PMID- 34725862
OWN - NLM
STAT- MEDLINE
DCOM- 20220121
LR  - 20220121
IS  - 1520-636X (Electronic)
IS  - 0899-0042 (Linking)
VI  - 34
IP  - 1
DP  - 2022 Jan
TI  - Optically active porous hybrid particles constructed by alkynylated cellulose 
      nanocrystals, helical substituted polyacetylene, and inorganic silica for 
      enantio-differentiating towards naproxen.
PG  - 48-60
LID - 10.1002/chir.23382 [doi]
AB  - This article reports on a novel type of ternary chiral porous hybrid particles 
      (TCPHPs) constructed by alkynylated cellulose nanocrystals (A-CNCs), helical 
      substituted polyacetylene, and inorganic silica. The resulting TCPHPs combine the 
      respective advantages of the three components. A-CNCs serve as stabilizer, 
      co-monomer, and chiral source simultaneously and transfer their chirality to the 
      resulting helical substituted polyacetylenes in the course of copolymerization 
      with achiral acetylenic monomer following "sergeants and soldiers rule". Helical 
      substituted polyacetylenes form chiral helical structures and thus endow TCPHPs 
      with the anticipated optical activity. Inorganic silica constitutes the rigid 
      framework and is covalently bonded with the organic components through hydrolysis 
      of Si-O-Et groups. Phase separation between the organic and inorganic components 
      renders TCPHPs with abundant pores. Scanning electron microscope (SEM) images 
      confirm the formation of spherical particles with porous structures. Circular 
      dichroism spectra demonstrate the optical activity of the chiral hybrid 
      particles. The as-prepared TCPHPs exhibit capacity for enantio-differentiating 
      performance towards chiral naproxen.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Zhong, Hai
AU  - Zhong H
AD  - State Key Laboratory of Chemical Resource Engineering and College of Materials 
      Science and Engineering, Beijing University of Chemical Technology, Beijing, 
      China.
FAU - Zhang, Yingjie
AU  - Zhang Y
AD  - State Key Laboratory of Chemical Resource Engineering and College of Materials 
      Science and Engineering, Beijing University of Chemical Technology, Beijing, 
      China.
FAU - Deng, Jianping
AU  - Deng J
AUID- ORCID: 0000-0002-1442-5881
AD  - State Key Laboratory of Chemical Resource Engineering and College of Materials 
      Science and Engineering, Beijing University of Chemical Technology, Beijing, 
      China.
LA  - eng
GR  - 2019JZZY020218/Major Scientific and Technological Innovation Project in Shandong 
      Province/
GR  - XK1802-2/Fundamental Research Funds for the Central Universities/
GR  - 21774009/National Natural Science Foundation of China/
GR  - 51973011/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211101
PL  - United States
TA  - Chirality
JT  - Chirality
JID - 8914261
RN  - 0 (Polyacetylene Polymer)
RN  - 57Y76R9ATQ (Naproxen)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 9004-34-6 (Cellulose)
SB  - IM
MH  - Cellulose
MH  - *Nanoparticles
MH  - Naproxen
MH  - Polyacetylene Polymer
MH  - Porosity
MH  - *Silicon Dioxide
MH  - Stereoisomerism
OTO - NOTNLM
OT  - chiral
OT  - enantioselective release
OT  - polyacetylene
OT  - porous hybrid particles
EDAT- 2021/11/03 06:00
MHDA- 2022/01/22 06:00
CRDT- 2021/11/02 06:32
PHST- 2021/09/29 00:00 [revised]
PHST- 2021/08/30 00:00 [received]
PHST- 2021/10/15 00:00 [accepted]
PHST- 2021/11/03 06:00 [pubmed]
PHST- 2022/01/22 06:00 [medline]
PHST- 2021/11/02 06:32 [entrez]
AID - 10.1002/chir.23382 [doi]
PST - ppublish
SO  - Chirality. 2022 Jan;34(1):48-60. doi: 10.1002/chir.23382. Epub 2021 Nov 1.