PMID- 34718153
OWN - NLM
STAT- MEDLINE
DCOM- 20220128
LR  - 20220128
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 72
DP  - 2021 Dec
TI  - The protective effect of mindfulness and compassion meditation practices on 
      ageing: Hypotheses, models and experimental implementation.
PG  - 101495
LID - S1568-1637(21)00242-7 [pii]
LID - 10.1016/j.arr.2021.101495 [doi]
AB  - Alzheimer's disease (AD) represents a major health and societal issue; there is 
      no treatment to date and the pathophysiological mechanisms underlying this 
      disease are not well understood. Yet, there is hope that AD risk factors and thus 
      the number of AD cases can be significantly reduced by prevention measures based 
      on lifestyle modifications as targeted by non-pharmacological preventive 
      interventions. So far, these interventions have rarely targeted the 
      psycho-affective risk factors related to depression, stress, anxiety, and feeling 
      of loneliness, which are all prevalent in ageing. This paper presents the 
      hypothesis that the regular practice of mindfulness meditation (MM) and 
      loving-kindness and compassion meditation (LKCM) in the ageing population 
      constitutes a lifestyle that is protective against AD. In this model, these 
      practices can promote cognition, mental health, and well-being by strengthening 
      attention control, metacognitive monitoring, emotion regulation and pro-social 
      capacities. Training these capacities could reduce the risk of AD by upregulating 
      beneficial age-related factors such as cognitive reserve, and down-regulating 
      detrimental age-related factors, such as stress, or depression. As an 
      illustration, we present the Medit-Ageing study (public name Silver Sante Study), 
      an on-going European project that assesses the impact and mechanisms of 
      non-pharmacological interventions including meditation, in the ageing population.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Lutz, Antoine
AU  - Lutz A
AD  - Lyon Neuroscience Research Center Inserm U1028, CNRS UMR5292, Lyon 1 University, 
      Lyon, France. Electronic address: antoine.lutz@inserm.fr.
FAU - Chetelat, Gael
AU  - Chetelat G
AD  - Inserm, Inserm UMR-S U1237, Universite de Caen-Normandie, GIP Cyceron, Caen, 
      France. Electronic address: chetelat@cyceron.fr.
FAU - Collette, Fabienne
AU  - Collette F
AD  - GIGA-CRC In Vivo Imaging, Universite de Liege, Liege, Belgium.
FAU - Klimecki, Olga M
AU  - Klimecki OM
AD  - Institute of Clinical Psychology and Psychotherapy, TU Dresden, Germany.
FAU - Marchant, Natalie L
AU  - Marchant NL
AD  - Division of Psychiatry, University College London, London, United Kingdom.
FAU - Gonneaud, Julie
AU  - Gonneaud J
AD  - Inserm, Inserm UMR-S U1237, Universite de Caen-Normandie, GIP Cyceron, Caen, 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211027
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Aging
MH  - Cognition
MH  - Empathy
MH  - Humans
MH  - *Meditation
MH  - *Mindfulness
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Anxiety
OT  - Cognition
OT  - Eudaimonic well-being
OT  - Medit-Ageing
OT  - Silver Sante Study
EDAT- 2021/11/01 06:00
MHDA- 2022/01/29 06:00
CRDT- 2021/10/31 20:50
PHST- 2021/03/16 00:00 [received]
PHST- 2021/09/09 00:00 [revised]
PHST- 2021/10/18 00:00 [accepted]
PHST- 2021/11/01 06:00 [pubmed]
PHST- 2022/01/29 06:00 [medline]
PHST- 2021/10/31 20:50 [entrez]
AID - S1568-1637(21)00242-7 [pii]
AID - 10.1016/j.arr.2021.101495 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2021 Dec;72:101495. doi: 10.1016/j.arr.2021.101495. Epub 2021 Oct 
      27.