PMID- 34700293
OWN - NLM
STAT- MEDLINE
DCOM- 20220308
LR  - 20220308
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 15
IP  - 6
DP  - 2021 Nov-Dec
TI  - Risk factors associated with the development of diabetic kidney disease in 
      Sudanese patients with type 2 diabetes mellitus: A case-control study.
PG  - 102320
LID - S1871-4021(21)00340-4 [pii]
LID - 10.1016/j.dsx.2021.102320 [doi]
AB  - BACKGROUND AND AIMS: Limited data are available regarding the risk factors 
      associated with the development of diabetic kidney disease (DKD) among Sudanese 
      adults with type 2 diabetes mellitus (T2DM). METHODS: A case-control study was 
      conducted at Dr. Salma Center for Kidney Diseases between April and September 
      2019. Patients with T2DM and DKD were compared to age and sex-matched T2DM 
      patients with no kidney disease (NKD). Socio-demographic features, clinical 
      findings, and laboratory investigations of the study subjects and controls were 
      analyzed using SPSS. RESULTS: A total of 372 patients with DKD were compared to 
      364 T2DM patients with NKD. The mean age of the DKD patients was 58 +/- 13.4 years, 
      their median eGFR was 37.3 +/- 4.9 ml/min/1.73 m(2); they had their T2DM at a 
      significantly younger age compared to controls (P = 0.014). Logistic regression 
      analysis revealed that a family history of diabetes mellitus, a family history of 
      chronic kidney disease, the presence of hypertension, obesity, 
      hypercholesterolemia, hyperuricemia, smoking, recurrent urinary tract infection, 
      and the regular use of non-steroidal anti-inflammatory drugs were significantly 
      associated with the development of DKD (P values < 0.05). CONCLUSION: A series of 
      modifiable risk factors were found to be significant determinants for developing 
      DKD. Primary care physicians are expected to pay considerable attention to their 
      control.
CI  - Copyright (c) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Shigidi, Mazin Mt
AU  - Shigidi MM
AD  - Department of Internal Medicine, College of Medicine, Jouf University, Saudi 
      Arabia. Electronic address: mmshigidi@ju.edu.sa.
FAU - Karrar, Wieam N
AU  - Karrar WN
AD  - Dr. Salma Center for Kidney Diseases, University of Khartoum, Khartoum, Sudan.
LA  - eng
PT  - Journal Article
DEP - 20211020
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/*epidemiology
MH  - Diabetic Nephropathies/*blood/diagnosis/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sudan/epidemiology
OTO - NOTNLM
OT  - Diabetic kidney disease
OT  - Risk factors
OT  - Sudan
COIS- Declaration of competing interest The authors have no conflict of interest to 
      declare.
EDAT- 2021/10/27 06:00
MHDA- 2022/03/09 06:00
CRDT- 2021/10/26 20:30
PHST- 2021/08/20 00:00 [received]
PHST- 2021/10/17 00:00 [revised]
PHST- 2021/10/19 00:00 [accepted]
PHST- 2021/10/27 06:00 [pubmed]
PHST- 2022/03/09 06:00 [medline]
PHST- 2021/10/26 20:30 [entrez]
AID - S1871-4021(21)00340-4 [pii]
AID - 10.1016/j.dsx.2021.102320 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2021 Nov-Dec;15(6):102320. doi: 10.1016/j.dsx.2021.102320. 
      Epub 2021 Oct 20.