PMID- 34717997
OWN - NLM
STAT- MEDLINE
DCOM- 20220120
LR  - 20220120
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 811
DP  - 2022 Mar 10
TI  - Sex-specific associations of exposure to metal mixtures with telomere length 
      change: Results from an 8-year longitudinal study.
PG  - 151327
LID - S0048-9697(21)06405-6 [pii]
LID - 10.1016/j.scitotenv.2021.151327 [doi]
AB  - Studies on the relationships between exposure to metal mixtures and telomere 
      length (TL) are limited, particularly longitudinal studies. Few studies are 
      available on the potential sex-specific associations between metal exposures and 
      TL change. We examined blood metal concentrations and TL at baseline (August 
      2012) and follow-up (June 2020) among 316 participants in a ferro-manganese 
      refinery. The least absolute shrinkage and selection operator (LASSO) followed by 
      the generalized linear model (GLM) was applied to evaluate the associations 
      between multiple-metal exposures and TL change (TL in 2012 minus TL in 2020). 
      Bayesian kernel machine regression (BKMR) was applied to cope with metal mixtures 
      and evaluate their joint effects on TL change. Among men, three statistical 
      methods consistently showed rubidium was negatively associated with TL change (beta 
      [95% CI] = -2.755 [-5.119, -0.391] in the GLM) and dominated the negative overall 
      effects of 10 metal mixtures (magnesium, manganese, iron, cobalt, copper, zinc, 
      selenium, rubidium, cadmium, and lead) on TL change (posterior inclusion 
      probabilities = 0.816). Among women, the GLM (beta [95% CI] = 4.463 [0.943, 7.983]) 
      and LASSO (beta = 4.289) showed rubidium was positively associated with TL change. 
      Interestingly, no significant association was observed between exposure to metal 
      mixtures and TL change in overall participants (P > 0.05). Furthermore, 
      stratified analysis showed significant relationships between rubidium and TL 
      change in men (beta = -2.744), women (beta = 3.624), and current smokers (beta = -3.266) 
      (both P interaction <0.05). In summary, our findings underlined the steady and 
      negative association between rubidium and TL change among men with potential 
      sex-dependent heterogeneities. Further experimental studies are required to 
      expound the underlying mechanisms.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - He, Junxiu
AU  - He J
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning 530021, China.
FAU - Ge, Xiaoting
AU  - Ge X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning 530021, China; Department of Public 
      Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou 
      545006, Guangxi, China.
FAU - Cheng, Hong
AU  - Cheng H
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning 530021, China.
FAU - Bao, Yu
AU  - Bao Y
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning 530021, China.
FAU - Feng, Xiuming
AU  - Feng X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning 530021, China.
FAU - Zan, Gaohui
AU  - Zan G
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning 530021, China.
FAU - Wang, Fei
AU  - Wang F
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning 530021, China.
FAU - Zou, Yunfeng
AU  - Zou Y
AD  - Department of Toxicology, School of Public Health, Guangxi Medical University, 
      Nanning 530021, China; Guangxi Colleges and Universities Key Laboratory of 
      Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, 
      Nanning 530021, China.
FAU - Yang, Xiaobo
AU  - Yang X
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Guangxi Medical University, Nanning 530021, China; Guangxi Colleges and 
      Universities Key Laboratory of Prevention and Control of Highly Prevalent 
      Diseases, Guangxi Medical University, Nanning 530021, China; Department of Public 
      Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou 
      545006, Guangxi, China. Electronic address: yangx@gxmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211028
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Metals)
RN  - 00BH33GNGH (Cadmium)
SB  - IM
MH  - Bayes Theorem
MH  - *Cadmium
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Metals/toxicity
MH  - Telomere
OTO - NOTNLM
OT  - Interactions
OT  - Metal mixtures
OT  - Rubidium
OT  - Sex-specific
OT  - Telomere length change
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/11/01 06:00
MHDA- 2022/01/21 06:00
CRDT- 2021/10/31 20:46
PHST- 2021/09/01 00:00 [received]
PHST- 2021/10/22 00:00 [revised]
PHST- 2021/10/26 00:00 [accepted]
PHST- 2021/11/01 06:00 [pubmed]
PHST- 2022/01/21 06:00 [medline]
PHST- 2021/10/31 20:46 [entrez]
AID - S0048-9697(21)06405-6 [pii]
AID - 10.1016/j.scitotenv.2021.151327 [doi]
PST - ppublish
SO  - Sci Total Environ. 2022 Mar 10;811:151327. doi: 10.1016/j.scitotenv.2021.151327. 
      Epub 2021 Oct 28.