PMID- 34728160
OWN - NLM
STAT- MEDLINE
DCOM- 20221025
LR  - 20221025
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Linking)
VI  - 55
IP  - 5
DP  - 2022 Oct
TI  - Longitudinal changes in body mass index Z-scores during infancy and risk of 
      childhood allergies.
PG  - 956-964
LID - S1684-1182(21)00228-0 [pii]
LID - 10.1016/j.jmii.2021.10.001 [doi]
AB  - BACKGROUND: Few studies address the dynamic changes of body mass index (BMI) 
      Z-scores during infancy with breastfeeding and their impact on childhood atopic 
      diseases. METHODS: A total of 183 children from a birth cohort regularly 
      followed-up for 4 years were enrolled in this study. Time series data of BMI 
      Z-scores from 1 month to 2 years of age was clustered using K-means method in R 
      software. Breastfeeding status during the first 6 months of life was recorded and 
      classified. The total serum and specific immunoglobulin E (IgE) levels to food 
      and inhalant allergens were measured at age 0.5, 1, 1.5, and 2 years. RESULTS: 
      Using K-means clustering, the dynamic changes in BMI Z-scores were classified 
      into three clusters (cluster A, increasing, n = 62; cluster B; decreasing, 
      n = 62; cluster C, constant low, n = 59). Despite having no statistical 
      association with atopic diseases, a decreasing trend in infantile BMI Z-scores 
      was significantly associated with a higher prevalence of IgE sensitization at age 
      1 which increased the risk of rhinitis development at age 4 (P = 0.007). No 
      difference in BMI Z-scores was determined between different breastfeeding 
      patterns. However, exclusive formula feeding >/=6 months was found to be 
      significantly associated with mite sensitization at age 1.5 years which risks 
      asthma development at age 4 (P = 0.001). CONCLUSIONS: A decreasing trend of BMI 
      Z-scores during infancy is determined to be inversely associated with IgE and 
      allergen sensitization, which may potentially increase the risk of allergies in 
      early childhood.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Sung, Wei-Hsuan
AU  - Sung WH
AD  - School of Traditional Chinese Medicine, Chang Gung University College of 
      Medicine, Taoyuan, Taiwan.
FAU - Yeh, Kuo-Wei
AU  - Yeh KW
AD  - Department of Pediatrics, New Taipei Municipal TuCheng Hospital, Chang Gung 
      Memorial Hospital and Chang Gung University, Taiwan; Community Medicine Research 
      Centre, Chang Gung Memorial Hospital, Keelung, Taiwan.
FAU - Huang, Jing-Long
AU  - Huang JL
AD  - Department of Pediatrics, New Taipei Municipal TuCheng Hospital, Chang Gung 
      Memorial Hospital and Chang Gung University, Taiwan; Community Medicine Research 
      Centre, Chang Gung Memorial Hospital, Keelung, Taiwan.
FAU - Su, Kuan-Wen
AU  - Su KW
AD  - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, 
      Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, and 
      Chang Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Chen, Kuan-Fu
AU  - Chen KF
AD  - Department of Emergency Medicine, Chang Gung Memorial Hospital, and Clinical 
      Informatics and Medical Statistics Research Center, Chang Gung University, 
      Taoyuan, Taiwan.
FAU - Wu, Chin-Chieh
AU  - Wu CC
AD  - Department of Emergency Medicine, Chang Gung Memorial Hospital, and Clinical 
      Informatics and Medical Statistics Research Center, Chang Gung University, 
      Taoyuan, Taiwan.
FAU - Tsai, Ming-Han
AU  - Tsai MH
AD  - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, 
      Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, and 
      Chang Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Hua, Man-Chin
AU  - Hua MC
AD  - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, 
      Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, and 
      Chang Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Liao, Sui-Ling
AU  - Liao SL
AD  - Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, 
      Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, and 
      Chang Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Lai, Shen-Hao
AU  - Lai SH
AD  - Division of Pediatric Pulmonology, Chang Gung Memorial Hospital at Linkou, 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chiu, Chih-Yung
AU  - Chiu CY
AD  - Division of Pediatric Pulmonology, Chang Gung Memorial Hospital at Linkou, 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: 
      pedchestic@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20211025
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Allergens)
SB  - IM
MH  - Child
MH  - Female
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Body Mass Index
MH  - *Hypersensitivity/epidemiology
MH  - Immunoglobulin E
MH  - Allergens
MH  - *Asthma/epidemiology
OTO - NOTNLM
OT  - Allergic sensitization
OT  - Asthma
OT  - BMI Z-scores
OT  - Breastfeeding
OT  - IgE
EDAT- 2021/11/04 06:00
MHDA- 2022/10/26 06:00
CRDT- 2021/11/03 05:51
PHST- 2020/11/17 00:00 [received]
PHST- 2021/09/16 00:00 [revised]
PHST- 2021/10/10 00:00 [accepted]
PHST- 2021/11/04 06:00 [pubmed]
PHST- 2022/10/26 06:00 [medline]
PHST- 2021/11/03 05:51 [entrez]
AID - S1684-1182(21)00228-0 [pii]
AID - 10.1016/j.jmii.2021.10.001 [doi]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2022 Oct;55(5):956-964. doi: 
      10.1016/j.jmii.2021.10.001. Epub 2021 Oct 25.