PMID- 34707878
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2051-3380 (Print)
IS  - 2051-3380 (Electronic)
IS  - 2051-3380 (Linking)
VI  - 9
IP  - 11
DP  - 2021 Nov
TI  - Spontaneous improvement of interstitial pneumonia with autoimmune features: A 
      case report.
PG  - e0867
LID - 10.1002/rcr2.867 [doi]
LID - e0867
AB  - Interstitial pneumonia with autoimmune features (IPAF) was proposed to describe 
      patients with interstitial lung disease who do not meet the classification 
      criteria for a defined connective tissue disease. Here, we report a spontaneous 
      improvement case of IPAF. A 58-year-old man developed dry cough and dyspnoea. 
      Positive result was obtained for the anti-centromere antibody. High-resolution 
      computed tomography (HRCT) showed reticular abnormalities and ground-glass 
      opacities. Cryobiopsy specimens revealed cellular non-specific interstitial 
      pneumonia. The patient displayed periungual erythema and nail fold bleeding, but 
      no sclerosis. He did not meet the criteria for systemic scleroderma, but did meet 
      those for IPAF. Because symptoms slightly improved, the patient declined 
      immunosuppressive treatment. After 6 months, repeated HRCT showed an apparent 
      reduction in the area of ground-glass opacities. The forced vital capacity 
      improved from 2.72 to 3.47 L and serum Krebs von den Lungen (KL)-6 decreased from 
      1977 to 531 U/ml, and symptoms disappeared.
CI  - (c) 2021 The Authors. Respirology Case Reports published by John Wiley & Sons 
      Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
FAU - Ohkubo, Hirotsugu
AU  - Ohkubo H
AUID- ORCID: 0000-0002-8538-1150
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City 
      University Graduate School of Medical Sciences Nagoya Japan.
FAU - Nakano, Akiko
AU  - Nakano A
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City 
      University Graduate School of Medical Sciences Nagoya Japan.
FAU - Fujita, Kohei
AU  - Fujita K
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City 
      University Graduate School of Medical Sciences Nagoya Japan.
FAU - Ozawa, Yoshiyuki
AU  - Ozawa Y
AD  - Department of Radiology Nagoya City University Graduate School of Medical 
      Sciences Nagoya Japan.
FAU - Murase, Takayuki
AU  - Murase T
AD  - Department of Pathology and Molecular Diagnostics Nagoya City University Graduate 
      School of Medical Sciences Nagoya Japan.
FAU - Niimi, Akio
AU  - Niimi A
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City 
      University Graduate School of Medical Sciences Nagoya Japan.
LA  - eng
PT  - Case Reports
DEP - 20211019
PL  - United States
TA  - Respirol Case Rep
JT  - Respirology case reports
JID - 101631052
PMC - PMC8524667
OTO - NOTNLM
OT  - interstitial pneumonia with autoimmune features
OT  - non-specific interstitial pneumonia
OT  - transbronchial cryobiopsy
COIS- None declared.
EDAT- 2021/10/29 06:00
MHDA- 2021/10/29 06:01
PMCR- 2021/10/19
CRDT- 2021/10/28 06:40
PHST- 2021/06/06 00:00 [received]
PHST- 2021/08/07 00:00 [revised]
PHST- 2021/09/30 00:00 [accepted]
PHST- 2021/10/28 06:40 [entrez]
PHST- 2021/10/29 06:00 [pubmed]
PHST- 2021/10/29 06:01 [medline]
PHST- 2021/10/19 00:00 [pmc-release]
AID - RCR2867 [pii]
AID - 10.1002/rcr2.867 [doi]
PST - epublish
SO  - Respirol Case Rep. 2021 Oct 19;9(11):e0867. doi: 10.1002/rcr2.867. eCollection 
      2021 Nov.