PMID- 34710474
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 193
IP  - Pt A
DP  - 2021 Dec 15
TI  - Polysaccharide/mesoporous silica nanoparticle-based drug delivery systems: A 
      review.
PG  - 457-473
LID - S0141-8130(21)02299-6 [pii]
LID - 10.1016/j.ijbiomac.2021.10.142 [doi]
AB  - Mesoporous silica nanoparticles (MSNs) have been well-researched in the design 
      and fabrication of advanced drug delivery systems (DDSs) due to their advantages 
      such as good biocompatibility, large specific surface area and pore volume for 
      drug loading, easily surface modification, adjusted size and good 
      thermal/chemical stability. For MSN-based DDSs, gate materials are also 
      necessary. And natural polysaccharides, one kind of the most abundant natural 
      resource, have been widely applied as the "gatekeepers" in MSN-based DDSs. 
      Polysaccharides are cheap and rich in sources with good biocompatibility, and 
      some of them have important biological functions. In this review article, 
      polysaccharides including chitosan, hyaluronic acid, sodium alginate and dextran, 
      et al. are briefly introduced. And the preparation processes and properties such 
      as controlled drug release, cancer targeting and disease diagnosis of functional 
      polysaccharide/MSN-based DDSs are discussed.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Kuang, Ying
AU  - Kuang Y
AD  - Glyn O. Philips Hydrocolloid Research Centre at HUT, Hubei University of 
      Technology, Wuhan, Hubei 430068, China.
FAU - Zhai, Junjun
AU  - Zhai J
AD  - Glyn O. Philips Hydrocolloid Research Centre at HUT, Hubei University of 
      Technology, Wuhan, Hubei 430068, China.
FAU - Xiao, Qinjian
AU  - Xiao Q
AD  - Glyn O. Philips Hydrocolloid Research Centre at HUT, Hubei University of 
      Technology, Wuhan, Hubei 430068, China.
FAU - Zhao, Si
AU  - Zhao S
AD  - Glyn O. Philips Hydrocolloid Research Centre at HUT, Hubei University of 
      Technology, Wuhan, Hubei 430068, China.
FAU - Li, Cao
AU  - Li C
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China. Electronic address: licao0415@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211025
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 0 (Polysaccharides)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Delayed-Action Preparations
MH  - Drug Carriers/*pharmacology
MH  - Humans
MH  - Nanoparticles/*chemistry
MH  - Neoplasms/*drug therapy
MH  - Polysaccharides/*pharmacology
MH  - Silicon Dioxide/*pharmacology
OTO - NOTNLM
OT  - Drug delivery system
OT  - Mesoporous silica nanoparticle
OT  - Polysaccharide
EDAT- 2021/10/29 06:00
MHDA- 2021/12/21 06:00
CRDT- 2021/10/28 20:14
PHST- 2021/08/20 00:00 [received]
PHST- 2021/09/30 00:00 [revised]
PHST- 2021/10/19 00:00 [accepted]
PHST- 2021/10/29 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2021/10/28 20:14 [entrez]
AID - S0141-8130(21)02299-6 [pii]
AID - 10.1016/j.ijbiomac.2021.10.142 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2021 Dec 15;193(Pt A):457-473. doi: 
      10.1016/j.ijbiomac.2021.10.142. Epub 2021 Oct 25.