PMID- 34691993
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2053-714X (Electronic)
IS  - 2095-5138 (Print)
IS  - 2053-714X (Linking)
VI  - 6
IP  - 6
DP  - 2019 Nov
TI  - Sin1-mediated mTOR signaling in cell growth, metabolism and immune response.
PG  - 1149-1162
LID - 10.1093/nsr/nwz171 [doi]
AB  - The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr 
      protein kinase with essential cellular function via processing various 
      extracellular and intracellular inputs. Two distinct multi-protein mTOR complexes 
      (mTORC), mTORC1 and mTORC2, have been identified and well characterized in 
      eukaryotic cells from yeast to human. Sin1, which stands for 
      Sty1/Spc1-interacting protein1, also known as mitogen-activated protein kinase 
      (MAPK) associated protein (MAPKAP)1, is an evolutionarily conserved adaptor 
      protein. Mammalian Sin1 interacts with many cellular proteins, but it has been 
      widely studied as an essential component of mTORC2, and it is crucial not only 
      for the assembly of mTORC2 but also for the regulation of its substrate 
      specificity. In this review, we summarize our current knowledge of the structure 
      and functions of Sin1, focusing specifically on its protein interaction network 
      and its roles in the mTOR pathway that could account for various cellular 
      functions of mTOR in growth, metabolism, immunity and cancer.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of China 
      Science Publishing & Media Ltd.
FAU - Ruan, Chun
AU  - Ruan C
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, and 
      the Minister of Education Key Laboratory of Cell Death and Differentiation, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
FAU - Ouyang, Xinxing
AU  - Ouyang X
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, and 
      the Minister of Education Key Laboratory of Cell Death and Differentiation, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
FAU - Liu, Hongzhi
AU  - Liu H
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, and 
      the Minister of Education Key Laboratory of Cell Death and Differentiation, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
FAU - Li, Song
AU  - Li S
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, and 
      the Minister of Education Key Laboratory of Cell Death and Differentiation, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
FAU - Jin, Jingsi
AU  - Jin J
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, and 
      the Minister of Education Key Laboratory of Cell Death and Differentiation, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
FAU - Tang, Weiyi
AU  - Tang W
AD  - Zhiyuan College, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Xia, Yu
AU  - Xia Y
AD  - Zhiyuan College, Shanghai Jiao Tong University, Shanghai 200240, China.
FAU - Su, Bing
AU  - Su B
AD  - Shanghai Institute of Immunology, Department of Immunology and Microbiology, and 
      the Minister of Education Key Laboratory of Cell Death and Differentiation, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
AD  - Zhiyuan College, Shanghai Jiao Tong University, Shanghai 200240, China.
LA  - eng
PT  - Journal Article
DEP - 20191119
PL  - China
TA  - Natl Sci Rev
JT  - National science review
JID - 101633095
PMC - PMC8291397
OTO - NOTNLM
OT  - AGC kinases
OT  - Akt
OT  - Sin1
OT  - mTOR complex
OT  - metabolism and immune response
EDAT- 2019/11/01 00:00
MHDA- 2019/11/01 00:01
PMCR- 2019/11/19
CRDT- 2021/10/25 06:33
PHST- 2019/09/12 00:00 [received]
PHST- 2019/10/22 00:00 [revised]
PHST- 2019/10/22 00:00 [accepted]
PHST- 2021/10/25 06:33 [entrez]
PHST- 2019/11/01 00:00 [pubmed]
PHST- 2019/11/01 00:01 [medline]
PHST- 2019/11/19 00:00 [pmc-release]
AID - nwz171 [pii]
AID - 10.1093/nsr/nwz171 [doi]
PST - ppublish
SO  - Natl Sci Rev. 2019 Nov;6(6):1149-1162. doi: 10.1093/nsr/nwz171. Epub 2019 Nov 19.