PMID- 34715440
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20220307
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 305
DP  - 2021 Nov
TI  - Changes in the cognitive function of Chinese college students with a clinical 
      high risk of psychosis.
PG  - 114242
LID - S0165-1781(21)00537-0 [pii]
LID - 10.1016/j.psychres.2021.114242 [doi]
AB  - The purpose of our study was to explore the value of measuring cognitive 
      functions for predicting the conversion to psychosis in Chinese college students 
      with a clinical high risk (CHR). A total of 115 CHR students and 99 healthy 
      controls were enrolled. All included participants were recruited from colleges in 
      Wuhan, China. The MATRICS Consensus Cognitive Battery was used to evaluate 
      cognitive function. CHR individuals were followed for 2 years, and the cognitive 
      function of CHR individuals who later converted to psychosis (CHR-C) was compared 
      to CHR individuals who did not convert (CHR-NC). Of the 107 CHR individuals that 
      completed the 2- year follow-up, 29 (27.1%) developed a psychotic disorder. CHR 
      individuals demonstrated poorer performance on all cognitive function tests 
      compared to controls. CHR-C participants exhibited poorer performance on all 
      cognitive tests except the Trail Making Test A and Continuous Performance 
      Test-Identical Pairs compared to CHR-NC participants. The most significant 
      differences displayed between CHR-C and CHR-NC groups were in visual learning, 
      working memory, and reasoning and problem solving. The degree of cognitive 
      impairment in visual learning and working memory may be a predictive marker for 
      individuals who are at risk of developing psychosis.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Luo, Xiaoyu
AU  - Luo X
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      whu_xyluo@163.com.
FAU - Zhang, Liguo
AU  - Zhang L
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      407591583@qq.com.
FAU - Zhang, Jianya
AU  - Zhang J
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      498264682@qq.com.
FAU - Chen, Hanhua
AU  - Chen H
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      386820342@qq.com.
FAU - Hong, Hanlin
AU  - Hong H
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      752048955@qq.com.
FAU - Luo, Ruqin
AU  - Luo R
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      645371534@qq.com.
FAU - Ma, Luyao
AU  - Ma L
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      381805550@qq.com.
FAU - Wang, Changwang
AU  - Wang C
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      3168014411@qq.com.
FAU - Jin, Fenshu
AU  - Jin F
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China.
FAU - Wang, Enfu
AU  - Wang E
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      231761647@qq.com.
FAU - Jiang, Zhendong
AU  - Jiang Z
AD  - Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of 
      Science and Technology, Wuhan 430000, China. Electronic address: 
      920445666@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211011
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - China
MH  - Cognition
MH  - Disease Progression
MH  - Humans
MH  - *Prodromal Symptoms
MH  - *Psychotic Disorders/psychology
MH  - Students
OTO - NOTNLM
OT  - Clinical high risk
OT  - Cognitive function
OT  - Conversion rates
OT  - Prodromal psychosis
EDAT- 2021/10/30 06:00
MHDA- 2022/03/08 06:00
CRDT- 2021/10/29 20:19
PHST- 2020/03/26 00:00 [received]
PHST- 2021/09/15 00:00 [revised]
PHST- 2021/10/10 00:00 [accepted]
PHST- 2021/10/30 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2021/10/29 20:19 [entrez]
AID - S0165-1781(21)00537-0 [pii]
AID - 10.1016/j.psychres.2021.114242 [doi]
PST - ppublish
SO  - Psychiatry Res. 2021 Nov;305:114242. doi: 10.1016/j.psychres.2021.114242. Epub 
      2021 Oct 11.