PMID- 34698129
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211029
IS  - 2039-7275 (Print)
IS  - 2039-7283 (Electronic)
IS  - 2039-7275 (Linking)
VI  - 11
IP  - 4
DP  - 2021 Oct 1
TI  - Local Defence System in Healthy Lungs.
PG  - 728-746
LID - 10.3390/clinpract11040088 [doi]
AB  - BACKGROUND: The respiratory system is one of the main entrance gates for 
      infection. The aim of this work was to compare the appearance of specific mucosal 
      pro-inflammatory and common anti-microbial defence factors in healthy lung 
      tissue, from an ontogenetic point of view. MATERIALS AND METHODS: Healthy lung 
      tissues were collected from 15 patients (three females and 12 males) in the age 
      range from 18 to 86. Immunohistochemistry to human beta defensin 2 (HBD-2), human beta 
      defensin 3 (HBD-3), human beta defensin 4 (HBD-4), cathelicidine (LL-37) and 
      interleukine 17A (IL-17A) were performed. RESULTS: The lung tissue material 
      contained bronchial and lung parenchyma material in which no histological 
      changes, connected with the inflammatory process, were detected. During the 
      study, various statistically significant differences were detected in 
      immunoreactive expression between different factors in all lung tissue 
      structures. CONCLUSION: All healthy lung structures, but especially the 
      cartilage, alveolar epithelium and the alveolar macrophages, are the main 
      locations for the baseline synthesis of antimicrobial proteins and IL-17A. 
      Cartilage shows high functional plasticity of this structure, including 
      significant antimicrobial activity and participation in local lung protection 
      response. Interrelated changes between antimicrobial proteins in different tissue 
      confirm baseline synergistical cooperation of all these factors in healthy lung 
      host defence.
FAU - Lohova, Elizabeta
AU  - Lohova E
AD  - Institute of Anatomy and Anthropology, Riga Stradins University, LV-1010 Riga, 
      Latvia.
FAU - Vitenberga-Verza, Zane
AU  - Vitenberga-Verza Z
AUID- ORCID: 0000-0002-9650-3504
AD  - Institute of Anatomy and Anthropology, Riga Stradins University, LV-1010 Riga, 
      Latvia.
FAU - Kazoka, Dzintra
AU  - Kazoka D
AUID- ORCID: 0000-0003-0816-6446
AD  - Institute of Anatomy and Anthropology, Riga Stradins University, LV-1010 Riga, 
      Latvia.
FAU - Pilmane, Mara
AU  - Pilmane M
AUID- ORCID: 0000-0001-9804-4666
AD  - Institute of Anatomy and Anthropology, Riga Stradins University, LV-1010 Riga, 
      Latvia.
LA  - eng
PT  - Journal Article
DEP - 20211001
PL  - Switzerland
TA  - Clin Pract
JT  - Clinics and practice
JID - 101563282
PMC - PMC8544484
OTO - NOTNLM
OT  - factors
OT  - healthy lungs
OT  - immunity
OT  - local defence
OT  - respiratory system
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/27 06:00
MHDA- 2021/10/27 06:01
PMCR- 2021/10/01
CRDT- 2021/10/26 09:24
PHST- 2021/06/29 00:00 [received]
PHST- 2021/08/23 00:00 [revised]
PHST- 2021/09/08 00:00 [accepted]
PHST- 2021/10/26 09:24 [entrez]
PHST- 2021/10/27 06:00 [pubmed]
PHST- 2021/10/27 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - clinpract11040088 [pii]
AID - clinpract-11-00088 [pii]
AID - 10.3390/clinpract11040088 [doi]
PST - epublish
SO  - Clin Pract. 2021 Oct 1;11(4):728-746. doi: 10.3390/clinpract11040088.