PMID- 34699107
OWN - NLM
STAT- MEDLINE
DCOM- 20220510
LR  - 20220510
IS  - 1938-3673 (Electronic)
IS  - 0741-5400 (Linking)
VI  - 111
IP  - 4
DP  - 2022 Apr
TI  - Gift bags from the sentinel cells of the immune system: The diverse role of 
      dendritic cell-derived extracellular vesicles.
PG  - 903-920
LID - 10.1002/JLB.3RU1220-801R [doi]
AB  - Dendritic cells (DCs) are professional APCs of the immune system that 
      continuously sample their environment and function to stimulate an adaptive 
      immune response by initiating Ag-specific immunity or tolerance. Extracellular 
      vesicles (EVs), small membrane-bound structures, are released from DCs and have 
      been discovered to harbor functional peptide-MHC complexes, T cell costimulatory 
      molecules, and other molecules essential for Ag presentation, immune cell 
      regulation, and stimulating immune responses. As such, DC-derived EVs are being 
      explored as potential immunotherapeutic agents. DC-derived EVs have also been 
      implicated to function as a trafficking mechanism of infectious particles aiding 
      viral propagation. This review will explore the unique features that enable 
      DC-derived EVs to regulate immune responses and interact with recipient cells, 
      their roles within Ag-presentation and disease settings, as well as speculating 
      on a potential immunological role of apoptotic DC-derived EVs.
CI  - (c)2021 Society for Leukocyte Biology.
FAU - Hodge, Amy L
AU  - Hodge AL
AD  - Department of Biochemistry and Genetics, La Trobe Institute for Molecular 
      Science, La Trobe University, Melbourne, Victoria, Australia.
FAU - Baxter, Amy A
AU  - Baxter AA
AD  - Department of Biochemistry and Genetics, La Trobe Institute for Molecular 
      Science, La Trobe University, Melbourne, Victoria, Australia.
FAU - Poon, Ivan K H
AU  - Poon IKH
AD  - Department of Biochemistry and Genetics, La Trobe Institute for Molecular 
      Science, La Trobe University, Melbourne, Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211026
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
SB  - IM
MH  - Adaptive Immunity
MH  - *Dendritic Cells
MH  - *Extracellular Vesicles
MH  - Immune Tolerance
OTO - NOTNLM
OT  - antigen presentation
OT  - apoptosis
OT  - dendritic cells
OT  - exosomes
OT  - extracellular vesicles
OT  - immunomodulation
OT  - immunotherapy
OT  - infection
OT  - intercellular communication
OT  - vaccine
EDAT- 2021/10/27 06:00
MHDA- 2022/05/11 06:00
CRDT- 2021/10/26 12:40
PHST- 2021/10/27 06:00 [pubmed]
PHST- 2022/05/11 06:00 [medline]
PHST- 2021/10/26 12:40 [entrez]
AID - 10.1002/JLB.3RU1220-801R [doi]
PST - ppublish
SO  - J Leukoc Biol. 2022 Apr;111(4):903-920. doi: 10.1002/JLB.3RU1220-801R. Epub 2021 
      Oct 26.