PMID- 34724560
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20240226
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 41
IP  - 12
DP  - 2021 Dec 22
TI  - In vivo therapeutic exploring for Mori folium extract against type 2 diabetes 
      mellitus in rats.
LID - 10.1042/BSR20210977 [doi]
LID - BSR20210977
AB  - BACKGROUND: The study was aimed to investigate the potential therapeutic effect 
      of Mori folium aqueous extracts (MFAE) on type 2 diabetes mellitus (T2DM) in 
      vivo. METHODS AND RESULTS: A rat model of T2DM was established with the 
      combination of high sugar and high-fat diet (HSFD) and streptozotocin (STZ). The 
      T2DM rats were administrated with low (2 g.kg-1) and high (5 g.kg-1) doses of 
      MFAE for 60 consecutive days. The biochemical indices of glucose metabolism 
      disorders, insulin resistance and oxidative stress were observed. The results 
      indicated that MFAE significantly promoted the synthesis of hepatic glycogen, 
      reduced the levels of fasting blood glucose and fasting blood insulin, and 
      improved the insulin sensitivity index (ISI). MFAE administration also remarkably 
      increased the levels of superoxide dismutase (SOD) and reduced the levels of 
      malondialdehyde (MDA). CONCLUSION: MFAE showed a therapeutic effect on T2DM with 
      the bioative effect of improve glucose metabolism disorders, decrease insulin 
      resistance, and ameliorate the antioxidative ability.
CI  - (c) 2021 The Author(s).
FAU - Lyu, Kaibo
AU  - Lyu K
AD  - College of Environmental and Biological Engineering, Wuhan Technology and 
      Business University, Wuhan 430065, Hubei, P.R. China.
FAU - Yue, Wei
AU  - Yue W
AD  - College of Environmental and Biological Engineering, Wuhan Technology and 
      Business University, Wuhan 430065, Hubei, P.R. China.
FAU - Ran, Junhua
AU  - Ran J
AD  - Department of Nutrition, The First Affiliated Hospital of Xinxiang Medical 
      University, Weihui 453100, Henan, P.R. China.
FAU - Liu, Yunjuan
AU  - Liu Y
AD  - I Faithfood Technology (Beijing) Co., Ltd, Beijing 100007, P.R. China.
FAU - Zhu, Xueliang
AU  - Zhu X
AUID- ORCID: 0000-0003-2148-3905
AD  - State Key Laboratory of Advanced Technology for Materials Synthesis and 
      Processing, Wuhan University of Technology, Wuhan, Hubei 430070, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Plant Extracts)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Blood Glucose/*drug effects/metabolism
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy/pathology
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - Hypoglycemic Agents/isolation & purification/*pharmacology
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Male
MH  - Malondialdehyde/blood
MH  - *Morus/chemistry
MH  - Oxidative Stress/drug effects
MH  - Pancreas/*drug effects/metabolism/pathology
MH  - Plant Extracts/isolation & purification/*pharmacology
MH  - Plant Leaves
MH  - Rats, Sprague-Dawley
MH  - Superoxide Dismutase/blood
MH  - Rats
PMC - PMC8661501
OTO - NOTNLM
OT  - Mori folium aqueous extract
OT  - glucose metabolism
OT  - insulin resistance
OT  - oxidative stress
OT  - type 2 diabetes mellitus
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2021/11/02 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/12/08
CRDT- 2021/11/01 17:23
PHST- 2021/05/14 00:00 [received]
PHST- 2021/09/24 00:00 [revised]
PHST- 2021/10/18 00:00 [accepted]
PHST- 2021/11/02 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/11/01 17:23 [entrez]
PHST- 2021/12/08 00:00 [pmc-release]
AID - 230145 [pii]
AID - BSR20210977 [pii]
AID - 10.1042/BSR20210977 [doi]
PST - ppublish
SO  - Biosci Rep. 2021 Dec 22;41(12):BSR20210977. doi: 10.1042/BSR20210977.