PMID- 34698104
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20220716
IS  - 1467-3045 (Electronic)
IS  - 1467-3037 (Print)
IS  - 1467-3037 (Linking)
VI  - 43
IP  - 3
DP  - 2021 Oct 14
TI  - Impact of Vitamin D Supplementation on Inflammatory Markers' Levels in Obese 
      Patients.
PG  - 1606-1622
LID - 10.3390/cimb43030114 [doi]
AB  - In view of research suggesting a possible beneficial impact of vitamin D on 
      systemic inflammatory response, the authors decided to investigate an influence 
      of vitamin D supplementation on serum levels of certain inflammatory markers in 
      obese patients. The current study included such biomarkers as interleukin-6 
      (IL-6), pituitary adenylate cyclase-activating peptide (PACAP), advanced 
      oxidation protein products (AOPP), C-X3-C Motif Chemokine Ligand 1 (CX3CL1), 
      monocyte chemoattractant protein-1 (MCP-1), and nitric oxide (NO). The 
      measurements were performed with the ELISA method before and after 3-month-long 
      supplementation of 2000 IU of vitamin D orally. The results showed that the 
      therapy did not induce any statistically significant changes in serum levels of 
      MCP-1, IL-6, CX3CL1, and PACAP. The supplementation was related to a significant 
      increase in measurements of NO and AOPP levels, although the correlation analysis 
      between vitamin D concentration after its supplementation and the concentration 
      of the molecular parameters did not show significant relation. In conclusion, our 
      study seems to contradict certain aspects of findings available in the literature 
      regarding the vitamin D's impact.
FAU - Wicinski, Michal
AU  - Wicinski M
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Ozorowski, Mateusz
AU  - Ozorowski M
AUID- ORCID: 0000-0003-3401-8738
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Wodkiewicz, Eryk
AU  - Wodkiewicz E
AUID- ORCID: 0000-0002-2834-3414
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
FAU - Otto, Stephan Walter
AU  - Otto SW
AD  - Department of Urology, Raphaelsklinik, 48143 Munster, Germany.
FAU - Kubiak, Karol
AU  - Kubiak K
AD  - Department of Obstetrics and Gynecology, St. Franziskus-Hospital, 48145 Munster, 
      Germany.
FAU - Malinowski, Bartosz
AU  - Malinowski B
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 
      Bydgoszcz, Poland.
LA  - eng
PT  - Journal Article
DEP - 20211014
PL  - Switzerland
TA  - Curr Issues Mol Biol
JT  - Current issues in molecular biology
JID - 100931761
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Biomarkers/*blood
MH  - Body Weights and Measures
MH  - *Dietary Supplements
MH  - Disease Susceptibility
MH  - Female
MH  - *Health Impact Assessment
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Obesity/*blood/diagnosis/etiology
MH  - Organ Size
MH  - Vitamin D/*administration & dosage
PMC - PMC8929128
OTO - NOTNLM
OT  - inflammation
OT  - obesity
OT  - pathways
OT  - pharmacology
OT  - vitamin D
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/27 06:00
MHDA- 2022/02/16 06:00
PMCR- 2021/10/14
CRDT- 2021/10/26 09:23
PHST- 2021/09/16 00:00 [received]
PHST- 2021/10/11 00:00 [revised]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/26 09:23 [entrez]
PHST- 2021/10/27 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/10/14 00:00 [pmc-release]
AID - cimb43030114 [pii]
AID - cimb-43-00114 [pii]
AID - 10.3390/cimb43030114 [doi]
PST - epublish
SO  - Curr Issues Mol Biol. 2021 Oct 14;43(3):1606-1622. doi: 10.3390/cimb43030114.