PMID- 34693555
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1098-1128 (Electronic)
IS  - 0198-6325 (Linking)
VI  - 42
IP  - 2
DP  - 2022 Mar
TI  - Application or function of citric acid in drug delivery platforms.
PG  - 800-849
LID - 10.1002/med.21864 [doi]
AB  - Nontoxic materials with natural origin are promising materials in the designing 
      and preparation of the new drug delivery systems (DDSs). Today's, citric acid 
      (CA) has attracted a great deal of attention because of its special features; 
      green nature, biocompatibility, low price, biodegradability, and commercially 
      available property. So, CA has been employed in the preparation of the various 
      platforms to induce a suitable property on their structure. Recently, several 
      research groups investigated the CA-based platforms in different forms like 
      tablets, dendrimers, hyperbranched polymers, (co)polymer, hydrogels, and 
      nanoparticles as efficient DDSs. By considering an increasing amount of published 
      articles in this field, for the first time, in this review, an overview of the 
      published works regarding CA applications in the design of various DDSs is 
      presented with a detailed and insightful discussion.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Pooresmaeil, Malihe
AU  - Pooresmaeil M
AD  - Polymer Research Laboratory, Department of Organic and Biochemistry, Faculty of 
      Chemistry, University of Tabriz, Tabriz, Iran.
FAU - Javanbakht, Siamak
AU  - Javanbakht S
AD  - Faculty of Chemistry, Shahid Beheshti University, Tehran, Iran.
FAU - Namazi, Hassan
AU  - Namazi H
AUID- ORCID: 0000-0002-1977-4677
AD  - Polymer Research Laboratory, Department of Organic and Biochemistry, Faculty of 
      Chemistry, University of Tabriz, Tabriz, Iran.
AD  - Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of 
      Medical Science, Tabriz, Iran.
FAU - Shaabani, Ahmad
AU  - Shaabani A
AUID- ORCID: 0000-0002-0304-4434
AD  - Faculty of Chemistry, Shahid Beheshti University, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211025
PL  - United States
TA  - Med Res Rev
JT  - Medicinal research reviews
JID - 8103150
RN  - 0 (Hydrogels)
RN  - 0 (Polymers)
RN  - 2968PHW8QP (Citric Acid)
SB  - IM
MH  - *Citric Acid
MH  - Drug Delivery Systems
MH  - Humans
MH  - Hydrogels
MH  - *Nanoparticles
MH  - Polymers
OTO - NOTNLM
OT  - biomedical
OT  - citric acid
OT  - controlled release
OT  - drug delivery systems
EDAT- 2021/10/26 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/10/25 06:58
PHST- 2021/08/02 00:00 [revised]
PHST- 2021/02/02 00:00 [received]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/26 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/10/25 06:58 [entrez]
AID - 10.1002/med.21864 [doi]
PST - ppublish
SO  - Med Res Rev. 2022 Mar;42(2):800-849. doi: 10.1002/med.21864. Epub 2021 Oct 25.