PMID- 34711163
OWN - NLM
STAT- MEDLINE
DCOM- 20220617
LR  - 20220816
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
VI  - 22
IP  - 8
DP  - 2022
TI  - Does the Interaction of KIR and HLA Affect the Development of Non-Infectious 
      Uveitis?
PG  - 703-716
LID - 10.2174/1566524021666211027092124 [doi]
AB  - Immune tolerance is established in the eye to prevent permanent blindness 
      associated with destructive damage to the cornea and retina caused by immune cell 
      infiltration; hence, the immune responses and subsequent inflammations are 
      strongly suppressed. While non-infectious uveitis develops from a disruption of 
      immune tolerance in the eye, its onset is a result of accumulating etiologic 
      factors, including genetic predisposition, environmental factors, and aging. Many 
      non-infectious uveitis cases are genetically predisposed to human leukocyte 
      antigen (HLA) as the most substantial disease susceptibility region. HLA class I 
      molecules are critical for natural killer (NK) cells to distinguish between self 
      and non-self. The killer cell Ig-like receptor (KIR) family is one of the 
      essential components of these receptors. Evidence has accumulated that NK cells 
      are involved in innate and acquired immunity by interacting with other 
      immunocompetent cells to develop several autoimmune diseases. This review 
      summarizes the possible role of KIR in the development of non-infectious uveitis.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Nakamura, Jutaro
AU  - Nakamura J
AD  - Department of Ophthalmology and Visual Science, Yokohama City University Graduate 
      School of Medicine, Yokohama, Japan.
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Takeuchi, Masaki
AU  - Takeuchi M
AD  - Department of Ophthalmology and Visual Science, Yokohama City University Graduate 
      School of Medicine, Yokohama, Japan.
FAU - Ota, Masao
AU  - Ota M
AD  - Department of Ophthalmology and Visual Science, Yokohama City University Graduate 
      School of Medicine, Yokohama, Japan.
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, Matsumoto, Japan.
FAU - Mizuki, Nobuhisa
AU  - Mizuki N
AD  - Department of Ophthalmology and Visual Science, Yokohama City University Graduate 
      School of Medicine, Yokohama, Japan.
FAU - Ohno, Shigeaki
AU  - Ohno S
AD  - Department of Ophthalmology and Visual Science, Yokohama City University Graduate 
      School of Medicine, Yokohama, Japan.
AD  - Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, 
      Hokkaido University, Sapporo, Hokkaido, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Killer Cells, Natural
MH  - *Receptors, KIR/genetics
MH  - *Uveitis/genetics
OTO - NOTNLM
OT  - Behcet's disease
OT  - NK cell
OT  - Vogt- Koyanagi-Harada disease
OT  - acute anterior uveitis
OT  - birdshot chorioretinopathy
OT  - human leukocyte antigen
OT  - immune privilege site
OT  - killer cell Ig-like receptor
OT  - uveitis
EDAT- 2021/10/30 06:00
MHDA- 2022/06/18 06:00
CRDT- 2021/10/29 05:29
PHST- 2021/02/19 00:00 [received]
PHST- 2021/07/06 00:00 [revised]
PHST- 2021/08/26 00:00 [accepted]
PHST- 2021/10/30 06:00 [pubmed]
PHST- 2022/06/18 06:00 [medline]
PHST- 2021/10/29 05:29 [entrez]
AID - CMM-EPUB-118572 [pii]
AID - 10.2174/1566524021666211027092124 [doi]
PST - ppublish
SO  - Curr Mol Med. 2022;22(8):703-716. doi: 10.2174/1566524021666211027092124.