PMID- 34706780
OWN - NLM
STAT- MEDLINE
DCOM- 20220114
LR  - 20231102
IS  - 1756-3305 (Electronic)
IS  - 1756-3305 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Oct 27
TI  - On the role of dauer in the adaptation of nematodes to a parasitic lifestyle.
PG  - 554
LID - 10.1186/s13071-021-04953-6 [doi]
LID - 554
AB  - Nematodes are presumably the most abundant Metazoa on Earth, and can even be 
      found in some of the most hostile environments of our planet. Various types of 
      hypobiosis evolved to adapt their life cycles to such harsh environmental 
      conditions. The five most distal major clades of the phylum Nematoda (Clades 
      8-12), formerly referred to as the Secernentea, contain many economically 
      relevant parasitic nematodes. In this group, a special type of hypobiosis, dauer, 
      has evolved. The dauer signalling pathway, which culminates in the biosynthesis 
      of dafachronic acid (DA), is intensively studied in the free-living nematode 
      Caenorhabditis elegans, and it has been hypothesized that the dauer stage may 
      have been a prerequisite for the evolution of a wide range of parasitic 
      lifestyles among other nematode species. Biosynthesis of DA is not specific for 
      hypobiosis, but if it results in exit of the hypobiotic state, it is one of the 
      main criteria to define certain behaviour as dauer. Within Clades 9 and 10, the 
      involvement of DA has been validated experimentally, and dauer is therefore 
      generally accepted to occur in those clades. However, for other clades, such as 
      Clade 12, this has hardly been explored. In this review, we provide clarity on 
      the nomenclature associated with hypobiosis and dauer across different 
      nematological subfields. We discuss evidence for dauer-like stages in Clades 8 to 
      12 and support this with a meta-analysis of available genomic data. Furthermore, 
      we discuss indications for a simplified dauer signalling pathway in parasitic 
      nematodes. Finally, we zoom in on the host cues that induce exit from the 
      hypobiotic stage and introduce two hypotheses on how these signals might feed 
      into the dauer signalling pathway for plant-parasitic nematodes. With this work, 
      we contribute to the deeper understanding of the molecular mechanisms underlying 
      hypobiosis in parasitic nematodes. Based on this, novel strategies for the 
      control of parasitic nematodes can be developed.
CI  - (c) 2021. The Author(s).
FAU - Vlaar, Lieke E
AU  - Vlaar LE
AD  - Plant Hormone Biology Group, Green Life Sciences Cluster, Swammerdam Institute 
      for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, 
      The Netherlands.
FAU - Bertran, Andre
AU  - Bertran A
AD  - Laboratory of Nematology, Department of Plant Sciences, Wageningen University, 
      6708 PB, Wageningen, The Netherlands.
FAU - Rahimi, Mehran
AU  - Rahimi M
AD  - Plant Hormone Biology Group, Green Life Sciences Cluster, Swammerdam Institute 
      for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, 
      The Netherlands.
FAU - Dong, Lemeng
AU  - Dong L
AD  - Plant Hormone Biology Group, Green Life Sciences Cluster, Swammerdam Institute 
      for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, 
      The Netherlands.
FAU - Kammenga, Jan E
AU  - Kammenga JE
AD  - Laboratory of Nematology, Department of Plant Sciences, Wageningen University, 
      6708 PB, Wageningen, The Netherlands.
FAU - Helder, Johannes
AU  - Helder J
AD  - Laboratory of Nematology, Department of Plant Sciences, Wageningen University, 
      6708 PB, Wageningen, The Netherlands.
FAU - Goverse, Aska
AU  - Goverse A
AD  - Laboratory of Nematology, Department of Plant Sciences, Wageningen University, 
      6708 PB, Wageningen, The Netherlands.
FAU - Bouwmeester, Harro J
AU  - Bouwmeester HJ
AD  - Plant Hormone Biology Group, Green Life Sciences Cluster, Swammerdam Institute 
      for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, 
      The Netherlands. h.j.bouwmeester@uva.nl.
LA  - eng
GR  - CHEMCOMRHIZO, 670211/ERC_/European Research Council/International
GR  - 16873/NWO-TTW/
GR  - NemHatch, 793795/H2020 Marie Sklodowska-Curie Actions/
PT  - Journal Article
PT  - Review
DEP - 20211027
PL  - England
TA  - Parasit Vectors
JT  - Parasites & vectors
JID - 101462774
RN  - 0 (Cholestenes)
RN  - 0 (dafachronic acid)
SB  - IM
MH  - *Adaptation, Physiological
MH  - Animals
MH  - Caenorhabditis elegans/genetics/metabolism
MH  - Cholestenes/*metabolism
MH  - Gene Expression Regulation, Developmental
MH  - *Life Cycle Stages
MH  - Nematoda/classification/genetics/*growth & development/*physiology
MH  - *Signal Transduction
PMC - PMC8555053
OTO - NOTNLM
OT  - Clade 12
OT  - Dauer
OT  - Globodera
OT  - Parasitic nematodes
OT  - Quiescence
COIS- The authors declare that they have no competing interests.
EDAT- 2021/10/29 06:00
MHDA- 2022/01/15 06:00
PMCR- 2021/10/27
CRDT- 2021/10/28 05:35
PHST- 2021/04/19 00:00 [received]
PHST- 2021/08/13 00:00 [accepted]
PHST- 2021/10/28 05:35 [entrez]
PHST- 2021/10/29 06:00 [pubmed]
PHST- 2022/01/15 06:00 [medline]
PHST- 2021/10/27 00:00 [pmc-release]
AID - 10.1186/s13071-021-04953-6 [pii]
AID - 4953 [pii]
AID - 10.1186/s13071-021-04953-6 [doi]
PST - epublish
SO  - Parasit Vectors. 2021 Oct 27;14(1):554. doi: 10.1186/s13071-021-04953-6.