PMID- 34690084 OWN - NLM STAT- MEDLINE DCOM- 20211116 LR - 20220323 IS - 1553-4669 (Electronic) IS - 1553-4650 (Linking) VI - 28 IP - 11 DP - 2021 Nov TI - An International Terminology for Endometriosis, 2021. PG - 1849-1859 LID - S1553-4650(21)01171-7 [pii] LID - 10.1016/j.jmig.2021.08.032 [doi] AB - OBJECTIVE: Different classification systems have been developed for endometriosis, using different definitions for the disease, the different subtypes, symptoms and treatments. In addition, an International Glossary on Infertility and Fertility Care has been published in 2017 by the International Committee for Monitoring Assisted Reproductive Technologies (ICMART) in collaboration with other organisations. An international working group convened over the development of a classification or descriptive system for endometriosis. As a basis for such system, a terminology for endometriosis was considered a condition sine qua non. The aim of the current study was to develop a set of terms and definitions be prepared on endometriosis that would be the basis for standardization in disease description, classification and research. DATA SOURCES: The working group listed a number of terms relevant to be included in the terminology, documented currently used and published definitions, and discussed and adapted them until consensus was reached within the working group. Following stakeholder review, further terms were added, and definitions further clarified. Although definitions were collected through published literature, the final set of terms and definitions is to be considered consensus-based. After finalization of the first draft, the members of the international societies and other stakeholders were consulted for feedback and comments, which lead to further adaptations. METHODS OF STUDY SELECTION: na TABULATION, INTEGRATION, AND RESULTS: A list of 49 terms and definitions in the field of endometriosis is presented, including a definition for endometriosis and its subtypes, different locations, interventions, symptoms and outcomes. Endometriosis is defined as a disease characterized by the presence of endometrium-like epithelium and/or stroma outside the endometrium and myometrium, usually with an associated inflammatory process. CONCLUSION: The current paper outlines a list of 49 terms and definitions in the field of endometriosis. The application of the defined terms aims to facilitate harmonization in endometriosis research and clinical practice. Future research may require further refinement of the presented definitions. CI - Copyright (c) 2021 AAGL. All rights reserved. CN - International working group of AAGL, ESGE, ESHRE and WES FAU - Tomassetti, Carla AU - Tomassetti C AD - University Hospital Leuven, Department of Obstetrics and Gynaecology, Leuven University Fertility Centre (Dr. Tomassetti), Leuven, Belgium. FAU - Johnson, Neil P AU - Johnson NP AD - Robinson Research Institute, University of Adelaide (Dr. Johnson), Adelaide, South Australia. FAU - Petrozza, John AU - Petrozza J AD - Massachusetts General Hospital Fertility Center, Department of Obstetrics and Gynecology (Dr. Petrozza), Boston, Massachusetts. FAU - Abrao, Mauricio S AU - Abrao MS AD - Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo (Dr. Abrao), Sao Paulo, SP, Brazil; Gynecologic Division, BP - A Beneficencia Portuguesa de Sao Paulo (Dr. Abrao), Sao Paulo, SP, Brazil. FAU - Einarsson, Jon I AU - Einarsson JI AD - Brigham and Women's Hospital, Department of Obstetrics and Gynecology, Division of Minimally Invasive Gynecologic Surgery (Dr. Einarsson), Boston, Massachusetts. FAU - Horne, Andrew W AU - Horne AW AD - University of Edinburgh, MRC Centre for Reproductive Health, QMRI, 49 Little France Crescent (Dr. Horne), Edinburgh EH16 4TJ, United Kingdom. FAU - Lee, Ted T M AU - Lee TTM AD - Magee Womens Hospital of UPMC, Department of Obstetrics, Gynecology and Reproductive Sciences (Dr. Lee), Pittsburgh, Pennsylvania. FAU - Missmer, Stacey AU - Missmer S AD - Michigan State University College of Human Medicine, Department of Obstetrics, Gynecology and Reproductive Biology (Dr. Missmer), East Lansing, Michigan; Harvard University T H Chan School of Public Health, Department of Epidemiology (Dr. Missmer), Boston, Massachusetts; World Endometriosis Research Foundation (Dr. Missmer), WERF, London, United Kingdom. FAU - Vermeulen, Nathalie AU - Vermeulen N AD - ESHRE, Central office (Dr. Vermeulen), Meerstraat 60, Grimbergen, BE 1852, Belgium. FAU - Zondervan, Krina T AU - Zondervan KT AD - University of Oxford, Oxford Endometriosis CaRe Centre, Nuffield Department of Women's & Reproductive Health (Dr. Zondervan), Oxford, Oxfordshire, United Kingdom; University of Oxford, Wellcome Centre for Human Genetics (Dr. Zondervan), Oxford, Oxfordshire, United Kingdom. FAU - Grimbizis, Grigoris AU - Grimbizis G AD - Medical School, Aristotle University of Thessaloniki (Dr. Grimbizis), 1st Dept Obstet Gynecol, Tsimiski 51 Street, Thessaloniki 54623, Greece. FAU - De Wilde, Rudy Leon AU - De Wilde RL AD - Carl von Ossietzky Universitat Oldenburg, University Hospital for Gynecology (Dr. De Wilde), Oldenburg, Germany. Electronic address: rudy-leon.dewilde@pius-hospital.de. LA - eng GR - TCS/18/43/CSO_/Chief Scientist Office/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20211021 PL - United States TA - J Minim Invasive Gynecol JT - Journal of minimally invasive gynecology JID - 101235322 SB - IM MH - Consensus MH - *Endometriosis/diagnosis MH - Female MH - *Fertility Preservation MH - Humans MH - *Infertility MH - Reproductive Techniques, Assisted OTO - NOTNLM OT - Endometriosis OT - endometrioma, excision, ablation, coagulation OT - glossary OT - terminology COIS- Conflict of interest A.W.H. reports grant funding from the MRC, NIHR, CSO, Wellbeing of Women, Roche Diagnostics, Astra Zeneca, Ferring, Charles Wolfson Charitable Trust, Standard Life, Consultancy fees from Roche Diagnostics, AbbVie, Nordic Pharma and Ferring, outside the submitted work. In addition, A.W.H. has a patent Serum biomarker for endometriosis pending. N.P.J. reports personal fees from Abbott, Guerbet, Myovant Sciences, Vifor Pharma, Roche Diagnostics outside the submitted work; he is also President of the World Endometriosis Society and chair of the trust board. S.M. reports grants and personal fees from AbbVie, and personal fees from Roche outside the submitted work. C.T. reports grants, nonfinancial support and other from Merck SA, non-financial support and other from Gedeon Richter, non-financial support from Ferring Pharmaceuticals, outside the submitted work and without private revenue. K.T.Z. reports grants from Bayer Healthcare, MDNA Life Sciences, Roche Diagnostics Inc, Volition Rx, outside the submitted work; she is also a Board member (Secretary) of the World Endometriosis Society and World Endometriosis Research Foundation, Research Advisory Board member of Wellbeing of Women, UK (research charity), and Chair, Research Directions Working Group, World Endometriosis Society. J.P reports personal fees from Hologic, Inc., outside the submitted work; he is also a member of the executive boards of ASRM and SRS. The other authors had nothing to disclose. EDAT- 2021/10/26 06:00 MHDA- 2021/11/17 06:00 CRDT- 2021/10/25 05:51 PHST- 2021/08/17 00:00 [received] PHST- 2021/08/25 00:00 [accepted] PHST- 2021/10/26 06:00 [pubmed] PHST- 2021/11/17 06:00 [medline] PHST- 2021/10/25 05:51 [entrez] AID - S1553-4650(21)01171-7 [pii] AID - 10.1016/j.jmig.2021.08.032 [doi] PST - ppublish SO - J Minim Invasive Gynecol. 2021 Nov;28(11):1849-1859. doi: 10.1016/j.jmig.2021.08.032. Epub 2021 Oct 21.