PMID- 34707050
OWN - NLM
STAT- MEDLINE
DCOM- 20220603
LR  - 20220817
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 61
IP  - 11
DP  - 2022 Jun 1
TI  - Differentiating Dementia with Lewy Bodies from Alzheimer's Disease Using the Fall 
      Risk Evaluation Questionnaire.
PG  - 1687-1692
LID - 10.2169/internalmedicine.8383-21 [doi]
AB  - Objective Dementia with Lewy bodies (DLB) is the second-most common form of 
      neurodegenerative dementia after Alzheimer's disease (AD). Falls are a vital 
      prognostic factor in patients with dementia and are a characteristic feature of 
      DLB. This study investigated the screening potential of the fall risk evaluation 
      for DLB and compared it with that of AD to facilitate an accurate diagnosis. 
      Methods We enrolled patients diagnosed with DLB (n=410) and AD (n=2,683) and 
      categorized the participants into 3 groups depending on their physical ability, 
      age, cognitive function, and fall events. Using the Fall Risk Index-21 (FRI-21) 
      questionnaire, we evaluated and comparatively analyzed the fall risk between DLB 
      and AD patients in three defined groups of participants. Results The FRI-21 score 
      was significantly higher in DLB patients than in AD patients in every group. 
      Using this score, we were able to distinguish between DLB and AD patients in each 
      group. Among the three groups, the group with a young age, relatively mild 
      cognitive dysfunction, and no fall events exhibited the best specificity for DLB 
      (0.895). Conclusions The FRI-21 is a useful tool for screening for DLB and 
      differentiating it from AD. This questionnaire can be used at a relatively early 
      stage of the disease in young patients with mild cognitive dysfunction and no 
      history of falling. These preliminary results need to be validated in an 
      interventional study to evaluate the effectiveness of rehabilitative measures and 
      daily environmental changes carried out to prevent falls using this tool.
FAU - Tsujimoto, Masashi
AU  - Tsujimoto M
AD  - Innovation Center for Translational Research, National Center for Geriatrics and 
      Gerontology, Japan.
FAU - Suzuki, Keisuke
AU  - Suzuki K
AD  - Innovation Center for Translational Research, National Center for Geriatrics and 
      Gerontology, Japan.
FAU - Takeda, Akinori
AU  - Takeda A
AD  - Center for Comprehensive Care and Research on Memory Disorders, National Center 
      for Geriatrics and Gerontology, Japan.
FAU - Saji, Naoki
AU  - Saji N
AD  - Center for Comprehensive Care and Research on Memory Disorders, National Center 
      for Geriatrics and Gerontology, Japan.
FAU - Sakurai, Takashi
AU  - Sakurai T
AD  - Center for Comprehensive Care and Research on Memory Disorders, National Center 
      for Geriatrics and Gerontology, Japan.
FAU - Washimi, Yukihiko
AU  - Washimi Y
AD  - Center for Comprehensive Care and Research on Memory Disorders, National Center 
      for Geriatrics and Gerontology, Japan.
LA  - eng
PT  - Journal Article
DEP - 20211026
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
CIN - Intern Med. 2022 Aug 15;61(16):2557. PMID: 35110498
MH  - *Alzheimer Disease/diagnosis
MH  - *Cognitive Dysfunction/diagnosis
MH  - Diagnosis, Differential
MH  - Humans
MH  - *Lewy Body Disease/diagnosis
MH  - Surveys and Questionnaires
PMC - PMC9259302
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Lewy body disease
OT  - falls
COIS- The authors state that they have no Conflict of Interest (COI).
EDAT- 2021/10/29 06:00
MHDA- 2022/06/07 06:00
PMCR- 2022/06/01
CRDT- 2021/10/28 05:51
PHST- 2021/10/29 06:00 [pubmed]
PHST- 2022/06/07 06:00 [medline]
PHST- 2021/10/28 05:51 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 10.2169/internalmedicine.8383-21 [doi]
PST - ppublish
SO  - Intern Med. 2022 Jun 1;61(11):1687-1692. doi: 10.2169/internalmedicine.8383-21. 
      Epub 2021 Oct 26.