PMID- 34714280
OWN - NLM
STAT- MEDLINE
DCOM- 20220321
LR  - 20230822
IS  - 1536-4828 (Electronic)
IS  - 0885-3177 (Linking)
VI  - 50
IP  - 8
DP  - 2021 Sep 1
TI  - Pancreatic Neuroendocrine Neoplasias in Multiple Endocrine Neoplasia Type 1 Are 
      Predominantly Located in the Dorsal Anlage: An Endoscopic Ultrasound Study.
PG  - 1169-1172
LID - 10.1097/MPA.0000000000001890 [doi]
AB  - OBJECTIVES: Pancreatic neuroendocrine neoplasias (pNENs) frequently occur in 
      multiple endocrine neoplasia type 1 (MEN1). Their distribution referring to 
      embryology, that is, the pancreatic anlagen, has not been investigated yet. 
      METHODS: In the time between 1998 and 2019, we studied the distribution of pNENs 
      in MEN1 concerning the embryologic origin of the pancreas, that is, the dorsal 
      versus ventral anlage using endoscopic ultrasound in 117 MEN1 patients: 56 women, 
      61 men; aged 40 years (standard deviation, 14 years) at first endoscopic 
      ultrasound. RESULTS: In 105 patients, a total of 628 pNENs were detected. They 
      were located in the pancreatic tail: 231; pancreatic body: 177; pancreatic 
      head/uncinate process: 220. Of the latter, 22 were located in the ventral anlage, 
      176 in the dorsal anlage, and 22 remained undefined. In summary, just 3.5% of all 
      detected pNENs were located in the ventral anlage, 93.0% in the dorsal anlage, 
      and 3.5% could not be assigned. CONCLUSIONS: Our study indicates that the vast 
      majority of pNENs in MEN1 is located in the dorsal anlage, whereas the ventral 
      anlage of the pancreas seems to be to a large extend spared from pNENs. 
      Implications for new surgical strategies might be considered.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Kann, Peter Herbert
AU  - Kann PH
FAU - Scheunemann, Adrian
AU  - Scheunemann A
AD  - From the Centre for Endocrinology, Diabetology & Osteology, Endocrine Laboratory, 
      Philipp's University and University Hospital, Marburg.
FAU - Dorzweiler, Peter
AU  - Dorzweiler P
AD  - From the Centre for Endocrinology, Diabetology & Osteology, Endocrine Laboratory, 
      Philipp's University and University Hospital, Marburg.
FAU - Adelmeyer, Jan
AU  - Adelmeyer J
AD  - From the Centre for Endocrinology, Diabetology & Osteology, Endocrine Laboratory, 
      Philipp's University and University Hospital, Marburg.
FAU - Bergmann, Simona
AU  - Bergmann S
AD  - From the Centre for Endocrinology, Diabetology & Osteology, Endocrine Laboratory, 
      Philipp's University and University Hospital, Marburg.
FAU - Goebel, Joachim Nils
AU  - Goebel JN
AD  - From the Centre for Endocrinology, Diabetology & Osteology, Endocrine Laboratory, 
      Philipp's University and University Hospital, Marburg.
FAU - Mann, Verena
AU  - Mann V
AD  - From the Centre for Endocrinology, Diabetology & Osteology, Endocrine Laboratory, 
      Philipp's University and University Hospital, Marburg.
FAU - Bartsch, Detlef K
AU  - Bartsch DK
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and 
      University Hospital, Marburg, Germany.
FAU - Holzer, Katharina
AU  - Holzer K
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and 
      University Hospital, Marburg, Germany.
FAU - Albers, Max B
AU  - Albers MB
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and 
      University Hospital, Marburg, Germany.
FAU - Manoharan, Jerena
AU  - Manoharan J
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and 
      University Hospital, Marburg, Germany.
FAU - Scheunemann, Lisann M
AU  - Scheunemann LM
AD  - From the Centre for Endocrinology, Diabetology & Osteology, Endocrine Laboratory, 
      Philipp's University and University Hospital, Marburg.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - *Endosonography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Neuroendocrine Tumors/*diagnostic imaging
MH  - Pancreatic Neoplasms/*diagnostic imaging
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/30 06:00
MHDA- 2022/03/22 06:00
CRDT- 2021/10/29 12:22
PHST- 2021/10/29 12:22 [entrez]
PHST- 2021/10/30 06:00 [pubmed]
PHST- 2022/03/22 06:00 [medline]
AID - 00006676-202109000-00006 [pii]
AID - 10.1097/MPA.0000000000001890 [doi]
PST - ppublish
SO  - Pancreas. 2021 Sep 1;50(8):1169-1172. doi: 10.1097/MPA.0000000000001890.