PMID- 34703276
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 1178-7031 (Print)
IS  - 1178-7031 (Electronic)
IS  - 1178-7031 (Linking)
VI  - 14
DP  - 2021
TI  - Ferroptosis is Involved in Hyperoxic Lung Injury in Neonatal Rats.
PG  - 5393-5401
LID - 10.2147/JIR.S335061 [doi]
AB  - PURPOSE: To evaluate whether ferroptosis is involved in hyperoxic acute lung 
      injury (HALI) and its mechanisms through the HALI model. METHODS: HE staining was 
      used to assess lung injury pathology after the establishment of neonatal rat HALI 
      model. ELISA was used to detect ROS, GPX4, and GSH expression. Prussian blue 
      staining and Western Blot were used to detect iron deposition and the expression 
      of ferroptosis-related proteins, respectively. RESULTS: The HALI group showed 
      pathological changes with larger and fewer alveoli and thicker alveolar septa 
      after HE staining. Prussian blue staining detected significant iron deposition in 
      the lung tissue of the HALI group. GPX4, GSH, GSS, and SLC7A11 expressions were 
      significantly decreased in the HALI group than in the normal control group. In 
      contrast, ROS, TFRC, FHC, and FLC expressions showed opposite results (p<0.05). 
      CONCLUSION: Ferroptosis may be involved in the pathological process of hyperoxic 
      lung injury in neonatal rats.
CI  - (c) 2021 Jia et al.
FAU - Jia, Danyun
AU  - Jia D
AUID- ORCID: 0000-0003-4576-9430
AD  - Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, People's Republic of China.
FAU - Zheng, Jinyu
AU  - Zheng J
AD  - Department of Clinical Medicine, Wenzhou Medical University, Wenzhou, 325000, 
      Zhejiang, People's Republic of China.
FAU - Zhou, Yiyang
AU  - Zhou Y
AD  - Department of Clinical Medicine, Wenzhou Medical University, Wenzhou, 325000, 
      Zhejiang, People's Republic of China.
FAU - Jia, Jinqiu
AU  - Jia J
AD  - Department of Pediatric, Taizhou Women and Children's Hospital of Wenzhou Medical 
      University, Taizhou, 317599, Zhejiang, People's Republic of China.
FAU - Ye, Xiaoxiao
AU  - Ye X
AUID- ORCID: 0000-0001-6898-5879
AD  - Department of Nursing, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, People's Republic of China.
FAU - Zhou, Bingbing
AU  - Zhou B
AD  - Department of Nursing, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, People's Republic of China.
FAU - Chen, Xingxing
AU  - Chen X
AUID- ORCID: 0000-0002-6945-7688
AD  - Department of Nursing, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, People's Republic of China.
FAU - Mo, Yunchang
AU  - Mo Y
AD  - Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, People's Republic of China.
FAU - Wang, Junlu
AU  - Wang J
AD  - Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, Zhejiang, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20211018
PL  - New Zealand
TA  - J Inflamm Res
JT  - Journal of inflammation research
JID - 101512684
PMC - PMC8536887
OTO - NOTNLM
OT  - ferroptosis
OT  - hyperoxic lung injury
OT  - neonatal rats
COIS- Danyun Jia, Jinyu Zheng and Yiyang Zhou contributed equally to this work and 
      should be considered co-first authors. The authors declare no conflict of 
      interest.
EDAT- 2021/10/28 06:00
MHDA- 2021/10/28 06:01
PMCR- 2021/10/18
CRDT- 2021/10/27 07:04
PHST- 2021/08/19 00:00 [received]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/10/27 07:04 [entrez]
PHST- 2021/10/28 06:00 [pubmed]
PHST- 2021/10/28 06:01 [medline]
PHST- 2021/10/18 00:00 [pmc-release]
AID - 335061 [pii]
AID - 10.2147/JIR.S335061 [doi]
PST - epublish
SO  - J Inflamm Res. 2021 Oct 18;14:5393-5401. doi: 10.2147/JIR.S335061. eCollection 
      2021.