PMID- 34728143
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 42
IP  - 12
DP  - 2021 Dec
TI  - Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in 
      cancer immunotherapy.
PG  - 1113-1127
LID - S1471-4906(21)00209-X [pii]
LID - 10.1016/j.it.2021.10.004 [doi]
AB  - Dendritic cells (DCs) are key immune sentinels that orchestrate protective immune 
      responses against pathogens or cancers. DCs have evolved into multiple 
      phenotypically, anatomically, and functionally distinct cell types. One of these 
      DC types, Type 1 conventional DCs (cDC1s), are uniquely equipped to promote 
      cytotoxic CD8(+) T cell differentiation and, therefore, represent a promising 
      target for harnessing antitumor immunity. Indeed, recent studies have highlighted 
      the importance of cDC1s in tumor immunotherapy using immune checkpoint 
      inhibitors. Here, we review the progress in defining the key developmental and 
      functional attributes of cDC1s and the approaches to optimizing the potency of 
      cDC1s for anticancer immunity.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Zhang, Shengbo
AU  - Zhang S
AD  - The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 
      Parkville, VIC 3052, Australia; Department of Medical Biology, University of 
      Melbourne, Parkville, VIC 3010, Australia.
FAU - Chopin, Michael
AU  - Chopin M
AD  - The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 
      Parkville, VIC 3052, Australia; Department of Medical Biology, University of 
      Melbourne, Parkville, VIC 3010, Australia. Electronic address: 
      chopin@wehi.edu.au.
FAU - Nutt, Stephen L
AU  - Nutt SL
AD  - The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 
      Parkville, VIC 3052, Australia; Department of Medical Biology, University of 
      Melbourne, Parkville, VIC 3010, Australia. Electronic address: nutt@wehi.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211030
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - *Dendritic Cells
MH  - Humans
MH  - Immunotherapy
MH  - Lymphocyte Activation
MH  - *Neoplasms
OTO - NOTNLM
OT  - antigen presentation
OT  - cytokines
OT  - myelopoiesis
OT  - transcription
OT  - tumor immunity
COIS- Declaration of interests The authors declare that they have no competing 
      interests
EDAT- 2021/11/04 06:00
MHDA- 2022/04/08 06:00
CRDT- 2021/11/03 05:50
PHST- 2021/07/29 00:00 [received]
PHST- 2021/10/07 00:00 [revised]
PHST- 2021/10/08 00:00 [accepted]
PHST- 2021/11/04 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2021/11/03 05:50 [entrez]
AID - S1471-4906(21)00209-X [pii]
AID - 10.1016/j.it.2021.10.004 [doi]
PST - ppublish
SO  - Trends Immunol. 2021 Dec;42(12):1113-1127. doi: 10.1016/j.it.2021.10.004. Epub 
      2021 Oct 30.