PMID- 34712121
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211030
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 15
DP  - 2021
TI  - Emerging Roles of Microglia in Neuro-vascular Unit: Implications of 
      Microglia-Neurons Interactions.
PG  - 706025
LID - 10.3389/fncel.2021.706025 [doi]
LID - 706025
AB  - Microglia, which serve as the defensive interface of the nervous system, are 
      activated in many neurological diseases. Their role as immune responding cells 
      has been extensively studied in the past few years. Recent studies have 
      demonstrated that neuronal feedback can be shaped by the molecular signals 
      received and sent by microglia. Altered neuronal activity or synaptic plasticity 
      leads to the release of various communication messages from neurons, which in 
      turn exert effects on microglia. Research on microglia-neuron communication has 
      thus expanded from focusing only on neurons to the neurovascular unit (NVU). This 
      approach can be used to explore the potential mechanism of neurovascular coupling 
      across sophisticated receptor systems and signaling cascades in health and 
      disease. However, it remains unclear how microglia-neuron communication happens 
      in the brain. Here, we discuss the functional contribution of microglia to 
      synapses, neuroimmune communication, and neuronal activity. Moreover, the current 
      state of knowledge of bidirectional control mechanisms regarding interactions 
      between neurons and microglia are reviewed, with a focus on purinergic regulatory 
      systems including ATP-P(2)RY(12)R signaling, ATP-adenosine-A(1)Rs/A(2A)Rs, and 
      the ATP-pannexin 1 hemichannel. This review aims to organize recent studies to 
      highlight the multifunctional roles of microglia within the neural communication 
      network in health and disease.
CI  - Copyright (c) 2021 Ding, Guo, Luo, Zheng, Gan, Kang, Wu and Zhu.
FAU - Ding, Zhe
AU  - Ding Z
AD  - Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Guo, Shaohui
AU  - Guo S
AD  - Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Luo, Lihui
AU  - Luo L
AD  - Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Zheng, Yueying
AU  - Zheng Y
AD  - Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Gan, Shuyuan
AU  - Gan S
AD  - Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Kang, Xianhui
AU  - Kang X
AD  - Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Wu, Xiaomin
AU  - Wu X
AD  - Department of Anesthesiology, Zhejiang Provincial People's Hospital, People's 
      Hospital of Hangzhou Medical College, Hangzhou, China.
FAU - Zhu, Shengmei
AU  - Zhu S
AD  - Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20211012
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC8546170
OTO - NOTNLM
OT  - ATP
OT  - NVU
OT  - microglia
OT  - microglia-neurons communication
OT  - neuronal activity
OT  - synaptic plasticity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/30 06:00
MHDA- 2021/10/30 06:01
PMCR- 2021/01/01
CRDT- 2021/10/29 06:24
PHST- 2021/05/06 00:00 [received]
PHST- 2021/09/10 00:00 [accepted]
PHST- 2021/10/29 06:24 [entrez]
PHST- 2021/10/30 06:00 [pubmed]
PHST- 2021/10/30 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2021.706025 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2021 Oct 12;15:706025. doi: 10.3389/fncel.2021.706025. 
      eCollection 2021.