PMID- 34721908
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211102
IS  - 2090-6447 (Print)
IS  - 2090-6455 (Electronic)
VI  - 2021
DP  - 2021
TI  - A Case of Buccal Clear Cell Carcinoma Caused by Rare Fusion Gene: EWSR1-CREM.
PG  - 5557247
LID - 10.1155/2021/5557247 [doi]
LID - 5557247
AB  - Clear cell carcinoma (CCC) is a rare entity in the salivary gland tumor. So far, 
      only 10 cases of primary CCC of the buccal mucosa have been reported. Here, we 
      first report an extremely rare case of buccal CCC with the EWSR1-CREM fusion 
      gene. The patient, a 69-year-old woman, presented with a painless mass in the 
      right buccal mucosa. The tumor, which had been present for about 10 years, 
      measured approximately 15 mm in diameter and was pedunculated, elastic hard, 
      smooth, and mobile. Histopathological examination revealed proliferating tumor 
      cells with vacuolated and clear cytoplasm partially surrounded by hyalinized 
      stroma. The tumor was not encapsulated, and no contact with the overlying 
      epithelium was evident. Duct-like structures were occasionally observed in the 
      tumor nests composed of clear cells. The tumor had invaded into surrounding 
      muscle and adipose tissues. Immunohistochemical examination revealed that the 
      clear cells were positive for epithelial cell markers, and myoepithelial markers 
      were negative. Fluorescence in situ hybridization (FISH), performed to search for 
      genetic abnormalities, demonstrated split positivity for EWSR1, and fusion with 
      CREM was confirmed. These findings suggested a diagnosis of CCC.
CI  - Copyright (c) 2021 Miyako Hoshino et al.
FAU - Hoshino, Miyako
AU  - Hoshino M
AUID- ORCID: 0000-0002-5628-8942
AD  - Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai 
      University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.
FAU - Inoue, Katsuyuki
AU  - Inoue K
AD  - Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and 
      Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 
      Sakado, Saitama 350-0283, Japan.
FAU - Kaneda, Tomohisa
AU  - Kaneda T
AD  - Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and 
      Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 
      Sakado, Saitama 350-0283, Japan.
FAU - Nishimura, Michiko
AU  - Nishimura M
AD  - Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai 
      University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.
FAU - Kusama, Kaoru
AU  - Kusama K
AD  - Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai 
      University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.
FAU - Sakashita, Hideaki
AU  - Sakashita H
AD  - Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and 
      Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, 
      Sakado, Saitama 350-0283, Japan.
FAU - Sato, Yukiko
AU  - Sato Y
AUID- ORCID: 0000-0003-4277-0161
AD  - Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 
      3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
AD  - Department of Pathology, Cancer Institute Hospital, Japanese Foundation for 
      Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
FAU - Takeuchi, Kengo
AU  - Takeuchi K
AD  - Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 
      3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
AD  - Department of Pathology, Cancer Institute Hospital, Japanese Foundation for 
      Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
AD  - Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation 
      for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
FAU - Nagao, Toshitaka
AU  - Nagao T
AD  - Department of Anatomic Pathology, Tokyo Medical University, 7-3-1 Hongo, 
      Bunkyo-ku, Tokyo 113-0033, Japan.
FAU - Kikuchi, Kentaro
AU  - Kikuchi K
AUID- ORCID: 0000-0001-7869-6595
AD  - Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai 
      University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.
LA  - eng
PT  - Case Reports
DEP - 20211020
PL  - Egypt
TA  - Case Rep Dent
JT  - Case reports in dentistry
JID - 101573242
PMC - PMC8550837
COIS- All authors have no conflicts of interest to declare.
EDAT- 2021/11/02 06:00
MHDA- 2021/11/02 06:01
PMCR- 2021/10/20
CRDT- 2021/11/01 09:19
PHST- 2021/02/01 00:00 [received]
PHST- 2021/06/23 00:00 [revised]
PHST- 2021/10/08 00:00 [accepted]
PHST- 2021/11/01 09:19 [entrez]
PHST- 2021/11/02 06:00 [pubmed]
PHST- 2021/11/02 06:01 [medline]
PHST- 2021/10/20 00:00 [pmc-release]
AID - 10.1155/2021/5557247 [doi]
PST - epublish
SO  - Case Rep Dent. 2021 Oct 20;2021:5557247. doi: 10.1155/2021/5557247. eCollection 
      2021.