PMID- 34713690
OWN - NLM
STAT- MEDLINE
DCOM- 20220524
LR  - 20220524
IS  - 2354-4716 (Electronic)
IS  - 0172-780X (Linking)
VI  - 42
IP  - 6
DP  - 2021 Oct
TI  - Long-term follow-up of a case of MEN1 and literature review.
PG  - 369-374
AB  - OBJECTIVE: To investigate the diagnosis and treatment of Multiple Endocrine 
      Neoplasia Type 1 (MEN1), improve our understanding of the disease and highlight 
      the importance of life-long follow-up of affected individuals. METHODS: A 
      retrospective analysis was performed on 1 MEN1 patient with long-term follow-up 
      at the First Affiliated Hospital of Anhui Medical University. RESULTS: A 
      51-year-old woman was diagnosed with MEN1 14 years ago, but exhibited a suspected 
      disease course of at least 20 years. Prior to admission, the patient reported a 
      cough lasting for two months. The patient's thyroid hormone, sex hormone, 
      insulin, cortisol, parathyroid hormone, and ACTH circadian rhythm findings were 
      within normal ranges. The patient exhibited elevated blood calcium levels. 
      Examination led to the detection of thymoma and pancreatic neoplasms, whereas no 
      obvious abnormalities were detected in her parathyroid gland or adrenal gland as 
      determined via computed tomography (CT). Genetic analyses revealed a mutation in 
      the MEN1 gene in this patient. As the patient had no relevant clinical symptoms, 
      she refused surgical treatment, and follow-up was continued. It was learned 
      through follow-up that the patient underwent anterior mediastinal lesion 
      resection and partial rib resection in June 2020 because she re-examined the 
      chest CT showed that the anterior mediastinal mass was significantly larger than 
      that in 2019. Pathology suggested neuroendocrine tumors. The patient is currently 
      recovering well. CONCLUSION: MEN1 is an uncommon condition in clinical settings, 
      and it is important that clinicians be made aware of this disorder so that they 
      can provide patients with appropriate and timely treatments.
FAU - Xu, Qian
AU  - Xu Q
AD  - Department of Endocrinology, Institute of Endocrinology and Metabolism, The First 
      Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
FAU - Hui, Cancan
AU  - Hui C
AD  - Department of Endocrinology, Anhui Geriatric Institute, The First Affiliated 
      Hospital of Anhui Medical University, Hefei 230022, China.
FAU - Hou, Lele
AU  - Hou L
AD  - Department of Endocrinology, Institute of Endocrinology and Metabolism, The First 
      Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
FAU - Zheng, Pingping
AU  - Zheng P
AD  - Department of Endocrinology, Institute of Endocrinology and Metabolism, The First 
      Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
FAU - Lu, Yating
AU  - Lu Y
AD  - Department of Endocrinology, Institute of Endocrinology and Metabolism, The First 
      Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
FAU - Deng, Datong
AU  - Deng D
AD  - Department of Endocrinology, Institute of Endocrinology and Metabolism, The First 
      Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
SB  - IM
MH  - Adrenal Glands
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - *Multiple Endocrine Neoplasia Type 1/diagnosis/genetics/surgery
MH  - *Pancreatic Neoplasms/diagnosis
MH  - Retrospective Studies
EDAT- 2021/10/30 06:00
MHDA- 2022/05/25 06:00
CRDT- 2021/10/29 07:57
PHST- 2021/03/09 00:00 [received]
PHST- 2021/09/04 00:00 [accepted]
PHST- 2021/10/30 06:00 [pubmed]
PHST- 2022/05/25 06:00 [medline]
PHST- 2021/10/29 07:57 [entrez]
AID - NEL420621C12 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2021 Oct;42(6):369-374.