PMID- 34691176
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 1687-8450 (Print)
IS  - 1687-8469 (Electronic)
IS  - 1687-8450 (Linking)
VI  - 2021
DP  - 2021
TI  - CircPTK2 (hsa_circ_0003221) Contributes to Laryngeal Squamous Cell Carcinoma by 
      the miR-1278/YAP1 Axis.
PG  - 2408384
LID - 10.1155/2021/2408384 [doi]
LID - 2408384
AB  - Laryngeal cancer accounts for 20% of all head and neck malignancies. Laryngeal 
      squamous cell carcinoma (LSCC) is the most common type of laryngeal cancer and is 
      characterized by squamous differentiation, a high mortality rate, and poor 
      prognosis. Accumulating studies have indicated that circular RNAs (circRNAs) are 
      critical regulators in many cancers. CircPTK2 exerts an important regulatory role 
      in several cancers. In this study, we aimed to elucidate the function of circPTK2 
      (hsa_circ_0003221) in LSCC. Through a series of investigations, we discovered 
      that circPTK2 was significantly upregulated in LSCC tissues cells. Functionally, 
      cell counting kit-8 (CCK-8) and flow cytometry analyses revealed that knockdown 
      of circPTK2 suppressed LSCC cell viability and the cell cycle while promoting 
      cell apoptosis. Notably, silencing circPTK2 inhibited tumor growth in vivo. 
      Mechanistically, circPTK2 functioned as a molecular sponge of miR-1278 to 
      upregulate YAP1 expression in LSCC cells. Moreover, YAP1 knockdown inhibited 
      malignant phenotypes of LSCC cells. The rescue experiments showed that YAP1 
      overexpression reversed the effects of circPTK2 on LSCC cells. Therefore, we 
      concluded that circPTK2 facilitates LSCC progression through the miR-1278/YAP1 
      axis.
CI  - Copyright (c) 2021 Zhendong Yang et al.
FAU - Yang, Zhendong
AU  - Yang Z
AUID- ORCID: 0000-0002-3449-3697
AD  - Department of E.N.T, The Ninth People's Hospital of Suzhou, Suzhou 215200, 
      Jiangsu, China.
FAU - Jin, Jianping
AU  - Jin J
AUID- ORCID: 0000-0001-5345-2420
AD  - Department of E.N.T, The Ninth People's Hospital of Suzhou, Suzhou 215200, 
      Jiangsu, China.
FAU - Chang, Tao
AU  - Chang T
AUID- ORCID: 0000-0002-3080-2026
AD  - Department of E.N.T, The Ninth People's Hospital of Suzhou, Suzhou 215200, 
      Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20211013
PL  - Egypt
TA  - J Oncol
JT  - Journal of oncology
JID - 101496537
PMC - PMC8528618
COIS- The authors declare that no conflicts of interest exist in this work.
EDAT- 2021/10/26 06:00
MHDA- 2021/10/26 06:01
PMCR- 2021/10/13
CRDT- 2021/10/25 06:26
PHST- 2021/07/22 00:00 [received]
PHST- 2021/09/08 00:00 [revised]
PHST- 2021/09/15 00:00 [accepted]
PHST- 2021/10/25 06:26 [entrez]
PHST- 2021/10/26 06:00 [pubmed]
PHST- 2021/10/26 06:01 [medline]
PHST- 2021/10/13 00:00 [pmc-release]
AID - 10.1155/2021/2408384 [doi]
PST - epublish
SO  - J Oncol. 2021 Oct 13;2021:2408384. doi: 10.1155/2021/2408384. eCollection 2021.