PMID- 34712820
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2391-5412 (Electronic)
IS  - 2391-5412 (Linking)
VI  - 16
IP  - 1
DP  - 2021
TI  - Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast 
      cancer in Burkina Faso.
PG  - 1101-1110
LID - 10.1515/biol-2021-0113 [doi]
AB  - Several factors contribute to the development of breast cancer, including the 
      immune system. This study is aimed to characterize the carriage of human 
      leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. 
      This case-control study consisted of 96 histologically diagnosed breast cancer 
      cases and 102 controls (cases without breast abnormalities). A multiplex 
      polymerase chain reaction (PCR) was used to characterize the carriage of 
      HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of 
      cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of 
      cases and 55.88% of controls. This study found no direct association between the 
      carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast 
      cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated 
      (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01-1.14]; and p 
      = 0.03) which is a risk for breast cancer. No direct association was found 
      between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. 
      However, further investigation of other HLA alleles involved in the occurrence of 
      breast cancer may provide more information.
CI  - (c) 2021 Abdou Azaque Zoure et al., published by De Gruyter.
FAU - Zoure, Abdou Azaque
AU  - Zoure AA
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
AD  - Department of Biomedical and Public Health/Institute of Health Sciences Research, 
      (IRSS/CNRST), Institute of Health Sciences Research, 03 BP 7192, Ouagadougou 03, 
      Burkina Faso.
FAU - Amegnona, Lanyo Jospin
AU  - Amegnona LJ
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
FAU - Zongo, Nayi
AU  - Zongo N
AD  - Department of Surgery and Surgical Specialties, Service of General and Digestive 
      Surgery, University Hospital Centre-Yalgado OUEDRAOGO, UFR/SDS, University Joseph 
      KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso.
FAU - Kiendrebeogo, Isabelle Touwendpoulimde
AU  - Kiendrebeogo IT
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Sorgho, Pegdwende Abel
AU  - Sorgho PA
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Zongo, Fabienne Ingrid
AU  - Zongo FI
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Yonli, Albert Theophane
AU  - Yonli AT
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Sombie, Herman Karim
AU  - Sombie HK
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Bambara, Aboubacar Hierrhum
AU  - Bambara AH
AD  - Department of Medicine and Medical Specialties, Service of Oncology, University 
      Hospital Centre-BOGODOGO, University Joseph KI-ZERBO, UFR/SDS, 03 BP 7021, 
      Ouagadougou 03, Burkina Faso.
FAU - Sawadogo, Alexis Yobi
AU  - Sawadogo AY
AD  - Department of Gynecology-Obstetrics, Service of Gynecology, University Hospital 
      Centre-BOGODOGO, University Joseph KI ZERBO, UFR/SDS, 03 BP 7021, Ouagadougou 03, 
      Burkina Faso.
FAU - Ouedraogo, Marie N L
AU  - Ouedraogo MNL
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
AD  - Faculty of Medicine, University Saint Thomas d'Aquin, 06 BP 10212, Ouagadougou 
      01, Burkina Faso.
FAU - Traore, Lassina
AU  - Traore L
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Zongo, Sidnooma Veronique
AU  - Zongo SV
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Lallogo, Doriane Tatiana
AU  - Lallogo DT
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Bazie, Bapio Valery Jean Telesphore Elvira
AU  - Bazie BVJTE
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Zohoncon, Theodora M
AU  - Zohoncon TM
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
AD  - Faculty of Medicine, University Saint Thomas d'Aquin, 06 BP 10212, Ouagadougou 
      01, Burkina Faso.
FAU - Dijgma, Florencia W
AU  - Dijgma FW
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
FAU - Simpore, Jacques
AU  - Simpore J
AD  - Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and 
      Genetics (LABIOGENE), UFR/SVT, University Joseph KI-ZERBO, 03 P.O. Box 7021, 
      Ouagadougou 03, Burkina Faso.
AD  - Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center 
      (CERBA), 01 P.O. Box 364, Ouagadougou 01, Burkina Faso.
LA  - eng
PT  - Journal Article
DEP - 20211011
PL  - Poland
TA  - Open Life Sci
JT  - Open life sciences
JID - 101669614
PMC - PMC8511965
OTO - NOTNLM
OT  - Burkina Faso
OT  - HLA-DRB1*11
OT  - HLA-DRB1*12
OT  - breast cancer
OT  - risk factors
COIS- Conflict of interest: The authors state no conflict of interest.
EDAT- 2021/10/30 06:00
MHDA- 2021/10/30 06:01
PMCR- 2021/10/11
CRDT- 2021/10/29 06:32
PHST- 2021/05/25 00:00 [received]
PHST- 2021/07/28 00:00 [revised]
PHST- 2021/08/16 00:00 [accepted]
PHST- 2021/10/29 06:32 [entrez]
PHST- 2021/10/30 06:00 [pubmed]
PHST- 2021/10/30 06:01 [medline]
PHST- 2021/10/11 00:00 [pmc-release]
AID - biol-2021-0113 [pii]
AID - 10.1515/biol-2021-0113 [doi]
PST - epublish
SO  - Open Life Sci. 2021 Oct 11;16(1):1101-1110. doi: 10.1515/biol-2021-0113. 
      eCollection 2021.