PMID- 34698667
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20220429
IS  - 1531-7080 (Electronic)
IS  - 0268-4705 (Linking)
VI  - 37
IP  - 1
DP  - 2022 Jan 1
TI  - The emerging role of cardiac contractility modulation in heart failure treatment.
PG  - 30-35
LID - 10.1097/HCO.0000000000000929 [doi]
AB  - PURPOSE OF REVIEW: Heart failure often progresses despite optimal medical and 
      device therapies, and advanced mechanical circulatory support has limited 
      availability and substantial associated morbidity. Cardiac contractility 
      modulation (CCM) provides nonexcitatory stimulation to ventricular myocardium 
      which increases cardiac contractility without increasing oxygen demand. This 
      review describes the emerging role of CCM in heart failure treatment. RECENT 
      FINDINGS: The FIX-HF-5C2 study demonstrated similar safety and efficacy profile 
      of the two-lead Optimizer device in comparison with the prior three-lead system, 
      thereby decreasing procedural complexity and minimizing endocardial hardware. The 
      FIX-HF-5C trial underscored the benefit of CCM in patients with mild-moderate 
      left ventricular dysfunction (ejection fraction, 25-45%) with New York Heart 
      Association (NYHA) Class III symptoms. The summarized randomized trial data show 
      consistent improvements in peak VO2, 6-min walk distance, and NYHA functional 
      class with CCM. Future trials are planned to determine the role of CCM in heart 
      failure patients with preserved ejection fraction, obligate ventricular pacing, 
      and atrial arrhythmias. SUMMARY: Nonexcitatory extracellular electric potentials 
      can facilitate inotropic improvements in the failing heart. The mechanism of CCM 
      does not increase myocardial oxygen consumption and has been shown to mitigate 
      heart failure symptoms, decrease hospitalizations, and work in synergy with 
      guideline-directed therapy for heart failure.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Chinyere, Ikeotunye R
AU  - Chinyere IR
AD  - Division of Cardiovascular Medicine, University of Arizona College of Medicine - 
      Tucson, Tucson, Arizona, USA.
FAU - Balakrishnan, Mahesh
AU  - Balakrishnan M
FAU - Hutchinson, Mathew D
AU  - Hutchinson MD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Cardiol
JT  - Current opinion in cardiology
JID - 8608087
SB  - IM
MH  - *Heart Failure
MH  - Humans
MH  - *Myocardial Contraction/physiology
MH  - Stroke Volume/physiology
MH  - Treatment Outcome
MH  - Ventricular Function, Left/physiology
EDAT- 2021/10/27 06:00
MHDA- 2022/04/30 06:00
CRDT- 2021/10/26 12:22
PHST- 2021/10/27 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
PHST- 2021/10/26 12:22 [entrez]
AID - 00001573-202201000-00006 [pii]
AID - 10.1097/HCO.0000000000000929 [doi]
PST - ppublish
SO  - Curr Opin Cardiol. 2022 Jan 1;37(1):30-35. doi: 10.1097/HCO.0000000000000929.