PMID- 34702775
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220328
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 70
IP  - 2
DP  - 2022 Feb
TI  - N-terminal pro-brain natriuretic peptide is an independent predictor of mortality 
      in patients with sepsis.
PG  - 369-375
LID - 10.1136/jim-2021-002017 [doi]
AB  - This study aims to evaluate the role of cardiac enzymes N-terminal pro-brain 
      natriuretic peptide (NT-proBNP) and cardiac troponin-I (CTnI) as predictors of 
      outcomes in patients with sepsis.78 cases with a diagnosis of sepsis were 
      enrolled over a 2-year period. Baseline demographic, Acute Physiology and Chronic 
      Health Evaluation-II (APACHE-II), Simplified Acute Physiology Score-II (SAPS-II), 
      hematologic and biochemical parameters were noted. Serum NT-proBNP and CTnI were 
      evaluated at 24 and 72 hours of admission along with echocardiography. Patients 
      were prospectively followed up until death or discharge.Mean APACHE-II score was 
      19.8+/-9.6 and SAPS-II was 44.8+/-17.2. Survival rate in the study was 47.5% (36 of 
      78 patients). NT-proBNP was significantly higher in non-survivors with values 
      over 4300 pg/mL at 24 hours and 5229 pg/mL at 72 hours associated with poor 
      outcomes (p<0.05). CTnI was higher among non-survivors than in survivors, but the 
      difference was not significant. APACHE-II score combined with NT-proBNP predicted 
      a poor outcome in 51.2% cases compared with 14.6% cases with APACHE-II alone 
      (p<0.05), while SAPS-II combined with NT-proBNP predicted a poor outcome in 53.6% 
      cases as compared with 9.6% cases with SAPS-II alone (p<0.05). SAPS-II greater 
      than 45 and NT-proBNP values at 72 hours were independent predictors of mortality 
      in patients with sepsis.NT-proBNP is an independent predictor of mortality in 
      patients with sepsis and its combination with APACHE-II and SAPS-II improves the 
      predictive values of the scoring systems.
CI  - (c) American Federation for Medical Research 2022. No commercial re-use. See rights 
      and permissions. Published by BMJ.
FAU - Biswas, Sagnik
AU  - Biswas S
AUID- ORCID: 0000-0003-3487-4921
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Soneja, Manish
AU  - Soneja M
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi, India 
      manishsoneja@gmail.com.
FAU - Makkar, Nayani
AU  - Makkar N
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Farooqui, Faraz Ahmed
AU  - Farooqui FA
AD  - Department of Cardiology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Roy, Ambuj
AU  - Roy A
AD  - Department of Cardiology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Kumar, Arvind
AU  - Kumar A
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Nischal, Neeraj
AU  - Nischal N
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Biswas, Ashutosh
AU  - Biswas A
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Wig, Naveet
AU  - Wig N
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Sood, Rita
AU  - Sood R
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Sreenivas, Vishnubhatla
AU  - Sreenivas V
AD  - Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 
      India.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20211026
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Troponin I)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Prospective Studies
MH  - Sepsis/blood/*mortality
MH  - Troponin I/*blood
OTO - NOTNLM
OT  - biomarkers
OT  - critical care
OT  - sepsis
COIS- Competing interests: None declared.
EDAT- 2021/10/28 06:00
MHDA- 2022/03/29 06:00
CRDT- 2021/10/27 06:13
PHST- 2021/09/28 00:00 [accepted]
PHST- 2021/10/28 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/10/27 06:13 [entrez]
AID - jim-2021-002017 [pii]
AID - 10.1136/jim-2021-002017 [doi]
PST - ppublish
SO  - J Investig Med. 2022 Feb;70(2):369-375. doi: 10.1136/jim-2021-002017. Epub 2021 
      Oct 26.