PMID- 34708095
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211030
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Development and Validation of Risk Prediction Model for New-Onset Diabetes After 
      Percutaneous Coronary Intervention (NODAP): A Study Protocol for a Retrospective, 
      Multicenter Analysis.
PG  - 748256
LID - 10.3389/fcvm.2021.748256 [doi]
LID - 748256
AB  - Background: Type 2 Diabetes mellitus (T2DM) is a major risk factor for 
      cardiovascular diseases and increase mortality. Clinical outcomes of patients 
      after percutaneous coronary intervention (PCI) were worse in T2DM patients than 
      those without T2DM. New-onset diabetes after PCI (NODAP) is often observed during 
      long-term follow-up and this further aggravates cardiovascular diseases. Several 
      studies had focused on patients after PCI with known T2DM. Previous studies 
      showed that impaired glucose tolerance and aging are risk factors that promote 
      NODAP. Considering the unique characteristics of patients after PCI, we will 
      further study relevant risk factors. We sought to investigate the potential 
      predictors of acute coronary syndrome patients with NODAP by a multicenter 
      retrospective cohort study. Methods: This is a multicenter retrospective cohort 
      study including patients after PCI. Clinical medical records of these patients 
      were collected from four hospitals in different areas in China, from 2010 to 
      2021. Patients' demographic information, medical history, diagnostic testing, 
      PCI-related information, medication situation will be summarized using 
      descriptive statistics, and correlation analysis was performed on the development 
      of new-onset diabetes. Variation will be described and evaluated using chi(2) test 
      or Kreskas-Wallis test. The prediction model will be verified by a validation 
      set. Discussion: A novel diabetes prediction model for patients after PCI is 
      established, and this study can achieve advanced intervention for the occurrence 
      of NODAP. Owing to its retrospective nature, this study has some limitations, but 
      it will be further studied through supplement data collection or prospective 
      study. The study has been registered for clinical trials by the Chinese Clinical 
      Trial Registry (ChiCTR2100047241).
CI  - Copyright (c) 2021 Li, Cui, Liu, Chen, Huang and Liu.
FAU - Li, Yiwen
AU  - Li Y
AD  - National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China 
      Academy of Chinese Medical Sciences, Beijing, China.
FAU - Cui, Jing
AU  - Cui J
AD  - National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China 
      Academy of Chinese Medical Sciences, Beijing, China.
FAU - Liu, Yanfei
AU  - Liu Y
AD  - The Second Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Chen, Keji
AU  - Chen K
AD  - National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China 
      Academy of Chinese Medical Sciences, Beijing, China.
FAU - Huang, Luqi
AU  - Huang L
AD  - China Center for Evidence-based Medicine of TCM, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Liu, Yue
AU  - Liu Y
AD  - National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China 
      Academy of Chinese Medical Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20211011
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8542850
OTO - NOTNLM
OT  - cardiovascular disease
OT  - new-onset diabetes
OT  - percutaneous coronary intervention
OT  - prediction model
OT  - risk factors
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/29 06:00
MHDA- 2021/10/29 06:01
PMCR- 2021/01/01
CRDT- 2021/10/28 06:42
PHST- 2021/07/27 00:00 [received]
PHST- 2021/08/25 00:00 [accepted]
PHST- 2021/10/28 06:42 [entrez]
PHST- 2021/10/29 06:00 [pubmed]
PHST- 2021/10/29 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.748256 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Oct 11;8:748256. doi: 10.3389/fcvm.2021.748256. 
      eCollection 2021.