PMID- 34726292
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20221005
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Print)
IS  - 0902-0063 (Linking)
VI  - 36
IP  - 2
DP  - 2022 Feb
TI  - The relationship between COVID-19 and HLA in kidney transplant recipients, an 
      evaluation of predictive and prognostic factors.
PG  - e14525
LID - 10.1111/ctr.14525 [doi]
LID - e14525
AB  - INTRODUCTION: The purpose of this study was to determine the predictive and 
      prognostic factors for COVID-19 infection and its relationship with human 
      leukocyte antigen (HLA) in kidney transplant recipients. MATERIAL AND METHOD: 
      Three hundred fifty kidney transplant recipients were included in the study. 
      Recipients were divided into two groups: COVID-19(+) (n = 100) and control 
      (n = 250). The relationships between HLA frequencies, COVID-19 infection, and 
      prognostic factors (age, donor type, immunosuppression protocol, etc.) were then 
      evaluated. Logistic regression analysis, heatmap, and decision tree methods were 
      used to determine predictive and prognostic factors. The study was performed 
      retrospectively. RESULTS: Advanced age and deceased transplantation emerged as 
      predictive of SARS-CoV-2 infection, while the presence of HLA-A*11, the HLA match 
      ratio, and high-dose tacrolimus were identified as prognostic factors in kidney 
      transplant recipients. HLA-A10, HLA-B*13, HLA-B22, and HLA-B*55 were shown to be 
      associated with SARS-CoV-2 infection at univariate analysis, and HLA-B*57, 
      HLA-DRB1*11, and HLA-DRB1*13 at logistic regression analysis. CONCLUSION: 
      HLA-A10, HLA-B*13, HLA-B*55, HLA-B*57, HLA-DRB1*11, and HLA-DRB1*13 were 
      identified for the first time in the literature associated with SARS-CoV-2 
      infection in kidney transplant recipients.
CI  - (c) 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Ertosun, Mustafa Gokhan
AU  - Ertosun MG
AUID- ORCID: 0000-0002-2557-7346
AD  - Department of Plastic, Reconstructive, and Aesthetic Surgery, Akdeniz University 
      School of Medicine, Antalya, Turkey.
AD  - Tissue Typing and Transplantation Laboratory, Akdeniz University Hospital, 
      Antalya, Turkey.
FAU - Ozkan, Ozlenen
AU  - Ozkan O
AD  - Department of Plastic, Reconstructive, and Aesthetic Surgery, Akdeniz University 
      School of Medicine, Antalya, Turkey.
FAU - Darbas, Sule
AU  - Darbas S
AD  - Tissue Typing and Transplantation Laboratory, Akdeniz University Hospital, 
      Antalya, Turkey.
FAU - Ozel, Deniz
AU  - Ozel D
AD  - Statistical Consulting, Application and Research Center, Akdeniz University, 
      Antalya, Turkey.
FAU - Bilge, Ugur
AU  - Bilge U
AD  - Department of Biostatistics and Medical Informatics, Faculty of Medicine, Akdeniz 
      University, Antalya, Turkey.
FAU - Sayin Ekinci, Nurten
AU  - Sayin Ekinci N
AD  - Tissue Typing and Transplantation Laboratory, Akdeniz University Hospital, 
      Antalya, Turkey.
FAU - Yilmaz, Vural Taner
AU  - Yilmaz VT
AUID- ORCID: 0000-0002-1313-8856
AD  - Department of Internal Medicine Division of Nephrology, Akdeniz University School 
      of Medicine, Antalya, Turkey.
FAU - Ucar, Fahri
AU  - Ucar F
AD  - Tissue Typing and Transplantation Laboratory, Akdeniz University Hospital, 
      Antalya, Turkey.
AD  - Department of Medical Biology and Genetics, Akdeniz University School of 
      Medicine, Antalya, Turkey.
FAU - Kocak, Huseyin
AU  - Kocak H
AD  - Department of Internal Medicine Division of Nephrology, Akdeniz University School 
      of Medicine, Antalya, Turkey.
FAU - Ozkan, Omer
AU  - Ozkan O
AUID- ORCID: 0000-0002-9031-5596
AD  - Department of Plastic, Reconstructive, and Aesthetic Surgery, Akdeniz University 
      School of Medicine, Antalya, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211124
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *COVID-19
MH  - HLA Antigens
MH  - Humans
MH  - *Kidney Transplantation/adverse effects
MH  - Prognosis
MH  - Retrospective Studies
MH  - SARS-CoV-2
MH  - Transplant Recipients
PMC - PMC8646315
OTO - NOTNLM
OT  - SARS-CoV-2
OT  - human leukocyte antigen
OT  - renal transplantation
COIS- None.
EDAT- 2021/11/03 06:00
MHDA- 2022/02/08 06:00
PMCR- 2021/11/24
CRDT- 2021/11/02 09:19
PHST- 2021/10/14 00:00 [revised]
PHST- 2021/06/09 00:00 [received]
PHST- 2021/10/25 00:00 [accepted]
PHST- 2021/11/03 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
PHST- 2021/11/02 09:19 [entrez]
PHST- 2021/11/24 00:00 [pmc-release]
AID - CTR14525 [pii]
AID - 10.1111/ctr.14525 [doi]
PST - ppublish
SO  - Clin Transplant. 2022 Feb;36(2):e14525. doi: 10.1111/ctr.14525. Epub 2021 Nov 24.