PMID- 34697671
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220812
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Print)
IS  - 0934-9723 (Linking)
VI  - 41
IP  - 2
DP  - 2022 Feb
TI  - The association of HLA-G polymorphism with oral and genital HPV infection in men.
PG  - 219-226
LID - 10.1007/s10096-021-04362-8 [doi]
AB  - The host genetic factors that influence the natural history of human 
      papillomavirus (HPV) infection in men are not well known. Our aim was to evaluate 
      the role of human leukocyte antigen (HLA)-G polymorphism in oral and genital HPV 
      infection in men. Altogether, 130 men from the Finnish Family HPV Study, with a 
      6-year follow-up, were included in the analyses. HLA-G alleles were tested by 
      direct sequencing. Oral, urethral, and semen samples were collected and analyzed 
      for 24 different HPV genotypes. Unconditional logistic regression was used to 
      determine associations between HLA-G alleles and genotypes with HPV infection and 
      its outcomes. Overall, eight different HLA-G alleles were identified with 15 
      different HLA-G genotype combinations. The most common HLA-G allele among the men 
      was G*01:01:01 (86.2%, n = 112) followed by G*01:01:02 (36.2%, n = 47). Allele 
      G*01:01:02 showed to be protective against any- and high-risk (HR) oral HPV (OR 
      range of 0.20-0.24, 95% CI range of 0.06-0.85). Men having allele G*01:01:01 
      showed a reduced risk for incident (OR 0.30, 95% CI 0.11-0.84) and persistent (OR 
      0.24, 95% CI 0.08-0.69) oral infections. Allele G*01:01:03 was associated with 
      increased risk for urethral HR-HPV infections (OR 4.94, 95% CI 1.34-18.27). Among 
      self-reported demographic data, genotype G*01:01:01/01:01:03 was associated with 
      an increased risk for oral warts (OR 8.00, 95% CI 1.23-51.89) and allele 
      G*01:03:01 increased the risk of pollen and/or animal allergy (OR 13.59, 95% CI 
      1.57-117.25). To conclude, HLA-G polymorphism in men largely impacts the outcome 
      of an oral HPV infection and seems to associate with self-reported allergies.
CI  - (c) 2021. The Author(s).
FAU - Suominen, Nelli T
AU  - Suominen NT
AD  - Department of Obstetrics and Gynecology, Turku University Hospital, University of 
      Turku, Kiinamyllynkatu 4-8, 20521, Turku, Finland. nelli.t.suominen@utu.fi.
FAU - Jaakola, Anna J
AU  - Jaakola AJ
AD  - Department of Obstetrics and Gynecology, Turku University Hospital, University of 
      Turku, Kiinamyllynkatu 4-8, 20521, Turku, Finland.
AD  - Department of Obstetrics and Gynecology, Kymenlaakso Central Hospital, Kotkantie 
      41, 48210, Kotka, Finland.
FAU - Roger, Michel
AU  - Roger M
AD  - Centre de Recherche, Centre Hospitalier de l'Universite de Montreal, 900, rue 
      Saint-Denis, Pavillon R, Montreal, Quebec, H2X 0A9, Canada.
AD  - Departement de Microbiologie, Infectiologie, Immunologie, Universite de Montreal, 
      Roger-Gaudry Building, 2900 Edouard Montpetit Blvd, Montreal, QC, H3T 1J4, 
      Canada.
FAU - Faucher, Marie-Claude
AU  - Faucher MC
AD  - Centre de Recherche, Centre Hospitalier de l'Universite de Montreal, 900, rue 
      Saint-Denis, Pavillon R, Montreal, Quebec, H2X 0A9, Canada.
FAU - Syrjanen, Kari J
AU  - Syrjanen KJ
AD  - Department of Clinical Research, Biohit Oyj, Laippatie 1, 00880, Helsinki, 
      Finland.
FAU - Grenman, Seija E
AU  - Grenman SE
AD  - Department of Obstetrics and Gynecology, Turku University Hospital, University of 
      Turku, Kiinamyllynkatu 4-8, 20521, Turku, Finland.
FAU - Syrjanen, Stina M
AU  - Syrjanen SM
AD  - Department of Oral Pathology and Radiology, University of Turku, Lemminkaisenkatu 
      2, 20520, Turku, Finland.
FAU - Louvanto, Karolina
AU  - Louvanto K
AD  - Department of Oral Pathology and Radiology, University of Turku, Lemminkaisenkatu 
      2, 20520, Turku, Finland.
AD  - Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere 
      University, Finn-Medi 1, Biokatu 6, 33100, Tampere, Finland.
LA  - eng
PT  - Journal Article
DEP - 20211025
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official 
      publication of the European Society of Clinical Microbiology
JID - 8804297
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Finland
MH  - Follow-Up Studies
MH  - Genitalia
MH  - Genotype
MH  - HLA-G Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Papillomaviridae/*genetics
MH  - Papillomavirus Infections/*virology
MH  - *Polymorphism, Genetic
PMC - PMC8770419
OTO - NOTNLM
OT  - Genital
OT  - HLA-G
OT  - HPV
OT  - Human papillomavirus
OT  - Men
OT  - Oral
COIS- The authors declare no competing interests.
EDAT- 2021/10/27 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/10/25
CRDT- 2021/10/26 06:28
PHST- 2021/04/20 00:00 [received]
PHST- 2021/10/04 00:00 [accepted]
PHST- 2021/10/27 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/10/26 06:28 [entrez]
PHST- 2021/10/25 00:00 [pmc-release]
AID - 10.1007/s10096-021-04362-8 [pii]
AID - 4362 [pii]
AID - 10.1007/s10096-021-04362-8 [doi]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2022 Feb;41(2):219-226. doi: 
      10.1007/s10096-021-04362-8. Epub 2021 Oct 25.