PMID- 34717198
OWN - NLM
STAT- MEDLINE
DCOM- 20211214
LR  - 20211214
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 279
DP  - 2021 Dec
TI  - Intelligent photothermal dendritic cells restart the cancer immunity cycle 
      through enhanced immunogenic cell death.
PG  - 121228
LID - S0142-9612(21)00585-8 [pii]
LID - 10.1016/j.biomaterials.2021.121228 [doi]
AB  - Dendritic cells (DCs) play a pivotal role in initiating antigen-specific tumor 
      immunity. However, the abnormal function of DCs owing to the immunosuppressive 
      tumor microenvironment (TME) and the insufficient number of tumor infiltrating 
      DCs could promote immune tolerance and tumor immune escape. Thus, there is great 
      potential to employ DCs to induce efficient antitumor immunity. In this paper, we 
      developed intelligent DCs (iDCs), which consist of nanoparticles loaded with 
      photothermal agents (IR-797) and coated with a mature DC membrane. The DC cell 
      membrane on the surface of iDCs preserves the ability to present antigens and 
      prime T cells. The iDCs can also enter the lymph node and stimulate T cells. The 
      activated T cells reduced the expression of heat shock proteins (HSPs) in tumor 
      cells, rendering them more sensitive to heat stress. Subsequently, we used mild 
      photothermal therapy (42-45  degrees C) to induce immunogenic cell death and contribute 
      to a synergistic antitumor effect. iDCs as a refined and precise system in 
      combination with DC-based immunotherapy and thermal therapy can be stored 
      long-term and on a large scale, so they can be applied in many patients.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Sun, Zhihong
AU  - Sun Z
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China; Qindao University Medical College Affiliated Yantai 
      Yuhuangding Hospital, Yantai, 264000, PR China.
FAU - Deng, Guanjun
AU  - Deng G
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China.
FAU - Peng, Xinghua
AU  - Peng X
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China.
FAU - Xu, Xiuli
AU  - Xu X
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China.
FAU - Liu, Lanlan
AU  - Liu L
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China.
FAU - Peng, Jiaofeng
AU  - Peng J
AD  - Instrumental Analysis Center of Shenzhen University, Shenzhen University, 
      Shenzhen, 518055, China.
FAU - Ma, Yifan
AU  - Ma Y
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China; HRYZ Biotech Co., Shenzhen, 518057, PR China.
FAU - Zhang, Pengfei
AU  - Zhang P
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China.
FAU - Wen, Austin
AU  - Wen A
AD  - Pomona College, 333 N College Way, Claremont, CA, 91711, USA.
FAU - Wang, Yifan
AU  - Wang Y
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA.
FAU - Yang, Zhaogang
AU  - Yang Z
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA.
FAU - Gong, Ping
AU  - Gong P
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China; Department of Radiation Oncology, The University of 
      Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: 
      ping.gong@siat.ac.cn.
FAU - Jiang, Wen
AU  - Jiang W
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX, USA. Electronic address: wjiang4@mdanderson.org.
FAU - Cai, Lintao
AU  - Cai L
AD  - Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of 
      Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key 
      Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, 
      Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 
      Shenzhen, 518055, China. Electronic address: lt.cai@siat.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211026
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
SB  - IM
MH  - Dendritic Cells
MH  - Humans
MH  - *Immunogenic Cell Death
MH  - Immunotherapy
MH  - *Neoplasms/therapy
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Biomimetic theranostics
OT  - Intelligent DCs
OT  - Mature dendritic cells
OT  - Mild photothermal therapy
OT  - NIR
OT  - TME
EDAT- 2021/10/31 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/10/30 20:12
PHST- 2021/06/08 00:00 [received]
PHST- 2021/10/17 00:00 [revised]
PHST- 2021/10/22 00:00 [accepted]
PHST- 2021/10/31 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/10/30 20:12 [entrez]
AID - S0142-9612(21)00585-8 [pii]
AID - 10.1016/j.biomaterials.2021.121228 [doi]
PST - ppublish
SO  - Biomaterials. 2021 Dec;279:121228. doi: 10.1016/j.biomaterials.2021.121228. Epub 
      2021 Oct 26.