PMID- 34700314
OWN - NLM
STAT- MEDLINE
DCOM- 20220126
LR  - 20220126
IS  - 1361-6498 (Electronic)
IS  - 0952-4746 (Linking)
VI  - 42
IP  - 1
DP  - 2022 Jan 18
TI  - Protection and safety of a repeated dosage of KI for iodine thyroid blocking 
      during pregnancy.
LID - 10.1088/1361-6498/ac336e [doi]
AB  - In case of nuclear power plant accidents resulting in the release of radioactive 
      iodine ((131)I) in large amounts, a single intake of stable iodine is recommended 
      in order to prevent(131)I fixation to the thyroid gland. However, in situations 
      of prolonged exposure to(131)I (e.g. Fukushima-Daiichi natural and nuclear 
      disaster), repetitive administration of iodine may be necessary to ensure 
      adequate protection, with acceptable safety in vulnerable populations including 
      pregnant women. Here we conducted toxicological studies on adult rats progeny 
      following prolonged exposure to potassium iodide (KI)in utero. Pregnant Wistar 
      rats were treated with 1 mg kg d(-1)KI or saline water for 2 or 4 d either 
      between gestation days gestational day (GD) GD 9-12, or GD13-16. Plasma samples 
      from the progeny were tested 30 d post-weaning for clinical biochemistry, thyroid 
      hormones, and anti-thyroid antibody levels. Thyroid and brain were collected for 
      gene expression analysis. The hormonal status was similar for the mothers in all 
      experimental conditions. In the offspring, while thyroid-stimulating hormone and 
      anti-thyroid peroxidase (anti-TPO) antibody levels were similar in all groups, a 
      significant increase of FT3 and FT4 levels was observed in GD9-GD10 and in 
      GD13-GD14 animals treated for 2 d, respectively. In addition, FT4 levels were 
      mildly decreased in 4 d treated GD13-16 individuals. Moreover, a significant 
      decrease in the expression level of thyroid genes involved in iodide metabolism, 
      TPO and apical iodide transporter, was observed in GD13-GD14 animals treated for 
      2 d. We conclude that repeated KI administration for 2-4 d during gestation did 
      not induce strong thyroid toxicity.
CI  - Creative Commons Attribution license.
FAU - Gaouaoui-Azouaou, Hayat
AU  - Gaouaoui-Azouaou H
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - L'Homme, Bruno
AU  - L'Homme B
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Benadjaoud, Mohamed Amine
AU  - Benadjaoud MA
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Sache-Aloui, Amandine
AU  - Sache-Aloui A
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Granger, Romain
AU  - Granger R
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Voyer, Frederic
AU  - Voyer F
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Lestaevel, Philippe
AU  - Lestaevel P
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Gruel, Gaetan
AU  - Gruel G
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Caire-Maurisier, Francois
AU  - Caire-Maurisier F
AD  - Pharmacie Centrale des Armees, Direction des Approvisionnement en produits de 
      sante des armees, 45404 Fleury-les Aubrais, France.
FAU - Crambes, Caroline
AU  - Crambes C
AD  - Pharmacie Centrale des Armees, Direction des Approvisionnement en produits de 
      sante des armees, 45404 Fleury-les Aubrais, France.
FAU - Dare-Doyen, Stephanie
AU  - Dare-Doyen S
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Benderitter, Marc
AU  - Benderitter M
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
FAU - Souidi, Maamar
AU  - Souidi M
AUID- ORCID: 0000-0001-8269-9676
AD  - Institut de radioprotection et de surete Nucleaire (IRSN), PSE-SANTE, 92290 
      Fontenay-aux-Roses, France.
LA  - eng
PT  - Journal Article
DEP - 20220118
PL  - England
TA  - J Radiol Prot
JT  - Journal of radiological protection : official journal of the Society for 
      Radiological Protection
JID - 8809257
RN  - 0 (Iodides)
RN  - 0 (Iodine Radioisotopes)
RN  - 1C4QK22F9J (Potassium Iodide)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Iodides
MH  - *Iodine
MH  - Iodine Radioisotopes
MH  - Potassium Iodide
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - *Thyroid Neoplasms
OTO - NOTNLM
OT  - gestation
OT  - iodine thyroid blocking
OT  - nuclear accident
OT  - potassium iodine
OT  - progeny
OT  - thyroid hormones
EDAT- 2021/10/27 06:00
MHDA- 2022/01/27 06:00
CRDT- 2021/10/26 20:31
PHST- 2021/09/07 00:00 [received]
PHST- 2021/10/26 00:00 [accepted]
PHST- 2021/10/27 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/10/26 20:31 [entrez]
AID - 10.1088/1361-6498/ac336e [doi]
PST - epublish
SO  - J Radiol Prot. 2022 Jan 18;42(1). doi: 10.1088/1361-6498/ac336e.