PMID- 34716536
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220818
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 200
IP  - 9
DP  - 2022 Sep
TI  - Yeast Selenium Exerts an Antioxidant Effect by Regulating the Level of 
      Selenoprotein to Antagonize Cd-Induced Pyroptosis of Chicken Liver.
PG  - 4079-4088
LID - 10.1007/s12011-021-02984-9 [doi]
AB  - Cadmium (Cd) exposure can cause multiple organ damage in humans and animals by 
      causing oxidative stress. Organic selenium can antagonize the toxic damage of 
      heavy metals by exerting antioxidant effects. Oxidative stress can activate 
      NLRP3/Caspase1-dependent pyroptosis, but it is not clear whether yeast selenium 
      (Se Y) can antagonize Cd-induced pyroptosis in the chicken liver. In this 
      experiment, we studied the effects of CdCl(2) single, Se Y single, and combined 
      exposure on the pyroptosis of chicken liver. The results showed that Cd exposure 
      induced oxidative stress in the chicken liver, and the expression of Sepx1, SelU, 
      SelT, GPx1, GPx4, Dio1, Dio2, Dio3, TrxR1, TrxR2, TrxR3, SelH, SelI, SelO, SelK, 
      SelPb, Selpp, and Sel15 decreased. In addition, NLRP3 inflammasome complex 
      (NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein 
      containing (ASC), and pro-Caspase1), Cysteinyl aspartate specific proteinase 
      (Caspase1), Interleukin-beta (IL-1beta), and Interleukin-18 (IL-18) were upregulated. 
      The combined treatment of Se Y and Cd found that the antioxidant level and the 
      expression level of selenoprotein recovered to the Se group, and the liver 
      pyroptosis decreased. Principal component analysis and correlation analysis 
      screened out that selenoprotein O (SelO) is negatively correlated with 
      pyroptosis-related genes. In short, our data shows that Se Y exerts an 
      antioxidant effect by increasing the expression of selenoproteins and 
      antagonizing the pyroptosis of chicken liver induced by Cd. This study provides 
      new ideas for the field of heavy metal toxicology research. And the selected SelO 
      has an important reference significance for follow-up research.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Pengcheng, Xing
AU  - Pengcheng X
AUID- ORCID: 0000-0001-8432-021X
AD  - College of International Culture and Education, Northeast Agricultural 
      University, Harbin, 150030, People's Republic of China.
FAU - Xu, Shi
AU  - Xu S
AUID- ORCID: 0000-0002-6549-3331
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, People's Republic of China.
FAU - Wei, Cui
AU  - Wei C
AUID- ORCID: 0000-0002-2719-3215
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, People's Republic of China.
FAU - Xiaodan, Huang
AU  - Xiaodan H
AUID- ORCID: 0000-0003-4501-7642
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, 
      150030, People's Republic of China. hxd790125@neau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211030
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Antioxidants)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (RNA, Messenger)
RN  - 0 (Selenoproteins)
RN  - 00BH33GNGH (Cadmium)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism/pharmacology
MH  - Cadmium/metabolism/toxicity
MH  - Chickens/metabolism
MH  - Liver/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - Pyroptosis
MH  - RNA, Messenger/genetics
MH  - Saccharomyces cerevisiae/metabolism
MH  - *Selenium/metabolism/pharmacology
MH  - Selenoproteins/genetics
OTO - NOTNLM
OT  - Cadmium
OT  - Chicken liver
OT  - Pyroptosis
OT  - Selenoprotein
OT  - Yeast selenium
EDAT- 2021/10/31 06:00
MHDA- 2022/08/17 06:00
CRDT- 2021/10/30 06:06
PHST- 2021/08/23 00:00 [received]
PHST- 2021/10/19 00:00 [accepted]
PHST- 2021/10/31 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2021/10/30 06:06 [entrez]
AID - 10.1007/s12011-021-02984-9 [pii]
AID - 10.1007/s12011-021-02984-9 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2022 Sep;200(9):4079-4088. doi: 10.1007/s12011-021-02984-9. 
      Epub 2021 Oct 30.