PMID- 34726381
OWN - NLM
STAT- MEDLINE
DCOM- 20220209
LR  - 20220209
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 13
IP  - 45
DP  - 2021 Nov 17
TI  - Supramolecular Drug Delivery System from Macrocycle-Based Self-Assembled 
      Amphiphiles for Effective Tumor Therapy.
PG  - 53564-53573
LID - 10.1021/acsami.1c14385 [doi]
AB  - Intelligent drug delivery systems (DDSs) that can improve therapeutic outcomes of 
      antitumor agents and decrease their side effects are urgently needed to satisfy 
      special requirements of treatment of malignant tumors in clinics. Here, the 
      fabrication of supramolecular self-assembled amphiphiles based on the host-guest 
      recognition between a cationic water-soluble pillar[6]arene (WP6A) host and a 
      sodium decanesulfonate guest (G) is reported. The chemotherapeutic agent 
      doxorubicin hydrochloride (DOX) can be encapsulated into the formed vesicle 
      (G/WP6A) to construct supramolecular DDS (DOX@G/WP6A). WP6A affords strong 
      affinities to G to avoid undesirable off-target leakage during delivery. 
      Nanoscaled DOX@G/WP6A is capable of preferentially accumulating in tumor tissue 
      via enhanced permeability and retention (EPR) effect. After internalization by 
      tumor cells, the abundant adenosine triphosphate (ATP) binds competitively with 
      WP6A to trigger the disintegration of self-assembled vesicles with the ensuing 
      release of DOX. In vitro and in vivo research confirmed that DOX@G/WP6A is not 
      only able to promote antitumor efficacy but also reduce DOX-related systemic 
      toxicity. The above favorable findings are ascribed to the formation of ternary 
      self-assembly, which profits from the combination of the factors of the EPR 
      effect and the ATP-triggered release.
FAU - Chen, Junyi
AU  - Chen J
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
AD  - Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry, 
      Ministry of Education, Tianjin Key Laboratory of Structure and Performance for 
      Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 
      300387, P. R. China.
FAU - Zhang, Yadan
AU  - Zhang Y
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
FAU - Zhao, Liang
AU  - Zhao L
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
FAU - Zhang, Yahan
AU  - Zhang Y
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
FAU - Chen, Longming
AU  - Chen L
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
FAU - Ma, Mengke
AU  - Ma M
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
FAU - Du, Xinbei
AU  - Du X
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
FAU - Meng, Zhao
AU  - Meng Z
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
FAU - Li, Chunju
AU  - Li C
AUID- ORCID: 0000-0001-7450-4867
AD  - Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry, 
      Ministry of Education, Tianjin Key Laboratory of Structure and Performance for 
      Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 
      300387, P. R. China.
FAU - Meng, Qingbin
AU  - Meng Q
AUID- ORCID: 0000-0001-8915-9509
AD  - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute 
      of Pharmacology and Toxicology, Beijing 100850, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20211102
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Macrocyclic Compounds)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0 (Surface-Active Agents)
RN  - 0 (pillar(6)arene)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antibiotics, Antineoplastic/chemistry/*pharmacology
MH  - Cell Line
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Doxorubicin/chemistry/*pharmacology
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Drug Screening Assays, Antitumor
MH  - Humans
MH  - Liver Neoplasms, Experimental/drug therapy/pathology
MH  - Macrocyclic Compounds/chemistry/*pharmacology
MH  - Macromolecular Substances/chemistry/pharmacology
MH  - Mice
MH  - Mice, Nude
MH  - Molecular Structure
MH  - Quaternary Ammonium Compounds/chemistry/*pharmacology
MH  - Surface-Active Agents/chemical synthesis/chemistry/*pharmacology
OTO - NOTNLM
OT  - chemotherapy
OT  - competitive release
OT  - drug delivery system
OT  - host-guest recognition
OT  - self-assembled amphiphile
EDAT- 2021/11/03 06:00
MHDA- 2022/02/10 06:00
CRDT- 2021/11/02 12:10
PHST- 2021/11/03 06:00 [pubmed]
PHST- 2022/02/10 06:00 [medline]
PHST- 2021/11/02 12:10 [entrez]
AID - 10.1021/acsami.1c14385 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2021 Nov 17;13(45):53564-53573. doi: 
      10.1021/acsami.1c14385. Epub 2021 Nov 2.