PMID- 34708623
OWN - NLM
STAT- MEDLINE
DCOM- 20220223
LR  - 20220223
IS  - 2589-451X (Electronic)
IS  - 0255-2922 (Linking)
VI  - 41
IP  - 5
DP  - 2021 Oct
TI  - Effectiveness and safety of traditional Chinese herbs in children with cough 
      variant asthma: a systematic review and Meta-analysi.
PG  - 661-668
LID - 10.19852/j.cnki.jtcm.2021.05.001 [doi]
AB  - OBJECTIVE: To systematically investigate the clinical effectiveness and safety of 
      traditional Chinese herbs (TCHs) as an alternative to conventional medicine (CM) 
      in children with cough variant asthma(CVA). METHODS: Randomized controlled trial 
      (RCT) studies that were published from their inceptions to March 31, 2020, were 
      identified from the electronic databases of China National Knowledge 
      Infrastructure, Wangfang, PubMed, and Cochrane Central Library. The primary 
      outcome of the review was the total effective rate (TER), and the secondary 
      outcomes were immunoglobulin E (IgE), peak expiratory flow (PEF), adverse drug 
      reactions, and relapse rates of interventions. RESULTS: For the Meta-analysis, 13 
      studies involving 992 children with CVA were included. In terms of TER and IgE, 
      the experimental interventions of TCH, when compared with the control 
      interventions of CM, on pediatric CVA were found to be significantly effective (P 
      < 0.0001), whereas for spirometry, PEF was not significantly improved in the TCH 
      group (P = 0.48). The incident rates of adverse drug reaction and relapse were 
      found to be significantly lower in the TCH group than those in the CM group (P = 
      0.02 and P < 0.0001, respectively). CONCLUSION: Compared with CM therapy, the 
      effects of TCH therapy on pediatric CVA were significantly beneficial in terms of 
      TER and IgE, but not for PEF, and the methodological quality of included studies 
      was poor. Therefore, the results should be interpreted with caution. More 
      randomized controlled trials with rigorous experimental methodologies are 
      required for objectivity in the future.
FAU - Kyou-Hwan, Han
AU  - Kyou-Hwan H
AD  - Department of data analysis, SBU Research Institute of Integrative Medicine, 
      South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA.
FAU - Ki Haeng, Cho
AU  - Ki Haeng C
AD  - Department of data analysis, SBU Research Institute of Integrative Medicine, 
      South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA.
FAU - Cui, Shan-Qin
AU  - Cui SQ
AD  - SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 
      6th Street, Los Angeles, CA 90057, USA.
FAU - Lily, Lin
AU  - Lily L
AD  - Department of Library, South Baylo University, 2727 West 6th Street, Los Angeles, 
      CA 90057, USA.
FAU - Jaejong, Kim
AU  - Jaejong K
AD  - Department of data analysis, SBU Research Institute of Integrative Medicine, 
      South Baylo University, 2727 West 6th Street, Los Angeles, CA 90057, USA.
LA  - eng
PT  - Meta-Analysis
PT  - Systematic Review
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - *Asthma/drug therapy
MH  - Child
MH  - China
MH  - Cough/drug therapy
MH  - *Drugs, Chinese Herbal/adverse effects
MH  - Humans
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Child
OT  - Cough variant asthma
OT  - Drugs, Chinese herbal
OT  - Meta-analysi
OT  - Randomized controlled trial
OT  - Systematic review
EDAT- 2021/10/29 06:00
MHDA- 2022/02/24 06:00
CRDT- 2021/10/28 07:04
PHST- 2021/10/28 07:04 [entrez]
PHST- 2021/10/29 06:00 [pubmed]
PHST- 2022/02/24 06:00 [medline]
AID - 10.19852/j.cnki.jtcm.2021.05.001 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2021 Oct;41(5):661-668. doi: 10.19852/j.cnki.jtcm.2021.05.001.