PMID- 34692278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 9
DP  - 2021 Sep
TI  - Heart Failure With Cardiogenic Shock as a Manifestation of Untreated POEMS 
      (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, Skin Changes) 
      Syndrome.
PG  - e18046
LID - 10.7759/cureus.18046 [doi]
LID - e18046
AB  - POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal 
      protein, skin changes) is a rare paraneoplastic syndrome due to a plasma cell 
      disorder. Diagnosis requires peripheral neuropathy and a monoclonal plasma cell 
      disorder along with one major and one minor criteria, but cardiac manifestations 
      are uncommon. The pathogenesis of POEMS syndrome is not well understood but it is 
      thought to involve overproduction of proinflammatory cytokines, such as vascular 
      endothelial growth factor (VEGF), interleukin-1 beta (IL-1B), interleukin-6 
      (IL-6), and tumor necrosis factor-alpha (TNF-alpha). POEMS syndrome commonly 
      presents in the fifth to sixth decade of life, mainly in non-Hispanic Caucasian 
      individuals, and affects more men than women (2:1). We report a unique case of a 
      28-year-old African American female with a history of POEMS syndrome and a new 
      diagnosis of dilated, non-ischemic cardiomyopathy and New York Heart Association 
      (NYHA) class IV, stage D heart failure with an ejection fraction (EF) of 30% as a 
      result of the natural progression of her untreated POEMS syndrome.
CI  - Copyright (c) 2021, Abdelahad et al.
FAU - Abdelahad, Mandi
AU  - Abdelahad M
AD  - Internal Medicine, Nova Southeastern University Dr. Kiran C. Patel College of 
      Osteopathic Medicine, Fort Lauderdale, USA.
FAU - Pearson, Ryan
AU  - Pearson R
AD  - Internal Medicine, Broward Health Medical Center, Fort Lauderdale, USA.
FAU - Mauri, Bryant
AU  - Mauri B
AD  - Internal Medicine, Broward Health Medical Center, Fort Lauderdale, USA.
FAU - Fenton, Kira
AU  - Fenton K
AD  - Internal Medicine, Broward Health Medical Center, Fort Lauderdale, USA.
FAU - Savu, Cristina
AU  - Savu C
AD  - Internal Medicine, Broward Health Medical Center, Fort Lauderdale, USA.
LA  - eng
PT  - Case Reports
DEP - 20210917
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8523341
OTO - NOTNLM
OT  - castleman disease
OT  - heart failure
OT  - hematology
OT  - poems syndrome
OT  - pulmonary hypertension
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/10/26 06:00
MHDA- 2021/10/26 06:01
PMCR- 2021/09/17
CRDT- 2021/10/25 06:35
PHST- 2021/08/02 00:00 [received]
PHST- 2021/09/17 00:00 [accepted]
PHST- 2021/10/25 06:35 [entrez]
PHST- 2021/10/26 06:00 [pubmed]
PHST- 2021/10/26 06:01 [medline]
PHST- 2021/09/17 00:00 [pmc-release]
AID - 10.7759/cureus.18046 [doi]
PST - epublish
SO  - Cureus. 2021 Sep 17;13(9):e18046. doi: 10.7759/cureus.18046. eCollection 2021 
      Sep.