PMID- 34710241
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20220214
IS  - 1096-8652 (Electronic)
IS  - 0361-8609 (Linking)
VI  - 97
IP  - 1
DP  - 2022 Jan 1
TI  - Prognostic significance of acquired 1q22 gain in multiple myeloma.
PG  - 52-59
LID - 10.1002/ajh.26391 [doi]
AB  - Gain of 1q22 at diagnosis portends poorer outcomes in multiple myeloma (MM), but 
      the prognostic significance of acquired 1q22 gain is unknown. We identified 63 MM 
      patients seen at Mayo Clinic from 1/2004 to 12/2019 without 1q22 gain at 
      diagnosis who acquired it during follow up and compared them to 63 control 
      patients who did not acquire 1q22 gain with similar follow up. We also compared 
      outcomes in the acquired 1q22 gain group with outcomes in 126 patients with 1q22 
      gain present at diagnosis. The incidence of acquired 1q22 gain was 6.1% (median 
      follow-up 6.8 years); median time to acquisition was 5.0 years (range: 
      0.7-11.5 years). Abnormalities on baseline fluorescence in situ hybridization 
      (FISH) included trisomies (54%) and monosomy 13 (39%); 16 (25%) had high-risk 
      (HR) translocations or del(17p). Median progression-free survival with front line 
      therapy was 29.5 months in patients with acquired 1q22 gain, versus 31.4 months 
      in control patients (p = .34) and 31.2 months in patients with de novo 1q22 gain 
      (p = .04). Median overall survival (OS) from diagnosis was 10.9 years in patients 
      with acquired 1q22 gain, versus 13.0 years in control patients (p = .03) and 
      6.3 years in patients with de novo 1q22 gain (p = .01). Presence of HR FISH at 
      baseline increased risk of 1q22 gain acquisition. We demonstrate that acquisition 
      of 1q22 gain is a significant molecular event in MM, associated with reduced OS. 
      Among HR patients for whom this clonal evolution is determined, a risk-adapted 
      approach and/or clinical trial should be considered.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Audil, Hadiyah Y
AU  - Audil HY
AUID- ORCID: 0000-0002-0459-6521
AD  - Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Cook, Joselle M
AU  - Cook JM
AUID- ORCID: 0000-0001-5335-9533
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Greipp, Patricia T
AU  - Greipp PT
AUID- ORCID: 0000-0002-5536-9011
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 
      Minnesota, USA.
FAU - Kapoor, Prashant
AU  - Kapoor P
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Baughn, Linda B
AU  - Baughn LB
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 
      Minnesota, USA.
FAU - Dispenzieri, Angela
AU  - Dispenzieri A
AUID- ORCID: 0000-0001-8780-9512
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Gertz, Morie A
AU  - Gertz MA
AUID- ORCID: 0000-0002-3853-5196
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Buadi, Francis K
AU  - Buadi FK
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Lacy, Martha Q
AU  - Lacy MQ
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Dingli, David
AU  - Dingli D
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Fonder, Amie L
AU  - Fonder AL
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Hayman, Suzanne R
AU  - Hayman SR
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Hobbs, Miriam A
AU  - Hobbs MA
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Muchtar, Eli
AU  - Muchtar E
AUID- ORCID: 0000-0003-2210-2174
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Siddiqui, Mustaqeem
AU  - Siddiqui M
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Gonsalves, Wilson I
AU  - Gonsalves WI
AUID- ORCID: 0000-0001-6890-969X
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Hwa, Yi Lisa
AU  - Hwa YL
AUID- ORCID: 0000-0002-8163-2979
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Leung, Nelson
AU  - Leung N
AUID- ORCID: 0000-0002-5651-1411
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Lin, Yi
AU  - Lin Y
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Kourelis, Taxiarchis V
AU  - Kourelis TV
AUID- ORCID: 0000-0001-8573-9434
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Warsame, Rahma
AU  - Warsame R
AUID- ORCID: 0000-0003-0240-0326
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Kyle, Robert A
AU  - Kyle RA
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Ketterling, Rhett P
AU  - Ketterling RP
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 
      Minnesota, USA.
FAU - Rajkumar, S Vincent
AU  - Rajkumar SV
AUID- ORCID: 0000-0002-5862-1833
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Kumar, Shaji K
AU  - Kumar SK
AUID- ORCID: 0000-0001-5392-9284
AD  - Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
LA  - eng
PT  - Journal Article
DEP - 20211103
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Aged
MH  - Chromosome Duplication
MH  - Chromosomes, Human, Pair 1
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Myeloma/diagnosis/*genetics
MH  - Prognosis
MH  - Survival Analysis
EDAT- 2021/10/29 06:00
MHDA- 2022/02/15 06:00
CRDT- 2021/10/28 17:29
PHST- 2021/10/22 00:00 [revised]
PHST- 2021/07/14 00:00 [received]
PHST- 2021/10/24 00:00 [accepted]
PHST- 2021/10/29 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
PHST- 2021/10/28 17:29 [entrez]
AID - 10.1002/ajh.26391 [doi]
PST - ppublish
SO  - Am J Hematol. 2022 Jan 1;97(1):52-59. doi: 10.1002/ajh.26391. Epub 2021 Nov 3.