PMID- 34722773
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20221207
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2021
DP  - 2021
TI  - Association between Neutrophil Gelatinase-Associated Lipocalin and Fetal 
      Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus.
PG  - 8383875
LID - 10.1155/2021/8383875 [doi]
LID - 8383875
AB  - The effect of neutrophil gelatinase-associated lipocalin (NGAL) on fetal 
      hemoglobin (HbF) levels in diabetic patients is rarely investigated. This study 
      is aimed at investigating the possible association between NGAL and HbF levels in 
      type 2 diabetes mellitus (T2DM). A total of 160 patients with T2DM and 61 healthy 
      individuals were evaluated. NGAL, HbF, tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-5 (IL-5), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), 
      and urine albumin levels were measured. HbF levels were significantly higher in 
      patients with elevated NGAL than in those without elevated NGAL (1.44% versus 
      0.94%, P = 0.001). High HbF was 2.3 times more prevalent in patients with 
      elevated NGAL than in those without elevated NGAL. In addition, NGAL, TNF-alpha, and 
      IL-5 levels were significantly higher in patients with high HbF than in those 
      with low HbF; however, there was no significant difference in HbA1c and FPG 
      levels between the two groups. HbF was positively correlated with NGAL (r = 
      0.275, P < 0.001), TNF-alpha (r = 0.256, P < 0.001), and IL-5 (r = 0.212, P < 0.001), 
      but not with HbA1c and FPG. An elevated NGAL level led to a 1.27-fold increase in 
      the prevalence of high HbF (odds ratio: 1.27, 95% CI: 1.03-2.51, and P < 0.001). 
      The diagnostic efficacy of NGAL to identify an elevated HbF level was superior to 
      that of HbA1c (area under the curve: 0.697, 95% CI: 0.609-0.786 versus 0.584, 95% 
      CI: 0.488-0.681, and P = 0.022). In conclusion, enhanced NGAL production may be 
      closely linked to elevated HbF in conjunction with proinflammatory cytokines in 
      patients with T2DM.
CI  - Copyright (c) 2021 Jong Weon Choi et al.
FAU - Choi, Jong Weon
AU  - Choi JW
AUID- ORCID: 0000-0002-3775-6237
AD  - Department of Laboratory Medicine, College of Medicine, Inha University, Incheon, 
      Republic of Korea.
FAU - Lee, Moon Hee
AU  - Lee MH
AUID- ORCID: 0000-0002-5965-1815
AD  - Department of Internal Medicine, College of Medicine, Inha University, Incheon, 
      Republic of Korea.
FAU - Fujii, Tatsuyoshi
AU  - Fujii T
AUID- ORCID: 0000-0001-9747-1682
AD  - Department of Internal Medicine, Tsukuba University Hospital Mito Clinical 
      Education and Training Center, Mito Kyodo General Hospital, Ibaraki, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20211020
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9034-63-3 (Fetal Hemoglobin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria/epidemiology
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Cytokines/blood
MH  - Diabetes Mellitus, Type 2/blood/*metabolism
MH  - Diabetic Nephropathies/diagnosis
MH  - Female
MH  - Fetal Hemoglobin/*analysis
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Japan
MH  - Lipocalin-2/*analysis/metabolism
MH  - Lipocalins/urine
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC8550827
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/11/02 06:00
MHDA- 2022/01/27 06:00
PMCR- 2021/10/20
CRDT- 2021/11/01 09:27
PHST- 2021/05/20 00:00 [received]
PHST- 2021/10/05 00:00 [revised]
PHST- 2021/10/07 00:00 [accepted]
PHST- 2021/11/01 09:27 [entrez]
PHST- 2021/11/02 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/10/20 00:00 [pmc-release]
AID - 10.1155/2021/8383875 [doi]
PST - epublish
SO  - Biomed Res Int. 2021 Oct 20;2021:8383875. doi: 10.1155/2021/8383875. eCollection 
      2021.