PMID- 34708772
OWN - NLM
STAT- MEDLINE
DCOM- 20211104
LR  - 20220427
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 69
IP  - 11
DP  - 2021 Nov
TI  - Elevated advanced glycation end products are associated with subfoveal ellipsoid 
      zone disruption in diabetic macular edema.
PG  - 3199-3202
LID - 10.4103/ijo.IJO_1244_21 [doi]
AB  - PURPOSE: Advanced glycation end products (AGEs), due to increased production and 
      a slow turnover rate, serve as mediators of "metabolic memory" even after the 
      resolution of hyperglycemia. A prospective study was undertaken to evaluate the 
      association of AGEs with subfoveal ellipsoid zone (EZ) disruption in diabetic 
      macular edema (DME). METHODS: A tertiary-care-center-based cross-sectional study 
      included 40 consecutive cases with DME and 20 healthy controls in the age group 
      of 40-65 years. All the study subjects underwent spectral-domain optical 
      coherence tomography (SD-OCT) for cross-sectional imaging of the retina. The EZ 
      was defined as a hyperreflective band below the external limiting membrane. The 
      disruption of EZ was graded as intact EZ and disrupted EZ. Serum AGEs were 
      assessed by assay of N(epsilon)-carboxymethyl-lysine (N(epsilon)-CML) using the standard 
      protocol. Data were analyzed statistically. RESULTS: Subfoveal EZ disruption was 
      noted in 80% (32/40) of the cases of DME. In the cases without EZ disruption, 
      visual acuity (LogMAR VA) was 0.60 +/- 0.52, whereas in cases with EZ disruption, 
      LogMAR VA was 0.96 +/- 0.56 (P < 0.001). In the cases without EZ disruption, 
      N(epsilon)-CML was 94.31 +/- 57 ng/mL, whereas in cases with EZ disruption N(epsilon)-CML was 
      120.64 +/- 71.98 ng/mL (P < 0.001). CONCLUSION: In DME, increased levels of AGEs 
      are significantly associated with EZ disruption on SD-OCT.
FAU - Mishra, Nibha
AU  - Mishra N
AD  - Department of Ophthalmology, King George's Medical University, Lucknow, Uttar 
      Pradesh, India.
FAU - Singh, Malvika
AU  - Singh M
AD  - Department of Ophthalmology, King George's Medical University, Lucknow, Uttar 
      Pradesh, India.
FAU - Singh, Rajendra K
AU  - Singh RK
AD  - CSIR-Indian Institute of Toxicological Research, Lucknow and Department of 
      Biochemistry, State Medical College Bahraich, Uttar Pradesh, India.
FAU - Saxena, Sandeep
AU  - Saxena S
AD  - Department of Ophthalmology, King George's Medical University, Lucknow, Uttar 
      Pradesh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
RN  - 0 (Glycation End Products, Advanced)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus
MH  - *Diabetic Retinopathy/complications/diagnosis
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - *Macular Edema/diagnosis/etiology
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
PMC - PMC8725141
OTO - NOTNLM
OT  - Advanced glycation end products
OT  - EZ
OT  - diabetic macular edema
OT  - diabetic retinopathy
OT  - spectral-domain optical coherence tomography
COIS- None
EDAT- 2021/10/29 06:00
MHDA- 2021/11/05 06:00
PMCR- 2021/11/01
CRDT- 2021/10/28 08:39
PHST- 2021/10/28 08:39 [entrez]
PHST- 2021/10/29 06:00 [pubmed]
PHST- 2021/11/05 06:00 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2021_69_11_3199_329223 [pii]
AID - IJO-69-3199 [pii]
AID - 10.4103/ijo.IJO_1244_21 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2021 Nov;69(11):3199-3202. doi: 10.4103/ijo.IJO_1244_21.