubmed]
PHST- 2021/10/27 06:00 [medline]
AID - 10.3780/cma.j.cn112137-20210402-00807 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2021 Oct 26;101(39):3221-3226. doi: 
      10.3780/cma.j.cn112137-20210402-00807.