PMID- 34692297
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 9
DP  - 2021 Sep
TI  - Rare Lower Extremity Fibrosarcomatous Variant of Dermatofibrosarcoma With Myxoid 
      Features Treated With Transtibial Amputation.
PG  - e18079
LID - 10.7759/cureus.18079 [doi]
LID - e18079
AB  - Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue tumor 
      originating from the dermis, with high rates of local recurrence and invasive 
      growth but low likelihood of distant metastasis. Fibrosarcomatous transformation 
      (FS-DFSP) of DFSP accounts for approximately 5-15% of DFSP tumors, is a 
      higher-grade tumor, with higher chances of metastasis and poorer prognosis. We 
      present a case of a 66-year-old female presented with a large fungating mass on 
      the left dorsal foot. Ultrasound-guided core needle biopsy with 
      immunohistochemistry suggested a spindle cell neoplasm, favoring myxofibrosarcoma 
      with intermediate grade. The patient elected for below-knee amputation over limb 
      salvage with wide resection and free flap reconstruction. Based on clinical 
      presentation, radiologic, histologic features and fluorescence in situ 
      hybridization (FISH) studies confirmed the diagnosis of fibrosarcomatous variant 
      of dermatofibrosarcoma protuberans with myxoid change. FS-DFSP with myxoid change 
      is a rare soft tissue tumor that requires aggressive treatment due to its high 
      rates of recurrence. This case presents a rare tumor in a unique location that 
      was successfully treated with limb amputation, which is not documented in current 
      literature.
CI  - Copyright (c) 2021, Pryor et al.
FAU - Pryor, Elizabeth K
AU  - Pryor EK
AD  - Orthopedics, Medical College of Georgia - Augusta University, Augusta, USA.
FAU - Sinkler, Margaret A
AU  - Sinkler MA
AD  - Orthopedics, Medical College of Georgia - Augusta University, Augusta, USA.
FAU - Ullah, Asad
AU  - Ullah A
AD  - Pathology, Medical College of Georgia - Augusta University, Augusta, USA.
FAU - Martin, Elizabeth
AU  - Martin E
AD  - Pathology, Medical College of Georgia - Augusta University, Augusta, USA.
FAU - Homlar, Kelly
AU  - Homlar K
AD  - Orthopedic Surgery, Medical College of Georgia - Augusta University, Augusta, 
      USA.
LA  - eng
PT  - Case Reports
DEP - 20210918
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8523476
OTO - NOTNLM
OT  - dermatofibrosarcoma protuberans
OT  - fibrosarcomatous transformation
OT  - immunohistochemistry
OT  - myxoid change
OT  - transtibial amputation
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/10/26 06:00
MHDA- 2021/10/26 06:01
PMCR- 2021/09/18
CRDT- 2021/10/25 06:35
PHST- 2021/09/18 00:00 [accepted]
PHST- 2021/10/25 06:35 [entrez]
PHST- 2021/10/26 06:00 [pubmed]
PHST- 2021/10/26 06:01 [medline]
PHST- 2021/09/18 00:00 [pmc-release]
AID - 10.7759/cureus.18079 [doi]
PST - epublish
SO  - Cureus. 2021 Sep 18;13(9):e18079. doi: 10.7759/cureus.18079. eCollection 2021 
      Sep.