PMID- 34693399
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2688-1152 (Electronic)
IS  - 2688-1152 (Linking)
VI  - 2
IP  - 5
DP  - 2021 Oct
TI  - Characteristics and outcomes of adverse events after COVID-19 vaccination.
PG  - e12565
LID - 10.1002/emp2.12565 [doi]
LID - e12565
AB  - OBJECTIVES: BNT-162b2, mRNA-1273, and Ad26.COV2.S vaccines data regarding adverse 
      events (AEs) are scarce. In this report, we aimed to describe fatal and non-fatal 
      possible AEs after COVID-19 vaccine administration. METHODS: An observational 
      multicenter study investigating the causes of emergency department visits and 
      hospital admissions within 10 days of COVID-19 vaccination. Patients who received 
      first or second doses of COVID-19 vaccines and presented to the emergency 
      department (ED), as well as those admitted to the hospitals or intensive care 
      units (ICUs) were included. Causes of ED, hospital, and ICU admissions and 
      discharges were collected based on the International Classification of Diseases, 
      Tenth Revision (ICD-10) coding system. RESULTS: Between December 2020 and March 
      2021, 1842 patients visited the ED within 10 days of COVID-19 vaccine 
      administration. The mean age was 70.3 years. Overall, 1221 patients presented 
      after the first dose of the vaccine and 653 after the second dose. Trauma 
      (14.9%), hypertensive emergency/urgency (7.8%), generalized pain and arthralgia 
      (5.7%), and chest pain (4.4%) were the most common causes of presentation to the 
      ED. Of all ED presentations, mortality rate was at 2.2% (41 patients) with a 
      median follow-up time of 68.0 days, versus 2.6% in unvaccinated ED patients. 
      Postvaccination acute hypoxemic respiratory failure (46.3%), septic shock 
      (24.4%), and cardiogenic shock (12.2%) were the most common causes of death. 
      CONCLUSION: Although reported AEs are not necessarily caused by the vaccination, 
      this study provides further information about possible AEs after COVID-19 
      immunization, especially those requiring hospital admission. This study also 
      supports prior data that serious AEs post vaccination are much lower than primary 
      COVID-19 infections. Further studies are needed to investigate causalities 
      between vaccines and reported AEs across all age groups.
CI  - (c) 2021 The Authors. JACEP Open published by Wiley Periodicals LLC on behalf of 
      American College of Emergency Physicians.
FAU - Kewan, Tariq
AU  - Kewan T
AD  - Department of Internal Medicine Fairview Hospital Cleveland Clinic Cleveland Ohio 
      USA.
FAU - Flores, Monica
AU  - Flores M
AD  - Department of Internal Medicine Fairview Hospital Cleveland Clinic Cleveland Ohio 
      USA.
FAU - Mushtaq, Komal
AU  - Mushtaq K
AD  - Department of Internal Medicine Fairview Hospital Cleveland Clinic Cleveland Ohio 
      USA.
FAU - Alwakeel, Mahmoud
AU  - Alwakeel M
AD  - Department of Internal Medicine Fairview Hospital Cleveland Clinic Cleveland Ohio 
      USA.
FAU - Burton, Robert
AU  - Burton R
AD  - Department of Business Intelligence Cleveland Clinic Cleveland Ohio USA.
FAU - Campbell, James
AU  - Campbell J
AD  - Department of Coding and Reimbursement Cleveland Clinic Cleveland Ohio USA.
FAU - Perry, Hunter
AU  - Perry H
AD  - Business Operations Coding and Reimbursement Cleveland Clinic Cleveland Ohio USA.
FAU - Al-Jaghbeer, Mohammed
AU  - Al-Jaghbeer M
AD  - Respiratory Institute Pulmonary and Critical Care Medicine Cleveland Clinic 
      Cleveland Ohio USA.
AD  - Cleveland Clinic Lerner College of Medicine of Case Western Reserve University 
      Cleveland Ohio USA.
FAU - Abi Fadel, Francois
AU  - Abi Fadel F
AD  - Respiratory Institute Pulmonary and Critical Care Medicine Cleveland Clinic 
      Cleveland Ohio USA.
AD  - Cleveland Clinic Lerner College of Medicine of Case Western Reserve University 
      Cleveland Ohio USA.
LA  - eng
PT  - Journal Article
DEP - 20211013
PL  - United States
TA  - J Am Coll Emerg Physicians Open
JT  - Journal of the American College of Emergency Physicians open
JID - 101764779
PMC - PMC8514147
OTO - NOTNLM
OT  - BNT-162b2 vaccine
OT  - COVID-19
OT  - hospital admission
OT  - mRNA vaccine
OT  - mRNA-1273 vaccine
OT  - serious adverse events
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/10/26 06:00
MHDA- 2021/10/26 06:01
PMCR- 2021/10/13
CRDT- 2021/10/25 06:49
PHST- 2021/05/24 00:00 [received]
PHST- 2021/07/20 00:00 [revised]
PHST- 2021/08/03 00:00 [accepted]
PHST- 2021/10/25 06:49 [entrez]
PHST- 2021/10/26 06:00 [pubmed]
PHST- 2021/10/26 06:01 [medline]
PHST- 2021/10/13 00:00 [pmc-release]
AID - EMP212565 [pii]
AID - 10.1002/emp2.12565 [doi]
PST - epublish
SO  - J Am Coll Emerg Physicians Open. 2021 Oct 13;2(5):e12565. doi: 
      10.1002/emp2.12565. eCollection 2021 Oct.