PMID- 34725694
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20240405
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 74
IP  - Suppl_1
DP  - 2022 Jan 20
TI  - Sex Differences in Long-term Outcomes After Group B Streptococcal Infections 
      During Infancy in Denmark and the Netherlands: National Cohort Studies of 
      Neurodevelopmental Impairments and Mortality.
PG  - S54-S63
LID - 10.1093/cid/ciab822 [doi]
AB  - BACKGROUND: Male infants have a higher incidence of invasive group B 
      Streptococcus disease (iGBS) compared with female infants; however, data on sex 
      differences in mortality and long-term outcomes after iGBS are lacking. We 
      assessed whether a child's sex influences the effects of iGBS on mortality and 
      risk of neurodevelopmental impairments (NDIs). METHODS: We used Danish and Dutch 
      registry data to conduct a nationwide cohort study of infants with a history of 
      iGBS. A comparison cohort, children without a history of iGBS, was randomly 
      selected and matched on relevant factors. Effect modification by sex was assessed 
      on additive and multiplicative scales. RESULTS: Our analyses included data from 
      children with a history of iGBS in Denmark (period 1997 -2017; n = 1432) and the 
      Netherlands (2000 -2017; n = 697) and from 21 172 children without iGBS. There 
      was no clear evidence of between-sex heterogeneity in iGBS-associated mortality. 
      Boys had a higher risk of NDI, with evidence for effect modification on additive 
      scale at the age of 5 years for any NDI (relative excess risk due to interaction 
      = 1.28; 95% confidence interval [CI], -0.53 to 3.09 in Denmark and 1.14; 95% CI, 
      -5.13 to 7.41 in the Netherlands). A similar pattern was observed for 
      moderate/severe NDI at age 5 years in Denmark and age 10 years in the 
      Netherlands. CONCLUSION: Boys are at higher risk of NDI ; our results suggest 
      this is disproportionally increased in those who develop iGBS. Future studies 
      should investigate mechanisms of this effect modification by sex.
CI  - (c) The Author(s) 2021. Published by Oxford University Press for the Infectious 
      Diseases Society of America.
FAU - van Kassel, Merel N
AU  - van Kassel MN
AD  - Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, University of 
      Amsterdam, Amsterdam, The Netherlands.
FAU - Goncalves, Bronner P
AU  - Goncalves BP
AD  - Department of Infectious Disease Epidemiology, London School of Hygiene & 
      Tropical Medicine, London, United Kingdom.
AD  - Maternal, Adolescent, Reproductive & Child Health Centre, London School of 
      Hygiene & Tropical Medicine, London, United Kingdom.
FAU - Snoek, Linde
AU  - Snoek L
AD  - Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, University of 
      Amsterdam, Amsterdam, The Netherlands.
FAU - Sorensen, Henrik T
AU  - Sorensen HT
AD  - Department of Clinical Epidemiology, Aarhus University, Aarhus N, Denmark.
FAU - Bijlsma, Merijn W
AU  - Bijlsma MW
AD  - Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, University of 
      Amsterdam, Amsterdam, The Netherlands.
AD  - Department of Paediatrics, Amsterdam UMC, University of Amsterdam, Amsterdam, The 
      Netherlands.
FAU - Lawn, Joy E
AU  - Lawn JE
AD  - Department of Infectious Disease Epidemiology, London School of Hygiene & 
      Tropical Medicine, London, United Kingdom.
AD  - Maternal, Adolescent, Reproductive & Child Health Centre, London School of 
      Hygiene & Tropical Medicine, London, United Kingdom.
FAU - Horvath-Puho, Erzsebet
AU  - Horvath-Puho E
AD  - Department of Clinical Epidemiology, Aarhus University, Aarhus N, Denmark.
CN  - GBS Danish and Dutch Collaborative Group for Long-Term Outcomes
LA  - eng
GR  - OPP1180644/Bill and Melinda Gates Foundation to the London School of Hygiene 
      & Tropical Medicine/
GR  - AGR-2019-731-6962)/LSHTM to the Department of Clinical Epidemiology, Aarhus 
      University Hospital/
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Denmark/epidemiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Male
MH  - Netherlands/epidemiology
MH  - Risk Factors
MH  - *Sex Characteristics
MH  - *Streptococcal Infections/epidemiology
PMC - PMC8775649
OTO - NOTNLM
OT  - Streptococcus agalactiae
OT  - effect modification
OT  - group B Streptococcus
OT  - neurodevelopmental impairments
OT  - sex differences
FIR - Sorensen, Henrik T
IR  - Sorensen HT
FIR - Horvath-Puho, Erzsebet
IR  - Horvath-Puho E
FIR - Sogaard, Kirstine K
IR  - Sogaard KK
FIR - van de Beek, Diederik
IR  - van de Beek D
FIR - Bijlsma, Merijn W
IR  - Bijlsma MW
FIR - van Kassel, Merel N
IR  - van Kassel MN
FIR - Snoek, Linde
IR  - Snoek L
FIR - de Gier, Brechje
IR  - de Gier B
FIR - van der Ende, Arie
IR  - van der Ende A
FIR - Hahne, Susan J M
IR  - Hahne SJM
EDAT- 2021/11/03 06:00
MHDA- 2022/03/16 06:00
PMCR- 2021/11/02
CRDT- 2021/11/02 06:20
PHST- 2021/11/03 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PHST- 2021/11/02 06:20 [entrez]
PHST- 2021/11/02 00:00 [pmc-release]
AID - 6415223 [pii]
AID - ciab822 [pii]
AID - 10.1093/cid/ciab822 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2022 Jan 20;74(Suppl_1):S54-S63. doi: 10.1093/cid/ciab822.