PMID- 34719617
OWN - NLM
STAT- MEDLINE
DCOM- 20211102
LR  - 20211102
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 67
IP  - 5
DP  - 2021
TI  - Maslinic Acid Promotes Hypertrophy Induced by Functional Overload in Mouse 
      Skeletal Muscle.
PG  - 317-322
LID - 10.3177/jnsv.67.317 [doi]
AB  - Nutritional supplements are sometimes important for athletes to improve their 
      sports performance and maintain their condition. Maslinic acid (MA) is a type of 
      compound with a pentacyclic triterpene structure extracted from olives, and has a 
      strong anti-inflammatory effect and improves metabolic function. This study aimed 
      to investigate the effects of MA on muscle hypertrophy by functional overload 
      using an animal model. Mice plantaris muscles were overloaded by synergist 
      ablation surgery with/without MA and they were sampled at 4, 7, and 14 d after 
      the operation. We demonstrated that MA significantly increased plantaris' 
      cross-sectional area and activated the mechanistic target of rapamycin (mTOR) 
      signaling compared with the non-supplemented group (main effect of MA, p<0.05). 
      In addition, MA also significantly reduced catabolic proteins compared with the 
      non-supplemented group. MA supplementation increased muscle fiber size and 
      promoted muscle hypertrophy via mTOR signaling. Our results indicate that MA 
      supplementation may be useful for promoting hypertrophy of skeletal muscle.
FAU - Shirai, Takanaga
AU  - Shirai T
AD  - Graduate School of Comprehensive Human Sciences, University of Tsukuba.
AD  - Reserch Fellow in Japan Society for Promotion Science.
FAU - Uemichi, Kazuki
AU  - Uemichi K
AD  - Graduate School of Comprehensive Human Sciences, University of Tsukuba.
FAU - Kubota, Kakeru
AU  - Kubota K
AD  - School of Physical Education, Health and Sport Sciences, University of Tsukuba.
FAU - Yamauchi, Yuki
AU  - Yamauchi Y
AD  - Tsukuba Life Science Innovation Program (T-LSI), University of Tsukuba.
FAU - Takemasa, Tohru
AU  - Takemasa T
AD  - Faculty of Health and Sport Sciences, University of Tsukuba.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Triterpenes)
RN  - E233J88OHQ (maslinic acid)
SB  - IM
MH  - Animals
MH  - Hypertrophy
MH  - Mice
MH  - Muscle Fibers, Skeletal
MH  - Muscle, Skeletal
MH  - *Triterpenes/pharmacology
OTO - NOTNLM
OT  - functional overload
OT  - hypertrophy
OT  - mTOR signaling
OT  - maslinic acid
OT  - protein synthesis
EDAT- 2021/11/02 06:00
MHDA- 2021/11/03 06:00
CRDT- 2021/11/01 05:59
PHST- 2021/11/01 05:59 [entrez]
PHST- 2021/11/02 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
AID - 10.3177/jnsv.67.317 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2021;67(5):317-322. doi: 10.3177/jnsv.67.317.