PMID- 34692381
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20211117
IS  - 2211-8179 (Electronic)
IS  - 2211-8160 (Print)
IS  - 2211-8160 (Linking)
VI  - 16
IP  - 1
DP  - 2021
TI  - Incidence, Predictors and Outcomes of Contrast Induced Nephropathy in Patients 
      with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary 
      Intervention.
PG  - 57
LID - 10.5334/gh.1071 [doi]
LID - 57
AB  - BACKGROUND: Contrast induced nephropathy (CIN) is considered one of the most 
      common causes of hospital acquired renal failure and severely affects morbidity 
      and mortality. Our objective was to investigate incidence, predictors and 
      outcomes of CIN in patients with ST elevation myocardial infarction (STEMI) 
      undergoing primary percutaneous coronary intervention (PPCI). METHODS: The study 
      was conducted on 550 patients with STEMI subjected to PPCI. Patients were 
      classified into two groups according to the occurrence of CIN; group I (Patients 
      without CIN) and group II (Patients with CIN). The two groups were assessed for 
      the clinical outcomes including mortality and major adverse cardiac events 
      (MACE). RESULTS: Incidence of CIN was 10.6%, multivariate regression analysis 
      identified the independent predictors of CIN including; age > 60 years OR 6.083 
      (CI95% 3.143-11.77, P = 0.001), presence of diabetes mellitus OR 2.491 (CI95% 
      1.327-4.675, P = 0.005), non-steroidal anti-inflammatory drugs (NSAIDs) use OR 
      2.708 (CI95% 1.393-5.263, P = 0.003), the volume of contrast agent >200 ml OR 
      6.543 (CI95% 3.382-12.65, P = 0.001) and cardiogenic shock OR 4.514 (CI95% 
      1.738-11.72, P = 0.002). Mortality was higher in group II than group I (11.9% vs. 
      4.4% respectively, P = 0.015). The incidence of MACE were higher in group II than 
      group I (heart failure; 18.6% vs. 7.3%, cardiac arrest; 8.5% vs. 2.8% and 
      cardiogenic shock; 16.9% vs. 6.9% with P. value = 0.003, 0.024, 0.007 
      respectively). CONCLUSION: Contrast induced nephropathy was associated with 
      increased morbidity and mortality. The independent predictors of CIN were 
      advanced age, diabetes mellitus, NSAIDs use, the volume of contrast agent >200 ml 
      and cardiogenic shock.
CI  - Copyright: (c) 2021 The Author(s).
FAU - Khalfallah, Mohamed
AU  - Khalfallah M
AD  - Cardiovascular Department, Tanta University, EG.
FAU - Allaithy, Amany
AU  - Allaithy A
AD  - Cardiovascular Department, Tanta University, EG.
FAU - Maria, Dina A
AU  - Maria DA
AD  - Cardiovascular Department, Tanta University, EG.
LA  - eng
PT  - Journal Article
DEP - 20210831
PL  - England
TA  - Glob Heart
JT  - Global heart
JID - 101584391
SB  - IM
MH  - Humans
MH  - Incidence
MH  - *Kidney Diseases/chemically induced/epidemiology
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Risk Factors
MH  - *ST Elevation Myocardial Infarction/epidemiology/surgery
MH  - Treatment Outcome
PMC - PMC8415176
OTO - NOTNLM
OT  - Contrast induced nephropathy
OT  - ST elevation myocardial infarction
OT  - primary percutaneous coronary intervention
COIS- The authors have no competing interests to declare.
EDAT- 2021/10/26 06:00
MHDA- 2021/11/18 06:00
PMCR- 2021/08/31
CRDT- 2021/10/25 06:36
PHST- 2021/05/31 00:00 [received]
PHST- 2021/07/23 00:00 [accepted]
PHST- 2021/10/25 06:36 [entrez]
PHST- 2021/10/26 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2021/08/31 00:00 [pmc-release]
AID - 10.5334/gh.1071 [doi]
PST - epublish
SO  - Glob Heart. 2021 Aug 31;16(1):57. doi: 10.5334/gh.1071. eCollection 2021.